Patents by Inventor Harold von Melchner

Harold von Melchner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Retrovirus promoter-trap vectors
    Patent number: 5627058
    Abstract: Retroviruses are used as genetic tools to isolate transcriptionally active chromosomal regions. The retroviruses have a promoterless protein coding sequence located in U3 or U5. The retroviruses may be used to infect cells under conditions which permit selection for instances when the retrovirus integrates in close proximity to and under the control of a cellular promoter. The promoter and its associated gene then may be identified and isolated. In this manner, the retroviruses function as promoter-traps. Related methods and products including vectors, kits and assays are provided.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: May 6, 1997
    Assignee: Massachusetts Institute of Technology
    Inventors: H. Earl Ruley, Harold von Melchner
  • Retrovirus promoter-trap vectors
    Patent number: 5364783
    Abstract: Retroviruses are used as genetic tools to isolate transcriptionally active chromosomal regions. The retroviruses have a promoterless protein coding sequence located in U3 or U5. The retroviruses may be used to infect cells under conditions which permit selection for instances when the retrovirus integrates in close proximity to and under the control of a cellular promoter. The promoter and its associated gene then may be identified and isolated. In this manner, the retroviruses function as promoter-traps. Related methods and products including vectors, kits and assays provided.
    Type: Grant
    Filed: May 14, 1990
    Date of Patent: November 15, 1994
    Assignee: Massachusetts Institute of Technology
    Inventors: H. Earl Ruley, Harold von Melchner