Patents by Inventor Harold Mastalerz

Harold Mastalerz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • C-5 Modified indazolylpyrrolotriazines
    Publication number: 20050209235
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: May 9, 2005
    Publication date: September 22, 2005
    Inventors: Harold Mastalerz, Guifen Zhang, James Tarrant, Gregory Vite
  • Di-substituted pyrrolotrizine compounds
    Publication number: 20050197339
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents for the treatment of cancer and other diseases.
    Type: Application
    Filed: December 22, 2004
    Publication date: September 8, 2005
    Inventors: Ashvinikumar Gavai, Wen-Ching Han, Ping Chen, Edward Ruediger, Harold Mastalerz, Brian Fink, Derek Norris
  • Pyrrolotriazine compounds as kinase inhibitors
    Publication number: 20050182058
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: December 22, 2004
    Publication date: August 18, 2005
    Inventors: Brian Fink, Ashvinikumar Gavai, Gregory Vite, Ping Chen, Harold Mastalerz, Derek Norris, John Tokarski, Yufen Zhao, Wen-Ching Han
  • Process for the preparation of C-4 carbonate taxanes
    Patent number: 6916942
    Abstract: A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: July 12, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: John F. Kadow, Harold Mastalerz, Joydeep Kant, Qiufen May Xue, James G. Tarrant
  • C-6 modified indazolylpyrrolotriazines
    Patent number: 6916815
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: July 12, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory D. Vite, Ashvinikumar V. Gavai, Brian E. Fink, Harold Mastalerz, John F. Kadow
  • C-5 modified indazolylpyrrolotriazines
    Patent number: 6908916
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Grant
    Filed: November 14, 2002
    Date of Patent: June 21, 2005
    Assignee: Bristol Myers Squibb Company
    Inventors: Harold Mastalerz, Guifen Zhang, James G. Tarrant, Gregory D. Vite
  • Process for the preparation of C-4 carbonate taxanes
    Publication number: 20040225009
    Abstract: A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents.
    Type: Application
    Filed: April 19, 2004
    Publication date: November 11, 2004
    Inventors: John F. Kadow, Harold Mastalerz, Joydeep Kant, Qiufen May Xue, James G. Tarrant
  • C-6 modified indazolylpyrrolotriazines
    Publication number: 20040142931
    Abstract: The present invention provides compounds of formula I 1
    Type: Application
    Filed: December 15, 2003
    Publication date: July 22, 2004
    Inventors: Gregory D. Vite, Ashvinikumar V. Gavai, Brian E. Fink, Harold Mastalerz, John F. Kadow
  • C-4 carbonate taxanes
    Patent number: 6750246
    Abstract: The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations. The invention claims compounds of formula I and the use of compounds of formula I or pharmaceutical salts thereof as oral drugs for the treatment of human or veterinary disease. in which: R is phenyl, isopropyl, or tert butyl; R1 is —C(O)Rz in which Rz is (CH3)3CO—, (CH3)3CCH2—, CH3(CH2)3O—, cyclobutyl-, cyclohexyloxy, or (2-furyl); R2 is CH3C(O)O—.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: June 15, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: John F. Kadow, Harold Mastalerz, Qiufen May Xue, Steven Hansel, Mary Edson Zoeckler, William C. Rose, James G. Tarrant
  • C-5 Modified indazolylpyrrolotriazines
    Publication number: 20030186983
    Abstract: The present invention provides compounds of formula I 1
    Type: Application
    Filed: November 14, 2002
    Publication date: October 2, 2003
    Inventors: Harold Mastalerz, Guifen Zhang, James G. Tarrant, Gregory D. Vite
  • 7-sulfur substituted paclitaxels
    Patent number: 6017935
    Abstract: The present invention relates to novel taxane derivatives wherein, the taxol ring is substituted by sulfur groups on the C-7, their use as antitumor agents and pharmaceutical formulations.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: January 25, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Harold Mastalerz, John F. Kadow
  • 6-thio-substituted paclitaxels
    Patent number: 5977386
    Abstract: The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: November 2, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Andrew J. Staab, John F. Kadow, Dolatrai M. Vyas, Mark D. Wittman, Harold A. Mastalerz