Patents by Inventor Harold N. Weller, III

Harold N. Weller, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinazolinone inhibitors of cGMP phosphodiesterase
    Patent number: 6087368
    Abstract: Novel quinazolinone compounds, methods of using such compounds in the treatment of cGMP-associated conditions such as erectile dysfunction, and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: July 11, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: John E. Macor, David P. Rotella, Harold N. Weller, III, David W. Cushman, Joseph P. Yevich
  • Non-peptidic angiotensin-II-receptor-antagonists
    Patent number: 5378704
    Abstract: Novel compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, X and Y are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: April 15, 1992
    Date of Patent: January 3, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Harold N. Weller, III
  • Oxadiazinone substituted indole and benzimidazole derivatives
    Patent number: 5236916
    Abstract: Novel compounds having the formula ##STR1## wherein X, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.
    Type: Grant
    Filed: May 26, 1992
    Date of Patent: August 17, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Michael A. Poss
  • Biphenyl oxadiazinone angiotensin II inhibitors
    Patent number: 5225408
    Abstract: Angiotension II inhibition is exhibited by ##STR1## wherein: R.sup.1 and R.sup.2 are each independently hydrogen, alkyl, aryl, aralkyl, cycloalkyl, cycloalkylalkyl, thiophenalkyl, pyridylalkyl, or --R.sup.8 CO.sub.2 R.sup.9 ;R.sup.3 is a single bond, --S--, or --O--;R.sup.4 is hydrogen, alkyl, alkenyl, alkynyl, aryl, cycloalkyl, aralkyl, cycloalkylalkyl, or thiophenalkyl;R.sup.7 --(CH.sub.2).sub.n --CO.sub.2 R.sup.9, ##STR2## --NHSO.sub.2 CF.sub.3, --SO.sub.3 H, --C(CF.sub.3).sub.2 OH, ##STR3## --PO.sub.3 H, ##STR4## --CONHOR.sup.12, --CONHNHSO.sub.2 CF.sub.3, --(CH.sub.2).sub.n --5--tetrazolyl (optionally substituted with R.sup.9), and the remaining symbols are as defined in the specification.
    Type: Grant
    Filed: December 20, 1991
    Date of Patent: July 6, 1993
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Harold N. Weller, III
  • N-heterocyclic alcohol derivatives
    Patent number: 5151513
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is an N-heterocyclic group as defined herein, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
    Type: Grant
    Filed: April 29, 1988
    Date of Patent: September 29, 1992
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Denis E. Ryono
  • N-morpholino derivatives and their use as anti-hypertensive agents
    Patent number: 5055466
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: October 8, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Denis E. Ryono
  • Ester substituted aminoalkanoylureido amino and imino acid and ester compounds
    Patent number: 5013861
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as intermediates in the preparation of pharmaceutically active products.
    Type: Grant
    Filed: October 6, 1986
    Date of Patent: May 7, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • N-heterocyclic alcohol derivatives
    Patent number: 4981843
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is an N-heterocyclic group as defined herein and Y can be --NH--, --O-- or --CH.sub.2 --, are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
    Type: Grant
    Filed: April 7, 1988
    Date of Patent: January 1, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Harold N. Weller, III
  • N-heterocyclic alcohol renin inhibitors
    Patent number: 4885292
    Abstract: Compounds of the formula ##STR1## are disclosed wherein R.sub.1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are useful as antihypertensive agents.
    Type: Grant
    Filed: June 29, 1989
    Date of Patent: December 5, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Ryono, Harold N. Weller, III
  • Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides
    Patent number: 4849525
    Abstract: Compounds of the formula ##STR1## and their pharmaceutically acceptable salts wherein Z completes a cycloalkyl ring, a substituted cycloalkyl ring, a cycloalkenyl ring, a substituted cycloalkenyl ring or a saturated heteroalkyl ring; R.sub.2 is lower alkyl, aralkyl or aminoalkyl and X is an amino or imino acid. The compounds possess angiotensin converting enzyme inhibition activity.
    Type: Grant
    Filed: September 21, 1987
    Date of Patent: July 18, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Ureidoalkanoylaminocarbonyl amino and imino acids and esters
    Patent number: 4818757
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: December 28, 1987
    Date of Patent: April 4, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Ureidoalkanoylaminocarbonyl amino and imino acids and esters
    Patent number: 4810791
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definintion of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: December 28, 1987
    Date of Patent: March 7, 1989
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Ureidoalkanoylaminocarbonyl amino and imino acids and esters
    Patent number: 4740508
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: April 22, 1985
    Date of Patent: April 26, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
    Patent number: 4642315
    Abstract: Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
    Type: Grant
    Filed: October 22, 1984
    Date of Patent: February 10, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Harold N. Weller, III
  • Ester substituted aminoalkanoylureido amino and imino acid and ester compounds
    Patent number: 4638010
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
    Type: Grant
    Filed: February 28, 1985
    Date of Patent: January 20, 1987
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon
  • Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
    Patent number: 4587234
    Abstract: Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
    Type: Grant
    Filed: October 22, 1984
    Date of Patent: May 6, 1986
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Harold N. Weller, III
  • Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides
    Patent number: 4560506
    Abstract: Compounds of the formula ##STR1## wherein A is a cycloalkyl ring, a substituted cycloalkyl ring, a phenyl ring, or a substituted phenyl ring and ##STR2## are various dipeptide groups are disclosed. The compounds possess angiotensin converting enzyme inhibition activity and depending upon the terminal amino acid may also possess enkephalinase inhibition activity.
    Type: Grant
    Filed: May 25, 1984
    Date of Patent: December 24, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon, Norma G. Delaney
  • Acylamino oxo or hydroxy substituted alkylamino thiazines and thiazepines
    Patent number: 4512988
    Abstract: Compounds of the formula ##STR1## and X is an oxo substituted thiazine or thiazepine are disclosed. These compounds possess angiotensin converting enzyme inhibition activity and are thus useful as hypotensive agents.
    Type: Grant
    Filed: March 1, 1984
    Date of Patent: April 23, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon, Donald S. Karanewsky, Denis E. Ryono
  • Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
    Patent number: 4499079
    Abstract: Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
    Type: Grant
    Filed: November 18, 1982
    Date of Patent: February 12, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Eric M. Gordon, Harold N. Weller, III
  • Carboxy and substituted carboxy aroly peptides
    Patent number: 4456595
    Abstract: Peptides of the formula ##STR1## wherein X is various amino or imino acids or esters are useful as hypotensive agents.
    Type: Grant
    Filed: December 6, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Eric M. Gordon