Patents by Inventor Harold D. Doshan

Harold D. Doshan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF (R)-N-METHYLNALTREXONE
    Publication number: 20170143700
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Application
    Filed: February 8, 2017
    Publication date: May 25, 2017
    Applicant: Progenics Pharmaceuticals, Inc.
    Inventors: Harold D. Doshan, Julio Perez
  • Synthesis of (R)-N-methylnaltrexone
    Patent number: 9597327
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: March 21, 2017
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Harold D. Doshan, Julio Perez
  • SYNTHESIS OF (R)-N-METHYLNALTREXONE
    Publication number: 20150290187
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Application
    Filed: June 22, 2015
    Publication date: October 15, 2015
    Inventors: Harold D. Doshan, Julio Perez
  • SYNTHESIS OF (R)-N-METHYLNALTREXONE
    Publication number: 20150057303
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Application
    Filed: March 18, 2014
    Publication date: February 26, 2015
    Applicant: PROGENICS PHARMACEUTICALS, INC.
    Inventors: Harold D. Doshan, Julio Perez
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8853232
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Grant
    Filed: September 4, 2013
    Date of Patent: October 7, 2014
    Assignees: Wyeth LLC, Progenics Pharmaceuticals., Inc.
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20140142132
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Application
    Filed: September 4, 2013
    Publication date: May 22, 2014
    Applicants: WYETH, LLC, PROGENICS PHARMACEUTICALS, INC.
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • Peripheral opioid receptor antagonists and uses thereof
    Patent number: 8546418
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Grant
    Filed: March 28, 2008
    Date of Patent: October 1, 2013
    Assignees: Progenics Pharmaceuticals, Inc., Wyeth, LLC
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • Synthesis of -methylnaltrexone
    Patent number: 8343992
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: January 1, 2013
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Harold D. Doshan, Julio Perez
  • PERIPHERAL OPIOID RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20110190331
    Abstract: The present invention provides a compound of formula I: wherein R1, R2, R2? and X? are as defined and described herein, methods of manufacture thereof and compositions thereof, useful for example as peripheral mu opioid receptor antagonists in treatment of side effects of opioid administration.
    Type: Application
    Filed: March 28, 2008
    Publication date: August 4, 2011
    Inventors: Alfred A. Avey, Appavu Chandrasekaren, Harold D. Doshan, Julio Perez, Yakov Rotshteyn
  • SYNTHESIS OF R-N-METHYLNALTREXONE
    Publication number: 20100311781
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Application
    Filed: January 22, 2010
    Publication date: December 9, 2010
    Inventors: Harold D. Doshan, Julio Perez
  • Synthesis of R-N-methylnaltrexone
    Patent number: 7674904
    Abstract: This invention relates to stereoselective synthesis of R-MNTX and intermediates thereof, pharmaceutical preparations comprising R-MNTX or intermediates thereof and methods for their use.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: March 9, 2010
    Assignee: Progenics Pharmaceuticals, Inc.
    Inventors: Harold D. Doshan, Julio Perez