Patents by Inventor Harold A. Crisp

Harold A. Crisp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing cefuroxime axetil
    Patent number: 5013833
    Abstract: There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.
    Type: Grant
    Filed: October 18, 1988
    Date of Patent: May 7, 1991
    Assignee: Glaxo Group Limited
    Inventors: Harold A. Crisp, John C. Clayton, Leonard G. Elliott, Edward M. Wilson
  • Process for preparation of cefuroxime ester
    Patent number: 4994567
    Abstract: There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.
    Type: Grant
    Filed: October 18, 1988
    Date of Patent: February 19, 1991
    Assignee: Galaxo Group Limited
    Inventors: Harold A. Crisp, John C. Clayton, Edward M. Wilson
  • Preparation of a highly pure, substantially amorphous form of cefuroxime axetil
    Patent number: 4820833
    Abstract: There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.
    Type: Grant
    Filed: December 4, 1986
    Date of Patent: April 11, 1989
    Assignee: Glaxo Group Limited
    Inventors: Harold A. Crisp, John C. Clayton, Leonard G. Elliott, Edward M. Wilson
  • Amorphous form of cefuroxime ester
    Patent number: 4562181
    Abstract: There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.
    Type: Grant
    Filed: July 29, 1983
    Date of Patent: December 31, 1985
    Assignee: Glaxo Group Limited
    Inventors: Harold A. Crisp, John C. Clayton