Patents by Inventor Harmon Zuccola

Harmon Zuccola has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
    Patent number: 8712749
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexes with AMP-PNP.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: April 29, 2014
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • CRYSTAL STRUCTURE OF HUMAN JAK3 KINASE DOMAIN COMPLEX AND BINDING POCKETS THEREOF
    Publication number: 20130137125
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexes with AMP-PNP.
    Type: Application
    Filed: May 24, 2012
    Publication date: May 30, 2013
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
    Patent number: 8192972
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: June 5, 2012
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • CRYSTAL STRUCTURE OF HUMAN JAK3 KINASE DOMAIN COMPLEX AND BINDING POCKETS THEREOF
    Publication number: 20110014680
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
    Type: Application
    Filed: May 26, 2009
    Publication date: January 20, 2011
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: HARMON ZUCCOLA, MARC JACOBS, LOVORKA SWENSON, KUMKUM SAXENA
  • Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
    Patent number: 7558717
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
    Type: Grant
    Filed: April 26, 2005
    Date of Patent: July 7, 2009
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • Structure-based approach to design of protein-processivity factor interactions
    Publication number: 20070055459
    Abstract: A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.
    Type: Application
    Filed: November 6, 2006
    Publication date: March 8, 2007
    Inventors: Donald Coen, James Hogle, Carl Elkin, Harmon Zuccola, Kristie Bridges, Scott Lokey
  • Crystal structure of human JAK3 kinase domain complex and binding pockets thereof
    Publication number: 20060030018
    Abstract: The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to JAK3 protein or JAK3 protein homologues, or complexes thereof. The invention also relates to crystallizable compositions and crystals comprising JAK3 kinase domain and JAK3 kinase domain complexed with AMP-PNP.
    Type: Application
    Filed: April 26, 2005
    Publication date: February 9, 2006
    Inventors: Harmon Zuccola, Marc Jacobs, Lovorka Swenson, Kumkum Saxena
  • Oligomerization of hepatitis delta antigen
    Publication number: 20050170337
    Abstract: This invention relates to HDAg peptides, including mutants, derivatives fragments and fusion molecules, including fusion proteins, coiled-coil oligomers, nucleic acid molecules, vectors comprising HDAg nucleic acid molecules, cells comprising said molecules, methods of multivalent expression and association of binding moieties of HDAg fusion molecules, and methods of use involving the molecules. The molecules are particularly useful as a framework for multivalent display via formation of C-terminal and/or N-terminal fusion proteins or via chemical coupling to chemically reactive sidechains, e.g. cysteine residues.
    Type: Application
    Filed: January 18, 2005
    Publication date: August 4, 2005
    Applicant: President and Fellows of Harvard College
    Inventors: James Hogle, Harmon Zuccola, David Filman, Carl Elkin