Patents by Inventor Harold Graboyes

Harold Graboyes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing cimetidine polymorph B
    Patent number: 4786735
    Abstract: A novel process for preparing cimetidine polymorph "B" comprises precipitating cimetidine from an aqueous-alcoholic solution of an acid addition salt. The precipitation is conducted at a temperature of above 15.degree. C.
    Type: Grant
    Filed: July 27, 1987
    Date of Patent: November 22, 1988
    Assignee: Smithkline Beckman Corporation
    Inventors: Harold Graboyes, David S. Kirkpatrick
  • Benzyl 5-methyl-4-imidazolecarboxylate
    Patent number: 4374252
    Abstract: A process for the preparation of 5-methyl-4-imidazolecarboxylic acid esters from acetoacetic acid esters. The products of this process are useful as intermediates for preparing cimetidine.
    Type: Grant
    Filed: December 10, 1981
    Date of Patent: February 15, 1983
    Assignee: SK&F Lab Co.
    Inventors: Harold Graboyes, Thomas J. Kasper, Praful D. Vaidya
  • Process for preparing 5-methyl-4-imidazolecarboxylic acid esters
    Patent number: 4328349
    Abstract: A process for the preparation of 5-methyl-4-imidazolecarboxylic acid esters from acetoacetic acid esters. The products of this process are useful as intermediates for preparing cimetidine.
    Type: Grant
    Filed: October 8, 1980
    Date of Patent: May 4, 1982
    Assignee: SK&F Lab Co.
    Inventors: Harold Graboyes, Thomas J. Kasper, Praful D. Vaidya
  • Method for preparing ticrynafen
    Patent number: 4107179
    Abstract: A new method for preparing ticrynafen comprises reacting 2,3-dichloro-4-hydroxyphenyl-2-thienylmethanone with an alkali metal salt of chloro or bromo acetic acid in aqueous solvent. An advantageous aspect of the reaction is that yields are increased with the addition of an alkali metal iodide to the reaction mixture.
    Type: Grant
    Filed: August 22, 1977
    Date of Patent: August 15, 1978
    Assignee: SmithKline Corporation
    Inventor: Harold Graboyes