Patents by Inventor Harold D. Waitz

Harold D. Waitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7943292
    Abstract: Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a host's blood volume is replaced with a blood substitute.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: May 17, 2011
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Patent number: 7503913
    Abstract: Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or transfused with at least two fluid compositions. The first fluid composition is a non-naturally occurring biological buffer free plasma-like solution and the second fluid composition is a fluid blood composition. In a preferred embodiment, an additional volume of the first solution, or a derivative thereof, is administered to the patient following introduction of the fluid blood composition. Also provided are kits and systems for performing the subject methods. The subject methods and compositions find use in variety of perfusion applications, including the treatment of hypothermic surgical applications, cryogenic procedures, and the like.
    Type: Grant
    Filed: October 12, 2005
    Date of Patent: March 17, 2009
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Harold D. Waitz, Hal Sternberg
  • Publication number: 20080220406
    Abstract: Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a host's blood volume is replaced with a blood substitute.
    Type: Application
    Filed: September 6, 2007
    Publication date: September 11, 2008
    Applicant: BIOTIME, INC.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Patent number: 6991624
    Abstract: Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or transfused with at least two fluid compositions. The first fluid composition is a non-naturally occurring biological buffer free plasma-like solution and the second fluid composition is a fluid blood composition. In a preferred embodiment, an additional volume of the first solution, or a derivative thereof, is administered to the patient following introduction of the fluid blood composition. Also provided are kits and systems for performing the subject methods. The subject methods and compositions find use in variety of perfusion applications, including the treatment of hypothermic surgical applications, cryogenic procedures, and the like.
    Type: Grant
    Filed: May 23, 2003
    Date of Patent: January 31, 2006
    Assignee: Biotime, Inc.
    Inventors: Paul E. Segall, Harold D. Waitz, Hal Sternberg
  • Publication number: 20040086578
    Abstract: Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a host's blood volume is replaced with a blood substitute.
    Type: Application
    Filed: October 10, 2003
    Publication date: May 6, 2004
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Publication number: 20040082022
    Abstract: An artificial plasma-like substance having at least one water soluble polysaccharide oncotic agent selected from the group consisting of high molecular weight hydroxyethyl starch, low molecular weight hydroxyethyl starch, dextran 40 and dextran 70, which is buffered by lactate and has a pre-administration pH of between 4 and 6.5 is disclosed. In one embodiment, the artificial plasma-like solution may have at least two water soluble polysaccharide oncotic agents one of which is eliminated from the circulation slowly and the other of which is eliminated from the circulation quickly. Supplementation of the plasma-like solution with certain ions is described. A system for administration of the plasma-like solution to a subject wherein the system comprises a first and second solution each having particular buffers is described. Methods for the administration of the plasma-like solution are also disclosed.
    Type: Application
    Filed: August 13, 2003
    Publication date: April 29, 2004
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Publication number: 20040018966
    Abstract: Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or transfused with at least two fluid compositions. The first fluid composition is a non-naturally occurring biological buffer free plasma-like solution and the second fluid composition is a fluid blood composition. In a preferred embodiment, an additional volume of the first solution, or a derivative thereof, is administered to the patient following introduction of the fluid blood composition. Also provided are kits and systems for performing the subject methods. The subject methods and compositions find use in variety of perfusion applications, including the treatment of hypothermic surgical applications, cryogenic procedures, and the like.
    Type: Application
    Filed: May 23, 2003
    Publication date: January 29, 2004
    Inventors: Paul E. Segall, Harold D. Waitz, Hal Sternberg
  • Patent number: 6680305
    Abstract: Physiologically acceptable aqueous solutions and methods for their use are provided. The subject solutions comprise: electrolytes; a dynamic buffering system and an oncotic agent; and do not comprise a conventional biological buffer. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a host's blood volume is replaced with a blood substitute.
    Type: Grant
    Filed: April 20, 2000
    Date of Patent: January 20, 2004
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Patent number: 6627393
    Abstract: An artificial plasma-like substance having at least one water soluble polysaccharide oncotic agent selected from the group consisting of high molecular weight hydroxyethyl starch, low molecular weight hydroxyethyl starch, dextran 40 and dextran 70, which is buffered by lactate and has a pre-administration pH of between 4 and 6.5 is disclosed. In one embodiment, the artificial plasma-like solution may have at least two water soluble polysaccharide oncotic agents one of which is eliminated from the circulation slowly and the other of which is eliminated from the circulation quickly. Supplementation of the plasma-like solution with certain ions is described. A system for administration of the plasma-like solution to a subject wherein the system comprises a first and second solution each having particular buffers is described. Methods for the administration of the plasma-like solution are also disclosed.
    Type: Grant
    Filed: December 30, 1999
    Date of Patent: September 30, 2003
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Patent number: 6589223
    Abstract: Methods and compositions for use in perfusion applications are provided. In the subject methods, a subject or derivative thereof, e.g. isolated organ or tissue, is infused, perfused and/or transfused with at least two fluid compositions. The first fluid composition is a non-naturally occurring biological buffer free plasma-like solution and the second fluid composition is a fluid blood composition. In a preferred embodiment, an additional volume of the first solution, or a derivative thereof, is administered to the patient following introduction of the fluid blood composition. Also provided are kits and systems for performing the subject methods. The subject methods and compositions find use in variety of perfusion applications, including the treatment of hypothermic surgical applications, cryogenic procedures, and the like.
    Type: Grant
    Filed: February 3, 1999
    Date of Patent: July 8, 2003
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Harold D. Waitz, Hal Sternberg
  • Publication number: 20030022147
    Abstract: An artificial plasma-like substance having at least one water soluble polysaccharide oncotic agent selected from the group consisting of high molecular weight hydroxyethyl starch, low molecular weight hydroxyethyl starch, dextran 40 and dextran 70, which is buffered by lactate and has a pre-administration pH of between 4 and 6.5 is disclosed. In one embodiment, the artificial plasma-like solution may have at least two water soluble polysaccharide oncotic agents one of which is eliminated from the circulation slowly and the other of which is eliminated from the circulation quickly. Supplementation of the plasma-like solution with certain ions is described. A system for administration of the plasma-like solution to a subject wherein the system comprises a first and second solution each having particular buffers is described. Methods for the administration of the plasma-like solution are also disclosed.
    Type: Application
    Filed: December 30, 1999
    Publication date: January 30, 2003
    Inventors: PAUL E. SEGALL, HAL STERNBERG, HAROLD D. WAITZ, JUDITH M. SEGALL
  • Patent number: 6506549
    Abstract: Solutions are described which are useful as plasma expanders and blood substitutes in mammals, including primates, and methods for using the solutions.
    Type: Grant
    Filed: May 4, 2000
    Date of Patent: January 14, 2003
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Harold D. Waitz, Hal Sternberg, Judith M. Segall
  • Patent number: 6444418
    Abstract: Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
    Type: Grant
    Filed: July 18, 1997
    Date of Patent: September 3, 2002
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Patent number: 6410218
    Abstract: Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: June 25, 2002
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Patent number: 6406839
    Abstract: Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
    Type: Grant
    Filed: June 3, 1999
    Date of Patent: June 18, 2002
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Patent number: 6387612
    Abstract: Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: May 14, 2002
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall
  • Publication number: 20020025562
    Abstract: Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
    Type: Application
    Filed: June 3, 1999
    Publication date: February 28, 2002
    Inventors: PAUL E. SEGALL, HAL STERNBERG, HAROLD D. WAITZ, JUDITH M. SEGALL
  • Publication number: 20020012957
    Abstract: Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
    Type: Application
    Filed: July 18, 1997
    Publication date: January 31, 2002
    Inventors: PAUL E. SEGALL, HAL STERNBERG, HAROLD D. WAITZ, JUDITH M. SEGALL
  • Publication number: 20020009783
    Abstract: Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.
    Type: Application
    Filed: March 31, 1998
    Publication date: January 24, 2002
    Inventors: PAUL E. SEGALL, HAL STERNBERG, HAROLD D. WAITZ, JUDITH M. SEGALL
  • Patent number: 6300322
    Abstract: Artificial plasma-like solutions and methods for their use are provided. The subject solutions include: electrolytes and an oncotic agent. The subject solutions find use in a variety of applications, particularly in those applications where at least a portion of a host's blood volume is replaced with a blood substitute.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: October 9, 2001
    Assignee: BioTime, Inc.
    Inventors: Paul E. Segall, Hal Sternberg, Harold D. Waitz, Judith M. Segall