Patents by Inventor Harold Coates
Harold Coates has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10100733Abstract: An anti-ice valve, a turbine engine including an anti-ice valve assembly and a method of operating an anti-ice valve where an anti-ice valve has a housing and a valve element configured to control a flow of hot bleed air through the housing, and a muscle air passage extending through the housing, a cooling air passage extending through the housing, and a heat exchanger located within the housing and having heat transfer surfaces in thermal communication with the muscle air passage and the cooling air passage.Type: GrantFiled: July 31, 2015Date of Patent: October 16, 2018Assignee: GE Aviation Systems LLCInventors: Michael Timothy O'Toole, Kevin Harold Coates, Michael Robert Wackett
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Publication number: 20170030265Abstract: An anti-ice valve, a turbine engine including an anti-ice valve assembly and a method of operating an anti-ice valve where an anti-ice valve has a housing and a valve element configured to control a flow of hot bleed air through the housing, and a muscle air passage extending through the housing, a cooling air passage extending through the housing, and a heat exchanger located within the housing and having heat transfer surfaces in thermal communication with the muscle air passage and the cooling air passage.Type: ApplicationFiled: July 31, 2015Publication date: February 2, 2017Inventors: Michael Timothy O'TOOLE, Kevin Harold COATES, Michael Robert WACKETT
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Patent number: 6569883Abstract: The invention relates to the use of compounds of the general formula (I) wherein R1 represents a hydrogen atom or a C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-(C1-4)alkyl, C3-6 alkenyl, C3-10 alkynyl, phenyl or phenyl-C1-3 alkyl group; and one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6 alkyl, C3-7cycloalkyl, C2-6 alkenyl or phenyl-C1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting and/or the promotion of gastric emptying and for the manufacture of a medicament for this purpose.Type: GrantFiled: May 5, 1999Date of Patent: May 27, 2003Assignee: Glaxo Group LimitedInventors: Michael Brian Tyers, Ian Harold Coates, David Cedric Humber, George Blanch Ewan, James Angus Bell
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Patent number: 6175014Abstract: The invention provides a process for the preparation of a compound of general formula (I): wherein Im represents an imidazolyl group of the formula: and R1 represents a hydrogen atom or a group as herein defined including —CO2R5, —COR5, —CONR5R6 or —SO2R5 wherein R5 and R6, which may be the same or different, are as herein defined with the proviso that R5 does not represent a hydrogen atom when R1 represents a group —CO2R5 or —SO2R5; one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6alkyl, C3-7cycloaklyl, C3-6alkenyl, phenyl or phenyl C1-3alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6alkyl group; and n represents 2 or 3; which comprises reacting a compound of formula (II) or a protected derivative thereof, with a compound of formula (III): HOCH2-Im (III) or a salt thereof in the presence of an acid at an elevatType: GrantFiled: October 18, 1993Date of Patent: January 16, 2001Assignee: Glaxo Group LimitedInventors: Ian Harold Coates, Alexander William Oxford, Peter Charles North, Thomas Miller, Anthony David Baxter, Kevin Ian Hammond
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Patent number: 5922749Abstract: The invention relates to the use of compounds of the general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a C.sub.1-10 alkyl, C.sub.3-7 cycloalkyl, C.sub.3-7 cycloalkyl-(C.sub.1-4) alkyl, C.sub.3-6 alkenyl, C.sub.3-10 alkynyl, phenyl or phenyl-C.sub.1-3 alkyl group; and one of the groups represented byR.sup.2, R.sup.3 and R.sup.4 is a hydrogen atom or a C.sub.1-6 alkyl, C.sub.3-7 cycloalkyl, C.sub.2-6 alkenyl or phenyl-C.sub.1-3 alkyl group and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C.sub.1-6 alkyl group;and physiologically acceptable salts and solvates thereof, for the relief of nausea and vomiting and/or the promotion of gastric emptying and for the manufacture of a medicament for this purpose. Promotion of gastric emptying may be for the relief of gastro-intestinal disorders associated with gastric stasis or may be of advantage in radiological examination procedures.Type: GrantFiled: August 16, 1996Date of Patent: July 13, 1999Assignee: Glaxo Group LimitedInventors: Michael Brian Tyers, Ian Harold Coates, David Cedric Humber, George Blanch Ewan, James Angus Bell
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Patent number: 4096131Abstract: Moisture curable extrudable polysulphide sealants comprise the reaction product of (a) a silanized polysulphide obtained by reacting an SH terminated polysulphide with a silane having 2 or 3 hydrolyzable groups and 1 or 2 groups capable of reacting with the SH group in order to cover up to 30% of the SH groups with the silane and (b) a disulphide containing the group ##STR1## group wherein het is an O or S atom or N-organic group. Other moisture curable extrudable sealants comprise the silanized polysulphide (a) and an ortho ester e.g. triethylorthoacetate.Type: GrantFiled: March 15, 1976Date of Patent: June 20, 1978Assignee: Albright & Wilson LimitedInventors: Norman O. Price, Harold Coates, Christopher S. Ely
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Patent number: 4020090Abstract: Novel organotin compounds exhibit the general formula ##STR1## where R and R.sub.1 are individually selected from the group consisting of C.sub.1 and C.sub.12 alkyl groups, cycloalkyl radicals and phenyl radicals; X is a group of the formula ##STR2## wherein R' is a hydrogen, C.sub.1 to C.sub.20 alkyl, cycloalkyl, or phenyl group;R" is a C.sub.1 to C.sub.20 alkyl, phenyl, hydroxyphenyl, or methoxyphenyl group or the radical CH.sub.2 COOR.sub.5, where R.sub.5 is an alkyl radical of 1 to 8 carbon atoms;R"' is R.sub.6 or is (CH.sub.2).sub.n COOR.sub.6 where R.sub.6 is an alkyl radical of from 1 to 20 carbon atoms, a cycloalkyl or a phenyl radical, m is an integer from 3 to 7 and n is an integer from 1 to 4;R.sub.2 and R.sub.3 are selected from the same group as R;R.sub.4 is selected from the same group as R';Y is selected from the same group of groups as X or exhibits a formula selected from the group consisting of S(CH.sub.2).sub.n COOR.sub.7, OOCCH=CHCOOR.sub.7 and OOCCH=CHCOSCH.sub.2 COOR.sub.Type: GrantFiled: November 19, 1974Date of Patent: April 26, 1977Assignee: Albright & Wilson LimitedInventors: John Desmond Collins, Harold Coates, Iftikhar Hussain Siddiqui
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Patent number: 3978102Abstract: Organotin compounds with low tin content suitable as stabilizers for halogen containing resins e.g. polyvinyl chloride are of formula ##EQU1## where R.sub.1 and R.sub.2 are C.sub.1-20 alkyl, cycloalkyl or phenyl groups, Q.sub.1 represents a radical selected from the group consisting of ##EQU2## Q.sub.2 is a hydrogen atom, an alkyl group containing between 1 and 6 carbon atoms or the group --CH.sub.2 Z.sub.3.Z.sub.1, z.sub.2, and Z.sub.3 are individually selected from the group of groups consisting of ##EQU3## and ##EQU4## R.sub.3 is an alkyl group containing between 1 and 20 carbon atoms, a substituted or unsubstituted phenyl group or a substituted or unsubstituted alkylphenyl group.R.sub.4 is an alkyl grup containing between 1 and 20 carbon atoms, a substituted phenylakly or unsubstituted phenylalkyl group wherein the alkyl portion of the radical contains between 1 and 6 carbon atoms.R.sub.Type: GrantFiled: January 13, 1975Date of Patent: August 31, 1976Assignee: Albright & Wilson LimitedInventors: Harold Coates, John Desmond Collins, Iftikhar Hussain Siddiqui
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Patent number: 3978023Abstract: Halogenated vinyl resins such as poly(vinyl chloride) (P.V.C.) are stabilized against degradation by the addition of stabilizers comprising specified monoorganotin sulfur-containing compounds, for example the reaction product of a mono-organotin tris mercapto carboxylic acid ester and a di-organotin sulfide in combination with an alkyl, aryl or mixed alkyl-aryl ester of phosphorous acid. Preferably the stabilizers also include a hindered phenol.Type: GrantFiled: February 4, 1972Date of Patent: August 31, 1976Assignee: Albright & Wilson LimitedInventors: Harold Coates, Peter Albert Theodore Hoye, Anthony James Wilkins
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Patent number: 3972908Abstract: Organotin compounds of formula ##EQU1## where a is 0 or 1, x, x', y and y' are 1-6, R.sub.1, R.sub.2 R.sub.6 and R.sub.7 are C.sub.1-12 alkyl, cycloalkyl, aromatic or aralkyl hydrocarbyl, R.sub.4 and R.sub.9 are as defined for R.sub.1 or are C.sub.13-21 alkyl, C.sub.2-21 alkenyl or substituted aromatic hydrocarbyl, R.sub.3, R.sub.5, R.sub.8 and R.sub.10 are as defined for R.sub.4 or are hydrogen or a pair of R.sub.3 and R.sub.5 or R.sub.8 together with the carbon atom to which they are joined forms a cycloalkyl ring and X is O or S, are stabilizers for halogen containing resins, especially PVC.Type: GrantFiled: December 5, 1974Date of Patent: August 3, 1976Assignee: Albright & Wilson LimitedInventors: John Desmond Collins, Harold Coates, Iftikhar Hussain Siddiqui
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Patent number: 3962295Abstract: Organothiotin compounds with low tin content suitable as stabilizers for halogen containing resins e.g. polyvinyl chloride, are of formula ##EQU1## wherein R.sub.1 and R.sub. 2 are individually selected from the group consisting of alkyl radicals containing between 1 and 20 carbon atoms, cycloalkyl and phenyl radicals, m is an integer between 1 and 8, inclusive, and X and Y and individually selected from the group of radicals exhibiting the formulae ##EQU2## wherein Q.sub.1 represents a hydrogen atom, an alkyl radical containing between 1 and 6 carbon atoms, inclusive, or the radical CH.sub.2 Z.sub.3, wherein Z.sub.1, Z.sub.2 and Z.sub.3 are individually selected from the group of radicals exhibiting the formulae ##EQU3## and ##EQU4## or X and Y together form a divalent radical selected from the group consisting of ##EQU5## and ##EQU6## Q.sub.2 represents a divalent radical of a formula selected from the group consisting of ##EQU7## and wherein R.sub.Type: GrantFiled: December 17, 1974Date of Patent: June 8, 1976Inventors: John Desmond Collins, Harold Coates, Iftikhar Hussain Siddiqui
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Patent number: 3951956Abstract: The invention relates to a novel process for the preparation of 3-hydroxy penam-1-oxides and esterified and etherified derivatives thereof. The process involves reaction of a penam-1-oxide mixed anhydride with a peracid followed by rearrangement and decarboxylation of the product initially formed to yield a 3-aroyloxy-penam-1-oxide. The latter compound may if desired subsequently be subjected to reductive cleavage to yield a 3-hydroxy compound, such reductive cleavage conveniently being effected by means of zinc and an ammonium salt under neutral or acidic conditions. The compounds prepared by the process of this invention are useful as intermediates in the preparation of antibiotics.Type: GrantFiled: January 16, 1974Date of Patent: April 20, 1976Assignee: Glaxo Laboratories LimitedInventors: Peter George Sammes, Ian Harold Coates
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Patent number: 3933744Abstract: An ester, which is a costabiliser of mono ordi organotin stabilisers for halogen containing resins, is of formula ##EQU1## wherein x and y are 1-6, R.sub.4 and R.sub.9 are alkyl, alkenyl, cycloalkyl or optionally substituted aromatic aralkyl or aralkenyl hydrocarbyl group, R.sub.3 and R.sub.5 are as R.sub.4 or R.sub.9 or is hydrogen or R.sub.3 and R.sub.5 form a cycloalkyl ring. The organotin stabilisers are carboxylates, mercapto carboxylates, carboxylate ester from diacids, sulphides, mercaptides or thiostannoic acids.Type: GrantFiled: June 16, 1975Date of Patent: January 20, 1976Assignee: Albright & Wilson LimitedInventors: Harold Coates, John Desmond Collins, Iftikhar H. Siddiqui
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Patent number: 3933743Abstract: Organotin compounds with low tin content suitable as stabilizers for halogen containing resins e.g. polyvinyl chloride are of formula ##EQU1## where R.sub.1 and R.sub.2 are C.sub.1.sub.-20 alkyl, cycloalkyl or phenyl, Q.sub.1 is of formula --C(CH.sub.2 Z).sub.2 Q.sub.2, wherein Q.sub.2 is H, C.sub.1.sub.-6 alkyl or CH.sub.2 Z, and each Z is ##EQU2## or a pair of Z is ##EQU3## R.sub.3 is C.sub.1.sub.-20 alkyl, optionally substituted phenyl, or alkylphenyl or if two R.sub.3 groups are present in the molecule, they may constitute a single bond between the carbon atoms immediately adjacent to said R.sub.3 radicals, C.sub.1.sub.-20 alkylene C.sub.2.sub.-20 alkenylene or optionally substituted phenylene, R.sub.4 is C.sub.1.sub.-20 alkyl, optionally substituted phenyl (C.sub.1.sub.-6) alkyl or two groups R.sub.4 are optionally phenyl substituted C.sub.1.sub.-20 alkylene or C.sub.2.sub.-20 alkenylene or C.sub.5.sub.-6 cycloalkylene R.sub.5 is C.sub.1.sub.Type: GrantFiled: July 22, 1974Date of Patent: January 20, 1976Assignee: Albright & Wilson LimitedInventors: Harold Coates, John Desmond Collins, Iftikhar Hussain Siddiqui
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Patent number: 3933750Abstract: Organothiotin compounds with low tin content suitable as stabilizers for halogen containing resins e.g. polyvinyl chloride, are of formula R.sub.1 R.sub.2 Sn(X) -- SC.sub.m H.sub.2m S -- (Y)SnR.sub.1 R.sub.2, where R.sub.1 and R.sub.2 are C.sub.1-20 alkyl, cycloalkyl or phenyl, m is 1-8, X and Y are of formula --OCOCH = CHCOOCH.sub.2 Q.sub.1, --S(CH.sub.2).sub.n COOCH.sub.2 Q.sub.1, or --OOC(CH.sub.2).sub.n S -- CH.sub.3 S(CH.sub.2).sub.n COOR.sub.5 SR.sub.4, OCOCH = CHCOOR.sub.5 or S(CH.sub.2).sub.2 COOR.sub.5, where Q.sub.1 is --C(Q.sub.2)(CH.sub.2 Z).sub.2, where Q.sub.2 is H, C.sub.1-6 alkyl or CH.sub.2 Z, Z is OOCR.sub.3 OOC(CH.sub.2).sub.n SR.sub.4, --OOCR.sub.6 COOR.sub.5 or a pair of Z is --OOC(CH.sub.2).sub.a S CHR.sub.3 S(CH.sub.2).sub.n COO--, R.sub.3 is C.sub.1-20 alkyl optionally substituted phenyl or alkylphenyl or if two R.sub.3 groups are present in the molecule, they may constitute a single bond between the carbon atoms immediately adjacent to said R.sub.3 radicals, C.sub.1-20 alkylene, C.Type: GrantFiled: July 22, 1974Date of Patent: January 20, 1976Assignee: Albright & Wilson LimitedInventors: Harold Coates, John Desmond Collins, Iftikhar Hussain Siddiqui