Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.

Abstract: This invention encompasses novel methods of preparing sulfinamides and sulfoxides, particularly stereomerically pure sulfinamides and sulfoxides. The invention further encompasses novel compounds from which sulfinamides and sulfoxides can be prepared.

Abstract: One aspect of the present invention relates to optically pure (S)-amlodipine malate. Another aspect of the present invention relates to (rac)-amlodipine malate. In a preferred embodiment, the compound is optically pure (S)-amlodipine L-malate. Another aspect of the present invention relates to a pharmaceutical composition comprising optically pure (S)-amlodipine malate. Another aspect of the present invention relates to a method of preparing optically pure (S)-amlodipine malate, comprising admixing optically pure (S)-amlodipine with malic acid. Another aspect of the present invention relates to the various polymorphic and solvated forms of optically pure (S)-amlodipine malate. In another prefered embodiment the invention relates to polymorphic and solvated forms A-G. The present invention also relates to a method of preparing optically pure (S)-amlodipine malate, comprising combining a salt of optically pure (S)-amlodipine with a malate salt to give optically pure (S)-amlodipine malate.

Abstract: One aspect of the present invention relates to optically pure (S)-amlodipine malate. Another aspect of the present invention relates to (rac)-amlodipine malate. In a preferred embodiment, the compound is optically pure (S)-amlodipine L-malate. Another aspect of the present invention relates to a pharmaceutical composition comprising optically pure (S)-amlodipine malate. Another aspect of the present invention relates to a method of preparing optically pure (S)-amlodipine malate, comprising admixing optically pure (S)-amlodipine with malic acid. Another aspect of the present invention relates to the various polymorphic and solvated forms of optically pure (S)-amlodipine malate. In another prefered embodiment the invention relates to polymorphic and solvated forms A-G. The present invention also relates to a method of preparing optically pure (S)-amlodipine malate, comprising combining a salt of optically pure (S)-amlodipine with a malate salt to give optically pure (S)-amlodipine malate.

Abstract: The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,N?-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 or greater than 0.75:1.0.

Abstract: A harvesting of fruit from trees utilizing a harvesting machine which continuously advances along the row is explained. The harvesting machine utilizes a canopy penetration, fruit engagement and pressure severing method of mechanical harvesting. A plurality of arm members are held by an arm housing in either a single vertically disposed row or in a plurality of vertically disposed rows. During a harvesting procedure the arm housing undergoes a series of motions including rearward and forward on the harvesting machine as well as outward and inward therefrom. These motions may be controlled in an endless number of combinations to produce a desired harvesting action. One such harvesting action involves isolating to eliminate influence of the forward motion of the harvesting machine from the arm members during an extension motion and a retraction motion into and out of the canopy of the tree so that the arm members may enter the canopy with minimal resistance.

Abstract: Processes for preparing compounds having the general formula: ##STR1## wherein R.sup.1a is protected carboxy, carboxy, hydroxymethyl, protected hydroxymethyl, or methyl are disclosed. Processes of the invention begin with a starting material of the general formula IV ##STR2## wherein R.sup.1 and R.sup.2 are as defined in the specification.

Abstract: A coupling assembly is provided which allows for a dual pressure release during impaction of an obstruction during insertion of a picking arm into a canopy of a fruit tree. A first yielding occurs when a predetermined first level of resistance is encountered. If the obstruction is cleared and the resistance pressure falls below the first level of resistance the picking arm is returned to the normal deployed position. If the resistance level continues to climb and exceeds a predetermined second level of resistance the coupling assembly releases the arm to reduce the resistance pressure previously obtained while preventing any further resistance pressure from being generated. This acts to significantly reduce the opportunity that damage will occur to either the machinery or to the fruit tree. The possibility of multiple picking members is explained.

Abstract: Processes for preparing compounds having the general formula: ##STR1## wherein R.sup.1a is protected carboxy, carboxy, hydroxymethyl, protected hydroxymethyl, or methyl are disclosed. Processes of the invention begin with a starting material of the general formula II ##STR2## and elaborate the product by reductive amination of an aldehyde of formula IVa ##STR3## with .alpha.,.alpha.-diphenyl-4-piperidinemethanol.

Abstract: The mechanical harvesting of a citrus crop using a plurality of vertically spaced extending picking arms is disclosed. The means to construct mechanical devices capable of producing various picking patterns are explained with examples given. Specifically detailed is the use of a single power transference to power movement of multiple components which cooperate to provide a desired action. Picking members capable of securely engaging individual citrus fruits are provided which will slidably engage, without damaging, branches of the tree. Multiple picking members on each picking arm are explained. Release means incorporated into the picking members for releasing branches are presented. A method of preventing damage during insertion of the picking arms is provided which provides two levels of impacting protection. Both stationary and continuous advance of the harvester during usage are explained.