Abstract: The present invention provides compositions and methods related to determining the severity of viral infections and identifying antiviral agents. In certain embodiments, the invention comprises determining the expression level of APOBEC-1 related proteins, where the expression level of APOBEC-1 related proteins is an indicator for disease severity and/or effectiveness of a potential antiviral agent. In one embodiment, the present invention provides for a method of screening for an antiviral agent.

Abstract: The invention provides a porous nanoscale membrane. In one embodiment, the membrane can be used as a filtration device to screen agents that disrupt or prevent molecular interactions. In one embodiment, the membrane allows for screening agents that disrupt or prevent molecular interactions using a small sample volume with efficient high-throughput screening applications.

Abstract: The present invention provides an assay for screening any agent that modulates the ability of A3G to bind with RNA. The invention provides an agent identified by high throughput screening methods and methods of treatment using the identified agent as a means of inhibiting HIV infection and reducing the emergence of viral drug-resistance.

Abstract: A compound of the formula X1-M-SEQ ID NO:1, or a derivative thereof, is provided, wherein X1-M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of the amino acid sequence SEQ ID NO:1. Pharmaceutical compositions comprising and therapeutic methods using the compound are also provided.

Abstract: The present invention relates to large-scale production of ElonginB, ElonginC, Vif, and Cullin5. The present invention provides an assay for screening any agent that inhibits the ability of Vif to bind with Cul5. The invention provides an agent identified by the screening methods and methods of treatment using the identified agent.

Abstract: This invention relates to cytidine deaminase inhibitors (Cytidine deaminase inhibitors) of cytidine deaminases and uses thereof.

Abstract: The invention provides a porous nanoscale membrane. In one embodiment, the membrane can be used as a filtration device to screen agents that disrupt or prevent molecular interactions. In one embodiment, the membrane allows for screening agents that disrupt or prevent molecular interactions using a small sample volume with efficient high-throughput screening applications.

Abstract: Products and methods for modifying apolipoprotein B mRNA editing in vivo, reducing serum LDL levels, and treating or preventing an atherogenic disease or disorder are disclosed. Such methods involve the use of a protein including APOBEC-1 or fragments thereof which can edit mRNA encoding apolipoprotein B. The protein including APOBEC-1 can be taken up by cells in the form of a delivery vehicle, such as a liposome or niosome, or directly as a chimeric protein which includes a first polypeptide that includes a protein transduction domain and a second polypeptide that includes APOBEC-1 or a fragment thereof which can edit mRNA encoding apolipoprotein B.

Abstract: Disclosed are methods and compositions related to the structure and function of APOBEC3G.

Abstract: Disclosed are compositions for chimeric proteins comprising a protein transduction domain and a deaminase domain, mimetics or analog thereof, and uses of same.

Abstract: Disclosed are methods and compositions related to APOBEC-1.

Abstract: A compound of the formula X1-M-SEQ ID NO:1, or a derivative thereof, is provided, wherein X1-M- represents an optional group comprising a protein transduction domain conjugated to the N-terminus of the amino acid sequence SEQ ID NO:1. Pharmaceutical compositions comprising and therapeutic methods using the compound are also provided.

Abstract: Disclosed are methods and compositions related to determining the status and mechanisms underlying long-term nonprogression of viral infections.

Abstract: This invention relates to cytidine deaminase inhibitors (Cytidine deaminase inhibitors) of cytidine deaminases and uses thereof.

Abstract: Disclosed are methods and compositions related to ACF and to APOBEC-1.

Abstract: Products and methods for modifying apolipoprotein B mRNA editing in vivo, reducing serum LDL levels, and treating or preventing an atherogenic disease or disorder are disclosed. Such methods involve the use of a protein including APOBEC-1 or fragments thereof which can edit mRNA encoding apolipoprotein B. The protein including APOBEC-1 can be taken up by cells in the form of a delivery vehicle, such as a liposome or noisome, or directly as a chimeric protein which includes a first polypeptide that includes a protein transduction domain and a second polypeptide that includes APOBEC-1 or a fragment thereof which can edit mRNA encoding apolipoprotein B.

Abstract: An operable hanger includes a pair of legs connected at their lower ends and generally symmetrically oriented about a vertical central axis. Horizontally oriented tips at the upper ends of the legs will selectively engage a support structure by movement towards one another. A slide bar mounted on the legs is vertically movable to bias the leg tips towards one another when moved downwardly and bias the leg tips away from one another when moved upwardly. A support hook is attached to the slide bar by a chain to support a bird feeder or other object below the hanger.

Abstract: A hanger for removable engagement with a support member includes a rigid body with a hook-shaped upper end and a lower end having a removable support attachment for supporting an article on the hanger.

Abstract: A hanger for removable engagement with a support member includes a rigid body with a hook-shaped upper end and a lower end having a removable support attachment for supporting an article on the hanger.

Abstract: A hanger includes a bracket with forward and rearward panels, and a connecting panel connecting the upper ends of the forward and rearward panels, to support bracket on a lattice. The connecting panel of the bracket has a generally V-shape lower surface which closely fits the upper surface of a strap intersection on the lattice, formed by the upper longitudinal edges of a pair of forward and rearward straps. A support arm mounted on the forward panel includes a horizontal arm projecting forwardly therefrom with a hook for suspending an object from the lattice. In one embodiment of the invention, a rod is mounted on the rearward panel and extends upwardly therefrom to engage a second strap intersection above the strap intersection upon which the bracket is mounted. In a second embodiment of the invention, the bracket is locked in position on the strap intersection by connecting the lower ends of the forward and rearward panels below the strap intersection.