Abstract: Novel compounds that modulate PDE10A, a gene that is primarily expressed in medium spiny neurons of the mammalian striatum and has been found to inhibit striatal output by reducing spiny medium excitability and effect cAMP and cGMP signalling cascades in vivo in rats, and methods for treating psychosis and schizophrenia using the novel compounds. Methods for screening for further compounds to modulate PDE10A activity are also taught.

Abstract: A vehicle motor includes a plurality of in-line electric motors and a high-speed pulley system including a plurality of pulleys. The motor further includes a direct current mechanism and an alternating current mechanism for selectively supplying power and accelerating the vehicle. The alternating current mechanism includes primary and secondary circuits for adjusting the current and voltage level of the system. The alternating current mechanism further includes a high-energy variable-voltage transformer to convert variations of a first current in the primary circuit into variations of a voltage and a second current in the secondary circuit. The alternating current mechanism further includes an alternator for sending alternating current from the transformer to another of the plurality of motors. The motor further includes a mechanism for automatically regulating an operating mode of the system so that the alternating current mechanism is inactive when the direct current mechanism is active and vice versa.

Abstract: PDE10A, a gene that is normally highly expressed in mammalian striatum and elsewhere, has been found to decrease in expression during the development of CAG repeat disorders such as Huntington's disease. The invention teaches a method for detecting the presence of or the predisposition for a CAG repeat disorder. Compounds which modulate CAG repeat disorders and their uses are taught. Methods for screening for further compounds to modulate CAG repeat disorders are also taught.