Abstract: A system is provided for determining the position of an interventional device inside a lumen. The interventional device comprises a distal portion inside the lumen and a proximal portion outside the lumen and the system comprises a processor. The processor is configured to receive a first estimated position of the distal portion of the interventional device inside the lumen from a first system and receive an estimated displacement of the distal portion of the interventional device inside a lumen from a second system, wherein the estimated displacement is representative of the movement of the distal portion of the interventional device inside the lumen. The processor is further configured to determine a second estimated position of the distal portion of the interventional device inside the lumen based on the first estimated position and the estimated displacement.

Abstract: Systems, computer program products, and methods are described herein for virtualization of non-fungible tokens. The present invention is configured to receive, via a first user input device, a resource transfer request using a virtual token from a first user, wherein the virtual token is electronically linked to an NFT of a resource transfer instrument; retrieve the NFT associated with the resource transfer instrument in response to receiving the resource transfer request; retrieve an NFT credential descriptor for the resource transfer request from a first metadata layer of the NFT associated with the resource transfer instrument; receive an authentication credential from the first user; determine whether the authentication credential matches an NFT credential descriptor that is electronically linked to the NFT associated with the resource transfer instrument; and authorize the resource transfer request based on at least determining that the authentication credential matches an NFT credential descriptor.

Abstract: Methods and devices for treating skin include a skin-contacting portion, an actuator and a processor, wherein activation of the actuator causes surface acoustic waves of Rayleigh, “pseudo” Rayleigh types to be produced on the skin around the actuator. In a location which is under the actuator, the actuator produces tension and repulsion of skin particles. These surface acoustic waves can be used to provide treatment to the skin, including wound healing, non-adhesion of bandages, reduced infection, reduced pain and cosmetic enhancements. The skin-contacting portion may be a patch or bandage, a glove, a hand-held device, or any other suitable configuration. The actuator is incorporated into the skin-contacting portion.

Abstract: Methods and systems are provided for treatment of medical devices using surface acoustic waves (SAW) of Rayleigh, “pseudo” Rayleigh and Lamb type. In some embodiments, use of such SAW is controlled such that relative velocity of bacteria is achieved wherein the vibration amplitude of the bacteria is smaller than a Z-potential repulsive zone of the bacteria, thus preventing biofilm formation on the medical devices. In some embodiments, systems of the present invention are powered by body movements, and may also provide a feedback loop for control of parameters. In some embodiments, the medical devices of the present invention are comprised of piezoelectric material, and act as self-actuators for the system.

Abstract: The invention relates to an in vivo sensing device having a specific gravity of about 1 or a volume to weight ratio that enables it essentially to float. In one embodiment the in vivo sensing device consists of an image sensor system and a buoyant body. The buoyant body, which is attached to the sensor system or which can optionally house one or more elements of the sensor system, keeps the sensor system essentially floating in a body lumen liquid.

Abstract: An apparatus, system and methods thereof for generating an acoustic lubrication effect along a surface of an in-dwelling medical device that is in contact with a vital tissue in a subject are provided. The vibrations comprise: Hz range cylindrical surface vibrations; or kHz range surface acoustic wave (SAW) vibrations; or a combination thereof. The vibrations create an acoustic lubrication effect that may reduce pain or discomfort in a subject when the apparatus is used with an indwelling medical device. The vibrations may enhance tactile sensation when the medical device is a shoe pad.

Abstract: A urinary catheter clip-on device applies surface acoustic waves of Rayleigh-Lamb and/or Love type to a urinary catheter for preventing biofilms on the catheter surfaces. The bacteria is forced to move relative to the vibrating catheter surface. The amplitudes of bacteria vibrations are in nanometer range. The relative motion of bacteria results in bacteria quorum sensing, and disrupts the bacteria attachment process. The method is preventive as surface acoustic waves create low acoustic energy and bacteria is not killed.

Abstract: An in vivo device, such as an in vivo imaging device or other sensing device, may include a device body and at least one appendage coupled to the device body. According to some embodiments the appendage(s) may be extended or expanded, or reduced or removed, in vivo, thereby altering the device geometry while in a body lumen.

Abstract: A moveable in vivo device comprises a device body and at least one moveable appendage that is moveably coupled the device body such that movement of the moveable appendage causes the device body to move in a body lumen.

Abstract: A urinary catheter clip-on device applies surface acoustic waves of Rayleigh-Lamb and/or Love type to a urinary catheter for preventing biofilms on the catheter surfaces. The bacteria is forced to move relative to the vibrating catheter surface. The amplitudes of bacteria vibrations are in nanometer range. The relative motion of bacteria results in bacteria quorum sensing, and disrupts the bacteria attachment process. The method is preventive as surface acoustic waves create low acoustic energy and bacteria is not killed.

Abstract: Methods and devices for treating skin include a skin-contacting portion, an actuator and a processor, wherein activation of the actuator causes surface acoustic waves of Rayleigh, “pseudo” Rayleigh types to be produced on the skin around the actuator. In a location which is under the actuator, the actuator produces tension and repulsion of skin particles. These surface acoustic waves can be used to provide treatment to the skin, including wound healing, non-adhesion of bandages, reduced infection, reduced pain and cosmetic enhancements. The skin-contacting portion may be a patch or bandage, a glove, a hand-held device, or any other suitable configuration. The actuator is incorporated into the skin-contacting portion.

Abstract: Methods and systems are provided for treatment of medical devices using surface acoustic waves (SAW) of Rayleigh, “pseudo” Rayleigh and Lamb type. In some embodiments, use of such SAW is controlled such that relative velocity of bacteria is achieved wherein the vibration amplitude of the bacteria is smaller than a Z-potential repulsive zone of the bacteria, thus preventing biofilm formation on the medical devices. In some embodiments, systems of the present invention are powered by body movements, and may also provide a feedback loop for control of parameters. In some embodiments, the medical devices of the present invention are comprised of piezoelectric material, and act as self-actuators for the system.

Abstract: The invention relates to an in vivo sensing device having a specific gravity of about 1 or a volume to weight ratio that enables it essentially to float. In one embodiment the in vivo sensing device consists of an image sensor system and a buoyant body. The buoyant body, which is attached to the sensor system or which can optionally house one or more elements of the sensor system, keeps the sensor system essentially floating in a body lumen liquid.

Abstract: The invention relates to an in vivo sensing device having a specific gravity of about 1 or a volume to weight ratio that enables it essentially to float. In one embodiment the in vivo sensing device consists of an image sensor system and a buoyant body. The buoyant body, which is attached to the sensor system or which can optionally house one or more elements of the sensor system, keeps the sensor system essentially floating in a body lumen liquid.

Abstract: Pharmaceutical compositions of probiotic E. coli strains and uses thereof for treating inflammatory bowel disease.

Abstract: Multi-lumen catheters are intended for advancement through the accessory channel on endoscope into a body passage into the gastrointestinal system. The catheters have two or more independent lumens extending continuously to ports at the distal tip for injection of a contrast medium simultaneously with a guide wire for ERCP procedures and for passage of accessories such as visualization devices, polypectomy snares, cytology brushes, papillotomes and stone baskets for catheterization, diagnosis and treatment within the biliary tract. Use of balloons for maintaining a catheter in fixed position in the biliary tract and for dilatation is also disclosed. The catheters employed are extrusions of a resin comprised of nylon and PEBA. The catheters may also be extruded from polyurethane. Multi-lumen catheters having a reduced diameter distal tip portion on which a dilatation balloon is located are also disclosed. The reduced diameter distal tip portion may serve as a platform for support of a stent.

Abstract: Pharmaceutical compositions of probiotic E. coli strains and uses thereof for treating inflammatory bowel disease.

Abstract: An in vivo device, such as an in vivo imaging device or other sensing device, may include a device body and at least one appendage coupled to the device body. According to some embodiments the appendage(s) may be extended or expanded, or reduced or removed, in vivo, thereby altering the device geometry while in a body lumen.

Abstract: A low-flow metering device 10 for measuring the flow of an amount of liquid exceeding 0.05 ml., in which a first chamber 12 has an inlet 14, and an outlet 16 in fluid communication with a second chamber 17, the first chamber 12 containing an element 22 creating a laminar flow 24. The outlet 16 of the first chamber is provided with a drop generator 19 leading to the second chamber 17 and is sized to release a series of droplets 18, each of the droplets forming and breaking away under its own weight from liquid in the drop generator orifice. An overflow conduit 21 extends between an upper area of the first chamber 12 and a lower area of the second chamber 17 for equalizing gas pressure between the two chambers 12, 17. An electronic system 28 is positioned in the second chamber 17 below the drop generator 19 for counting the passage of each droplet 18 exiting therefrom, and an information processing unit 32 is connected to the electronic system 28 for receiving and recording information.

Abstract: A device, which comprises a surface layer that has incorporated therein at least one radioactive nuclide. The surface layer is a self-assembled layer, particularly an anchored SAM that is selected from the group consisting of monolayers or films anchored by siloxane, thiol, amine or phosphonate. The surface layer may be formed of a radioactive material that has been activated to induce radioactivity therein after its final formation. The device may comprise a chemically functionalized SAM incorporating radionuclides attached at the surface of the device. The device may be a temporary or permanent therapeutic implant, such as a stent.