Patents by Inventor Harold I. Weingarten

Harold I. Weingarten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel thiopeptolide substrates for vertebrate collagenase
    Patent number: 4596675
    Abstract: The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences:R-Pro-X-Gly-S-Y-Z-Gly-R.sub.1whereinR=H or N-protecting group,X=Leu, Ile, Phe, Val, Gln, Ala,Y=Leu, Ile, Phe, Val, Ala,Z=Leu, Ile, Phe, Val, Gln, Ala, andR.sub.1 =terminal amide, carboxyl or ester group.
    Type: Grant
    Filed: September 25, 1985
    Date of Patent: June 24, 1986
    Assignee: Monsanto Company
    Inventors: Harold I. Weingarten, Joseph Feder
  • Thiopeptolide substrates for vertebrate collagenase
    Patent number: 4569907
    Abstract: The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences:R-Pro-X-Gly-S-Y-Z-Gly-R.sub.1whereinR=H or N-protecting group,X=Leu, Ile, Phe, Val, Gln, Ala,Y=Leu, Ile, Phe, Val, Ala,Z=Leu, Ile, Phe, Val, Gln, Ala, andR.sub.1 =terminal amide, carboxyl or ester group.
    Type: Grant
    Filed: January 16, 1984
    Date of Patent: February 11, 1986
    Assignee: Monsanto Company
    Inventors: Harold I. Weingarten, Joseph Feder
  • Determination of collagenase by reacting with peptide substrates
    Patent number: 4507389
    Abstract: Synthetic peptide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences:R.sub.1 -Pro-Leu-Gly-Leu-Leu-Gly-R.sub.2andR.sub.1 -Pro-Leu-Gly-Leu-Ala-Gly-R.sub.2,whereinR.sub.1 =H or N-protecting group, andR.sub.2 =terminal amide, carboxyl or ester group. These peptide substrates are useful for determining collagenase activity.
    Type: Grant
    Filed: March 16, 1984
    Date of Patent: March 26, 1985
    Assignee: Monsanto Company
    Inventor: Harold I. Weingarten
  • Peptide substrates for mammalian collagenase
    Patent number: 4466919
    Abstract: The disclosure relates to novel synthetic peptide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences:R.sub.1 -Pro-Leu-Gly-Leu-Leu-Gly-R.sub.2andR.sub.1 -Pro-Leu-Gly-Leu-Ala-Gly-R.sub.2,whereinR.sub.1 =H or N-protecting group, andR.sub.2 =terminal amide, carboxyl or ester group.
    Type: Grant
    Filed: December 16, 1982
    Date of Patent: August 21, 1984
    Assignee: Monsanto Company
    Inventor: Harold I. Weingarten
  • Peptide and peptolide substrates for mammalian collagenase
    Patent number: 4443367
    Abstract: The disclosure relates to novel synthetic peptide and peptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences:R.sub.1 --Pro--Leu--Gly--Ile--Leu--Gly--Leu--R.sub.2,R.sub.1 --Gly--Pro--Leu--Gly--Ile--Leu--Gly--Ala--R.sub.2,R.sub.1 --Pro--Leu--Gly(O--Ile)--Leu--R.sub.2,R.sub.1 --Pro--Leu--Gly(O--Leu)--Leu--R.sub.2, andR.sub.1 --Pro--Leu--Gly(O--Leu)--Ala--R.sub.2,whereinR.sub.1 =H or N-protecting group, andR.sub.2 =terminal amide, carboxyl or ester group.
    Type: Grant
    Filed: April 8, 1982
    Date of Patent: April 17, 1984
    Assignee: Monsanto Company
    Inventor: Harold I. Weingarten
  • Novel peptide and peptolide substrates for mammalian collagenase
    Patent number: 4425428
    Abstract: Method for determination of the enzyme collagenase by reacting the enzyme with a peptide or peptolide substrate having the following amino acid sequences:R.sub.1 -Pro-Leu-Gly-Ile-Leu-Gly-Leu-R.sub.2,R.sub.1 -Gly-Pro-Leu-Gly-Ile-Leu-Gly-Ala-R.sub.2,R.sub.1 -Pro-Leu-Gly(O-Ile)-Leu-R.sub.2,R.sub.1 -Pro-Leu-Gly(O-Leu)-Leu-R.sub.2, andR.sub.1 -Pro-Leu-Gly(O-Leu)-Ala-R.sub.2,wherein R.sub.1 is H or N-protecting group, and R.sub.2 is terminal amide, carboxyl or ester group.
    Type: Grant
    Filed: April 18, 1983
    Date of Patent: January 10, 1984
    Assignee: Monsanto Company
    Inventor: Harold I. Weingarten