Abstract: The present disclosure relates to an injector device having a container and a plunger. The plunger is movable into the container to dispense medicament during operation of the injector device. The injector device also has a switch arranged to interact with a structural element of the plunger to detect movement of the plunger during operation of the injector device.

Abstract: Disclosed is a method of facilitating operation of an entity. The method may include receiving, using a communication device, an event data corresponding to an event associated with the entity. Further, the method may include receiving, using the communication device, user data from two or more mobile devices associated with two or more users. Yet further, the method may include identifying, using a processing device, one or more users based on each of the event data and the user data. Further, the method may include transmitting, using the communication device, one or more notifications to the one or more mobile devices based on the identifying. Moreover, the method may include receiving, using the communication device, an indication of a donation from the one or more mobile devices. The donation may be associated with the event.

Abstract: The present invention relates to polymeric nanoparticles comprising bortezomib and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.

Abstract: The present invention relates to polymeric nanoparticles comprising a pharmaceutical combination, pharmaceutical compositions comprising the same, and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.

Abstract: The present invention relates to the field of nanotechnology, in particular, to the production of biodegradable polymeric nanoparticles. The present invention provides a biodegradable polymeric nanoparticle made up of a block copolymer and a process for producing the same. The nanoparticles are produced without the use of any emulsifiers and have a size ranging from 30-120 nm. The methods of controlling the drug loading capacity are disclosed along with the process of producing entity-loaded nanoparticles. Compositions comprising the nanoparticles and their use in therapeutics, diagnostics and theranostics are also disclosed.

Abstract: An article is provided for use with an apparatus for heating smokable material to volatilize at least one component of the smokable material. The article has a carrier and smokable material arranged on the carrier. The smokable material has a first layer of smokable material and a second layer of smokable material. The first layer of smokable material is located between the carrier and the second layer of smokable material. The smokable material of the first layer of smokable material has a form or chemical composition that differs from the form or chemical composition, respectively, of the smokable material of the second layer of smokable material.

Abstract: A cartridge is provided for use with an apparatus for heating smokable material. The cartridge has a housing defining a chamber and a pouch containing smokable material. The pouch is located within the chamber. At least part of the pouch is made of porous material for permitting aerosol or volatilized material generated within the pouch to pass out of the pouch from within the pouch. There is also provided a pouch having a first wall and a second wall. The pouch contains smokable material between the first wall and the second wall. A method of manufacturing a pouch is also disclosed in which the first wall is attached to the second wall with smokable material between the first wall and second wall.

Abstract: An article is provided for use with an apparatus for heating smokable material. The article has a body of porous aerosol containment material. An annular first body of smokable material is located around the body of porous aerosol containment material. There is also provided apparatus for heating smokable material having a first heater extending along an axis and a second heater spaced from and at least partially surrounding the first heater. A method of manufacturing an article for use with an apparatus is also disclosed in which an assembly having porous aerosol containment material on a first layer of smokable material is provided and rolled so the first layer of smokable material becomes an annular body of smokable material located around the porous aerosol containment material.

Abstract: Provided is a telephoto lens including a first lens group, the first lens group including: a first lens element including: an object side lens surface facing an object side; and an image side lens surface facing an image side; and a prism configured to bend an optical path within the first lens element, wherein the first lens element and the prism are formed as a single body, wherein an inclined surface of the prism is provided between the object side lens surface and the image side lens surface, and wherein the following relationship is satisfied: 1.3?L1/Li, where L1 corresponds to a length of an optical path within the first lens element along an optical axis of the first lens elements and Li corresponds to a length of an optical path between an optical element provided closest to an image plane and the image plane along the optical axis.

Abstract: The present invention relates to the field of nanotechnology, in particular, to the production of biodegradable polymeric nanoparticles. The present invention provides a biodegradable polymeric nanoparticle made up of a block copolymer and a process for producing the same. The nanoparticles are produced without the use of any emulsifiers and have a size ranging from 30-120 nm. The methods of controlling the drug loading capacity are disclosed along with the process of producing entity-loaded nanoparticles. Compositions comprising the nanoparticles and their use in therapeutics, diagnostics and theranostics are also disclosed.

Abstract: A hydrogenated diamond-like coating (“H-DLC”) for metallic substrates provides improved reliability. The H-DLC is relatively soft and elastic. Unlike hard and/or inelastic coatings in the prior art, the present coatings do not exhibit a loss of adhesion (delamination). A bonding layer may be used between the metallic substrate and the H-DLC. H-DLC coatings can, for example, be used in bearings and gears to reduce the occurrence of micropits and, ultimately, product failure.

Abstract: A novel insecticidal chitinase protein from fern Tectaria sp., a process for preparation of the insecticidal protein and nucleic acid sequence encoding for said insecticidal protein and its application for insect control purposes.

Abstract: A method for making a pitting resistant carbon coating that includes a hydrogenated diamond-like coating (“H-DLC”). The H-DLC is relatively soft and elastic. Unlike hard and/or inelastic coatings in the prior art, the present coatings do not exhibit a loss of adhesion (delamination). A bonding layer may be deposited on a metallic substrate and the deposited H-DLC on the bonding layer.

Abstract: Described herein is a cartridge for use with apparatus for heating smokable material to volatilize at least one component of the smokable material. The cartridge comprises a housing defining a chamber, and a heating device located in the chamber. The heating device is arranged to heat smokable material to volatilize at least one component of the smokable material. The heating device comprises a heating element and smokable material arranged on the heating element. Also disclosed is apparatus for heating smokable material to volatilize at least one component of the smokable material. The apparatus comprises an assembly having an interface, and the cartridge, wherein the cartridge is for co-operating with the interface of the assembly.

Abstract: Described herein is apparatus for heating smokable material to volatilize at least one component of the smokable material. The apparatus comprises an electrical power source having positive and negative terminals, a voltage regulator, and a controller for controlling the supply of electrical power to a heating element in use. One of the positive and negative terminals is electrically connected to the controller via the voltage regulator. The other of the positive and negative terminals is electrically connected to the controller by an electrically-conductive path that bypasses the voltage regulator.

Abstract: Described herein is a heating device for use with apparatus for heating smokable material to volatilize at least one component of the smokable material. The heating device comprises a heating element, and smokable material bonded to the heating element. The heating element comprises a layer of electrically-conductive material, a first layer of polyimide, and a second layer of polyimide. The layer of electrically-conductive material is located between the first and second layers of polyimide. Also described are cartridges comprising the heating device, apparatus comprising the heating device and methods of manufacturing the heating device.

Abstract: A grounding element is provided. The grounding element includes a first portion including a first metal; a second portion including a second metal other than the first metal; and a fastening portion configured to receive a fastener to attach the grounding element to a body. The grounding element may be welded to a body of a vehicle and used to ground a vehicle electrical system.

Abstract: A hydrogenated diamond-like coating (“H-DLC”) for metallic substrates provides improved reliability. The H-DLC is relatively soft and elastic. Unlike hard and/or inelastic coatings in the prior art, the present coatings do not exhibit a loss of adhesion (delamination). A bonding layer may be used between the metallic substrate and the H-DLC. H-DLC coatings can, for example, be used in bearings and gears to reduce the occurrence of micropits and, ultimately, product failure.

Abstract: Nucleic acid sequence encoding Allium fistulosum leaf agglutinin (AFAL) is disclosed. The invention provides Allium fistulosum leaf agglutinin (AFAL) recombinant protein, its encoding nucleotides, primers and the process of preparation thereof, said recombinant protein is useful for insect control and haemagglutination activity. AFAL is found more toxic to sap sucking insect pest Aphis gossypii (cotton aphid) and Bemisia tabaci (whiteflies) as compared to known Allium sativum leaf agglutinin. AFAL can be used in the development of transgenic plants for resistance against sap sucking and chewing pests.

Abstract: Provided is a telephoto lens including a first lens group, the first lens group including: a first lens element including: an object side lens surface facing an object side; and an image side lens surface facing an image side; and a prism configured to bend an optical path within the first lens element, wherein the first lens element and the prism are formed as a single body, wherein an inclined surface of the prism is provided between the object side lens surface and the image side lens surface, and wherein the following relationship is satisfied: 1.3?L1/Li, where L1 corresponds to a length of an optical path within the first lens element along an optical axis of the first lens elements and Li corresponds to a length of an optical path between an optical element provided closest to an image plane and the image plane along the optical axis.