Patents by Inventor Harold Meckler

Harold Meckler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240002358
    Abstract: The present invention describes chemical processes for making optically-clear, taste-masked, shelf-stable nano-emulsions containing essentially pure cannabinoids and other nutraceuticals.
    Type: Application
    Filed: September 12, 2023
    Publication date: January 4, 2024
    Inventors: Harold Meckler, Marcus Brackeen, Kyle Olson
  • Publication number: 20230321010
    Abstract: The invention also relates to processes for producing abuse deterrent pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Application
    Filed: March 31, 2023
    Publication date: October 12, 2023
    Applicant: CHEMAPOTHECA, LLC
    Inventors: KARL POPP, HAROLD MECKLER
  • Patent number: 11717498
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: August 8, 2023
    Assignees: Pharmapotheca A, Inc., Chemapotheca, LLC
    Inventors: Karl Popp, Harold Meckler
  • Publication number: 20230149342
    Abstract: The present invention describes a method which outlines a process for conversion of CBD to a ?9-tetrahydrocannabinol (?9-THC) compound or derivative thereof involving treating a naturally produced CBD intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the ?9-tetrahydrocannabinol compound or derivative thereof at a relatively high concentration. The source of the CBD is from industrial hemp having less than 0.3% ?9-THC and extracting and purifying a CBD distillate or isolate or a combination thereof. This procedure will produce ?9-THC that is essentially free from any other cannabinoids other than some trace amounts of the initial CBD starting material, or about 95% ?9-THC and 2-4% CBD. Another aspect of the present invention relates to a process for further purification and enrichment of the ?9-THC using distillation and collecting an essentially pure fraction of ?9-THC using additional distillation or enrichment form of purification.
    Type: Application
    Filed: November 9, 2021
    Publication date: May 18, 2023
    Inventors: KYLE OLSON, HAROLD MECKLER, MARCUS BRACKEEN, MARIO TREMBLAY
  • Publication number: 20220162153
    Abstract: This is invention is related to processes for synthesis of levoamphetamine derivatives and novel intermediates thereby, and processes for using the same.
    Type: Application
    Filed: March 2, 2020
    Publication date: May 26, 2022
    Inventors: HAROLD MECKLER, PRAVEEN SURYADEVARA, MARCUS BRACKEEN, DARRYL CLEARY
  • Patent number: 11123310
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: September 21, 2021
    Assignees: Pharmapotheca, LLC, Chemapotheca, LLC
    Inventors: Karl Popp, Harold Meckler
  • Publication number: 20210030699
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Application
    Filed: October 9, 2020
    Publication date: February 4, 2021
    Applicants: Pharmapotheca, LLC, Chemapotheca, LLC
    Inventors: KARL POPP, HAROLD MECKLER
  • Publication number: 20200352883
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Application
    Filed: July 29, 2020
    Publication date: November 12, 2020
    Applicants: CHEMAPOTHECA, LLC, PHARMAPOTHECA, LLC
    Inventors: Karl Popp, Harold Meckler
  • Patent number: 10087202
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: April 5, 2017
    Date of Patent: October 2, 2018
    Assignee: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Gregg, Jie Yang
  • Publication number: 20180243241
    Abstract: The invention also relates to pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.
    Type: Application
    Filed: February 24, 2017
    Publication date: August 30, 2018
    Inventors: Karl Popp, Harold Meckler
  • Publication number: 20170210768
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions,
    Type: Application
    Filed: April 5, 2017
    Publication date: July 27, 2017
    Inventors: HAROLD MECKLER, BRIAN GREGG, JIE YANG
  • Patent number: 9657041
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: May 23, 2017
    Assignee: Chemapotheca, LLC
    Inventors: Harold Meckler, Brian Gregg, Jie Yang
  • Publication number: 20160207945
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions,
    Type: Application
    Filed: March 7, 2016
    Publication date: July 21, 2016
    Inventors: HAROLD MECKLER, BRIAN GREGG, JIE YANG
  • Patent number: 9321794
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: April 26, 2016
    Assignee: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Patent number: 9278904
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: March 8, 2016
    Assignee: Chemapotheca, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Publication number: 20150183810
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions.
    Type: Application
    Filed: July 9, 2014
    Publication date: July 2, 2015
    Applicant: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Publication number: 20150183716
    Abstract: The invention includes processes for the synthesis of amphetamine, dexamphetamine, methamphetamine, derivatives of these, including their salts, and novel precursors and intermediates obtained thereby, by synthesizing aziridine phosphoramidate compounds in specified solvents at specified temperatures, and then converting to a novel aryl or aryl-alkyl phosphoramidate precursors using an organometallic compound such as a copper salt, where the novel aryl or aryl-alkyl phosphoramidate precursor is then easily converted to the target compounds using known reactions,
    Type: Application
    Filed: February 25, 2014
    Publication date: July 2, 2015
    Applicant: CHEMAPOTHECA, LLC
    Inventors: Harold Meckler, Brian Thomas Gregg, Jie Yang
  • Patent number: 8334266
    Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: December 18, 2012
    Assignee: Telik, Inc.
    Inventors: William A. Boulanger, Steven J. Collier, Stephen A. Eastham, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernandez Abad, R. Jason Herr, Hans J. Kjaersgaard, Harold Meckler, Robert E. Polomski, Steven R. Schow, Pavel E. Zhichkin
  • Publication number: 20120238772
    Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
    Type: Application
    Filed: March 23, 2012
    Publication date: September 20, 2012
    Inventors: William A. Boulanger, Steven J. Collier, Stephen A. Eastham, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernández Abad, R. Jason Herr, Hans J. Kjaersgaard, Harold Meckler, Robert E. Polomski, Steven R. Schow, Pavel E. Zhichkin
  • Patent number: 8198247
    Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
    Type: Grant
    Filed: December 21, 2004
    Date of Patent: June 12, 2012
    Assignee: Telik, Inc.
    Inventors: William A. Boulanger, Dennis L. Edie, Ronan Y. Guevel, Pedro E. Hernandez Abad, R. Jason Herr, Harold Meckler, Steven R. Schow, Pavel E. Zhichkin