Patents by Inventor Harold Zappe

Harold Zappe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20190070251
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: April 28, 2017
    Publication date: March 7, 2019
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • CONJUGATES OF A CHOLINESTERASE MOIETY AND A POLYMER
    Publication number: 20180207286
    Abstract: Conjugates of a cholinesterase moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.
    Type: Application
    Filed: January 12, 2018
    Publication date: July 26, 2018
    Inventors: Mary J. Bossard, Harold Zappe, Seoju Lee, Lal Ajitha Ratnapala Fernando
  • CONJUGATES OF AN IL-2 MOIETY AND A POLYMER
    Publication number: 20180085468
    Abstract: Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the non-peptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.
    Type: Application
    Filed: December 7, 2017
    Publication date: March 29, 2018
    Inventors: Mary J. Bossard, Cherie F. Ali, Xiaofeng Liu, Deborah H. Charych, Harold Zappe, Yujun Wang, Jicai Huang
  • Polymer conjugates of therapeutic peptides
    Patent number: 9682153
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 20, 2017
    Assignee: Nektar Therapeutics
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • Von willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
    Patent number: 9493544
    Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: November 15, 2016
    Assignees: Nektar Therapeutics, Baxalta Incorporated, Baxalta GmbH
    Inventors: Mary J. Bossard, Gayle Stephenson, Zhihao Fang, Harold Zappe, Stacy Mitchell, Ping Zhang, Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann, Katalin Varadi, Herbert Gritsch
  • Polymer-based compositions and conjugates of HIV entry inhibitors
    Patent number: 9446139
    Abstract: Provided herein are water-soluble polymer conjugates and polymer-based compositions of HIV entry inhibitors. Also provided are methods for synthesizing and administering such conjugates and compositions.
    Type: Grant
    Filed: March 15, 2005
    Date of Patent: September 20, 2016
    Assignee: Nektar Therapeutics
    Inventors: Michael D. Bentley, Xuan Zhao, Harold Zappe
  • Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation)
    Patent number: 9274122
    Abstract: The invention relates to the development of in vitro assay systems that force the release of a water-soluble polymer, such as polyethylene glycol (PEG) and polysialic acid (PSA), from proteins modified with a reversibly-linked water-soluble polymer. The invention includes methods for analyzing the release of the water-soluble polymer and measuring regained protein activity. The invention further includes methods appropriate for the quality control of proteins modified with releasable water-soluble polymers, including polymers like PEG and PSA.
    Type: Grant
    Filed: October 20, 2009
    Date of Patent: March 1, 2016
    Assignees: BAXALTA INCORPORATED, BAXALTA GMBH, NEKTAR THERAPEUTICS
    Inventors: Katalin Varadi, Gerald Schrenk, Hanspeter Rottensteiner, Peter Turecek, Alfred Weber, Heinz Anderle, Sean M. Culbertson, Zhihao Fang, Harold Zappe, Ping Zhang, Mary J. Bossard
  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20160022828
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: March 20, 2015
    Publication date: January 28, 2016
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • Conjugates of an IL-2 Moiety and a Polymer
    Publication number: 20140328791
    Abstract: Conjugates of an IL-2 moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.
    Type: Application
    Filed: November 11, 2011
    Publication date: November 6, 2014
    Inventors: Mary J. Bossard, Cherie F. Ali, Xiaofeng Liu, Deborah H. Charych, Harold Zappe, Yujun Wang, Jicai Huang
  • Polymer conjugates of nesiritide peptides
    Patent number: 8449872
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of peptide not attached to the water-soluble oligomer.
    Type: Grant
    Filed: September 17, 2009
    Date of Patent: May 28, 2013
    Assignee: Nektar Therapeutics
    Inventors: Harold Zappe, Mary J. Bossard
  • VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE
    Publication number: 20130012442
    Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicants: NEKTAR THERAPEUTICS, Baxter Healthcare SA, Baxter International Inc.
    Inventors: Mary J. Bossard, Gayle Stephenson, Zhihao Fang, Harold Zappe, Stacy Mitchell, Ping Zhang, Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann, Katalin Varadi, Herbert Gritsch
  • Von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
    Patent number: 8349800
    Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: January 8, 2013
    Assignees: Nektar Therapeutics, Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Mary J. Bossard, Gayle Stephenson, Zhihao Fang, Harold Zappe, Stacy Mitchell, Ping Zhang, Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann, Katalin Varadi, Herbert Gritsch
  • Von Willebrand Factor- and Factor VIII-Polymer Conjugates Having a Releasable Linkage
    Publication number: 20120142594
    Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
    Type: Application
    Filed: February 10, 2012
    Publication date: June 7, 2012
    Applicants: Baxter International Inc., NEKTAR THERAPEUTICS
    Inventors: Mary J. Bossard, Gayle Stephenson, Zhihao Fang, Harold Zappe, Stacy Mitchell, Ping Zhang, Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann, Katalin Varadi, Herbert Gritsch
  • von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage
    Patent number: 8133865
    Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: March 13, 2012
    Assignees: Nektar Therapeutics, Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Mary J. Bossard, Gayle Stephenson, Zhihao Fang, Harold Zappe, Stacy Mitchell, Ping Zhang, Friedrich Scheiflinger, Peter Turecek, Juergen Siekmann, Katalin Varadi, Herbert Gritsch
  • POLYMER CONJUGATES OF KISS1 PEPTIDES
    Publication number: 20110171160
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 14, 2011
    Applicant: Nektar Therapeutics
    Inventors: Elizabeth Louise Minamitani, Harold Zappe, Mary J. Bossard, Steven O. Roczniak, Xiaofeng Liu
  • POLYMER CONJUGATES OF ZICONOTIDE PEPTIDES
    Publication number: 20110171163
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 14, 2011
    Applicant: Nektar Therapeutics
    Inventors: Dawei Sheng, Harold Zappe, C. Simone Jude-Fishburn, Steven O. Roczniak, Mary J. Bossard
  • POLYMER CONJUGATES OF THYMOSIN ALPHA 1 PEPTIDES
    Publication number: 20110171162
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 14, 2011
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Harold Zappe, Mary J. Bossard
  • POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES
    Publication number: 20110166063
    Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 7, 2011
    Applicant: Nektar Therapeutics
    Inventors: Mary J. Bossard, Steven O. Roczniak, Harold Zappe, Yujun Wang, Ping Zhang, Dawei Sheng, C. Simone Jude-Fishburn, Elizabeth Louise Minamitani, Xiaofeng Liu, Haim Moskowitz, Dennis G. Fry, Cherie F. Ali, Christine Taylor Brew
  • POLYMER CONJUGATES OF NESIRITIDE PEPTIDES
    Publication number: 20110165111
    Abstract: The invention provides nesiritide that is chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of nesiritide not attached to the water-soluble oligomer.
    Type: Application
    Filed: September 17, 2009
    Publication date: July 7, 2011
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Harold Zappe, Mary J. Bossard
  • Conjugates of a Cholinesterase Moiety and a Polymer
    Publication number: 20110135623
    Abstract: Conjugates of a cholinesterase moiety and one or more nonpeptidic, water soluble polymers are provided. Typically, the nonpeptidic, water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.
    Type: Application
    Filed: May 15, 2009
    Publication date: June 9, 2011
    Applicant: NEKTAR THERAPEUTICS
    Inventors: Mary J. Bossard, Harold Zappe, Seoju Lee, Lal Ajitha Ratnapala Fernando