Patents by Inventor Harold Swerdlow

Harold Swerdlow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180298358
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Application
    Filed: June 26, 2018
    Publication date: October 18, 2018
    Applicant: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Patent number: 10017750
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Grant
    Filed: August 25, 2016
    Date of Patent: July 10, 2018
    Assignee: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Publication number: 20160362664
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Application
    Filed: August 25, 2016
    Publication date: December 15, 2016
    Applicant: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Patent number: 9447389
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogs bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: September 20, 2016
    Assignee: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Publication number: 20150024463
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Application
    Filed: September 3, 2014
    Publication date: January 22, 2015
    Applicant: ILLUMINA CAMBRIDGE LIMITED
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches-Kuiper, Harold Swerdlow, David James Earnshaw
  • Patent number: 8460910
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: June 11, 2013
    Assignee: Illumina Cambridge Limited
    Inventors: Geoffrey Paul Smith, David Mark Dunstan Bailey, Raquel Maria Sanches, Harold Swerdlow, David James Earnshaw
  • Patent number: 8241573
    Abstract: The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
    Type: Grant
    Filed: March 30, 2007
    Date of Patent: August 14, 2012
    Assignee: Illumina, Inc.
    Inventors: Saibal Banerjee, Colin Barnes, Kevin Benson, Jason Bryant, Dale Buermann, Sergey Etchin, Johnny Ho, Xavier Lee, Peter Lundberg, Klaus Maisinger, Bojan Obradovic, Mark Pratt, Mark Reed, Chiara Rodighiero, Subra Sankar, Harold Swerdlow, Eric Vermaas
  • Patent number: 8139288
    Abstract: A prism for use in scanning applications such as total internal reflection microscopy in which the prism is translated relative to an incident light beam. A geometry is disclosed which cancels walk of the beam footprint at the base of the prism. Walk of the beam footprint due to irregularities in a largely planar sample surface located at the prism base are cancelled by coupling movement of the incident light beam to movement of the sample in the field of view of an objective lens, for example as part of an autofocus arrangement.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: March 20, 2012
    Assignee: Illumina Cambridge Limited
    Inventors: Mark Osborne, Jason Bryant, Bojan Obradovic, Harold Swerdlow
  • Patent number: 7731827
    Abstract: The invention relates to a method for capturing charged molecules of interest traveling in an electrolyte flow stream through an electrically non-conductive channel, comprising at least one anode and at least one cathode individually separated from said channel, but in electrical contact with said flow stream, by a conductive ion selective semi-permeable membrane. Said membrane interferes with the normal migration of ions towards its respective electrode, generating at least two zones of different electric field. Balance between hydrodynamic and electrical forces captures certain ions into the flow stream. it also relates to a device for performing the method.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: June 8, 2010
    Assignees: PerkinElmer Health Sciences, Inc., Biomotif AB, Hans Jornvall
    Inventors: Juan Astorga-Wells, Sang-Ryoul Park, Harold Swerdlow, Gerald Jesson, Ulf Lindberg, Tomas Bergman, Hans Jornvall, Mats Jonsson
  • Publication number: 20100111768
    Abstract: The present invention comprises systems and devices for sequencing of nucleic acid, such as short DNA sequences from clonally amplified single-molecule arrays.
    Type: Application
    Filed: March 30, 2007
    Publication date: May 6, 2010
    Applicant: SOLEXA, INC.
    Inventors: Saibal Banerjee, Colin Barnes, Kevin Benson, John Bridgham, Jason Bryant, Dale Buermann, Sergey Etchin, Jonny Ho, Xavier Lee, Peter Lundberg, Klaus Maisinger, Bojan Obradovic, Mark Pratt, Isabelle Rasolonjatovo, Mark Reed, Chiara Rodighiero, Subra Sankar, Gary Schroth, Ning Sizto, Harold Swerdlow, Eric Vermaas
  • Publication number: 20090237670
    Abstract: There is disclosed a prism for use in scanning applications such as total internal reflection microscopy in which the prism is translated relative to an incident light beam. A geometry is disclosed which cancels walk of the beam footprint at the base of the prism. Walk of the beam footprint due to irregularities in a largely planar sample surface located at the prism base are cancelled by coupling movement of the incident light beam to movement of the sample in the field of view of an objective lens, for example as part of an autofocus arrangement.
    Type: Application
    Filed: March 6, 2009
    Publication date: September 24, 2009
    Inventors: Mark Osborne, Jason Bryant, Bojan Obradovic, Harold Swerdlow
  • Patent number: 7566537
    Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: July 28, 2009
    Assignee: Illumina Cambridge Limited
    Inventors: Shankar Balasubramanian, Colin Barnes, Xiaohai Liu, John Milton, Harold Swerdlow, Xiaolin Wu
  • Patent number: 7518764
    Abstract: There is disclosed a prism for use in scanning applications such as total internal reflection microscopy in which the prism is translated relative to an incident light beam. A geometry is disclosed which cancels walk of the beam footprint at the base of the prism. Walk of the beam footprint due to irregularities in a largely planar sample surface located at the prism base are cancelled by coupling movement of the incident light beam to movement of the sample in the field of view of an objective lens, for example as part of an autofocus arrangement.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: April 14, 2009
    Assignee: Solexa Limited
    Inventors: Mark Osborne, Jason Bryant, Bojan Obradovic, Harold Swerdlow
  • Patent number: 7427673
    Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
    Type: Grant
    Filed: December 4, 2002
    Date of Patent: September 23, 2008
    Assignee: Illumina Cambridge Limited
    Inventors: Shankar Balasubramanian, Colin Barnes, Xiaohai Liu, Harold Swerdlow
  • Publication number: 20070269806
    Abstract: The invention provides a hairpin polynucleotide, having a loop and a stem region, characterised in that a sulfur-based nucleophile is attached to an internal nucleotide in the hairpin through a linker to enable binding to a solid support.
    Type: Application
    Filed: November 8, 2004
    Publication date: November 22, 2007
    Inventors: Darren Ellis, Colin Barnes, Harold Swerdlow, Tom Brown
  • Publication number: 20060246449
    Abstract: There is disclosed a method for determining the identity of one or more mutations or single nucleotide polymorphisms (SNPs) in a genome, comprising: a contacting a sample genome, under conditions which permit template dependant oligonucleotide ligation, with a plurality of different oligonucleotide molecules which comprise (i) a first set of oligonucleotides each comprising a sequence of nucleotides that is complementary to a region on said genome that includes a known SNP site and which oligonucleotides are complementary to said region other than at a base at or near the 5? end of said oligonucleotides that is to be tested for complementarity to a base at the SNP site, each of said oligonucleotides comprising a unique label to identify both the base to be tested and the position of the SNP to be scored, (ii) a second set of oligonucleotides each comprising a sequence of nucleotides complementary to a region on said target genome for hybridisation with said target genome adjacent the 5? end of an oligonucleot
    Type: Application
    Filed: February 26, 2004
    Publication date: November 2, 2006
    Inventors: Harold Swerdlow, Colin Barnes, John Todd, Richard Durbin
  • Publication number: 20060240439
    Abstract: The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3? position of the sugar moiety that are larger in size than the naturally occurring 3? hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of DNA sequencing.
    Type: Application
    Filed: September 10, 2004
    Publication date: October 26, 2006
    Inventors: Geoffrey Smith, David Bailey, Raquel Sanches, Harold Swerdlow, David Earnshaw
  • Publication number: 20060188901
    Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
    Type: Application
    Filed: December 13, 2005
    Publication date: August 24, 2006
    Inventors: Colin Barnes, Shankar Balasubramanian, Xiaohai Liu, Harold Swerdlow, John Milton
  • Publication number: 20060160075
    Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
    Type: Application
    Filed: December 4, 2002
    Publication date: July 20, 2006
    Inventors: Shankar Balasubramanian, Colin Barnes, Xiaohai Liu, Harold Swerdlow
  • Patent number: 7057026
    Abstract: Nucleosides and nucleotides are disclosed that are linked to detectable labels via a cleavable linker group.
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: June 6, 2006
    Assignee: Solexa Limited
    Inventors: Colin Barnes, Shankar Balasubramanian, Xiaohai Liu, Harold Swerdlow, John Milton