Patents by Inventor Harpreet Kaur
Harpreet Kaur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240051947Abstract: The present application includes an enantiomerically pure compound of Formula (R)-I or a salt and/or solvate thereof. Also included are compositions of the enantiomerically pure compound of Formula (R)-I as well as methods of using the compound of Formula (R)-I or composition thereof for treating, for example, disease, disorder or condition that benefits from psychotherapy. The present application also includes a composition comprising a non-racemic mixture a compound of Formula (R)-I, or a salt and/or solvate thereof, and (S)-I, or a salt and/or solvate thereof: wherein (R)-I, or a salt and/or solvate thereof, is present in the composition in a greater amount by enantiomeric equivalents, relative to (S)-I, or a salt and/or solvate thereof and uses thereof. Further included are process preparing a compound of Formula (R)-I or (S)-I.Type: ApplicationFiled: October 16, 2023Publication date: February 15, 2024Applicant: Pharmala Biotech Inc.Inventors: Harpreet Kaur, Tao Xin
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Publication number: 20230404916Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.Type: ApplicationFiled: August 8, 2023Publication date: December 21, 2023Applicant: AMNEAL COMPLEX PRODUCTS RESEARCH LLCInventors: Kanji Meghpara, Jaydeep Vagashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
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Publication number: 20230338337Abstract: The invention provides biomarkers to predict effective treatment of cancer using an MDM2 antagonist. Identifying one or more of these biomarkers in a cancer patient allows a determination to be made whether the patient's cancer is likely to be successfully treated using an MDM2 antagonist. Accordingly, the invention relates generally to a companion diagnostic for MDM2 antagonist therapy. The biomarkers are: (i) BAP1; and/or (ii) CDKN2A; and/or (iii) one, two, three, four, five, six, seven, eight, nine, ten or more of: CXCL10, CXCL11, RSAD2, MX1, BATF2, IF144L, IFITM1, ISG15, CMPK2, IF127, CD74, IFIH1, CCRL2, IF144, HERC6, ISG20, IFIT3, HLA-C, OAS1, IF135, IRF9, EPSTI1, USP18, BST2, CSF1, C1S, DHX58, TRIM14, OASL, IRF7, LGALS3BP, DDX60, LAP3, LAMP3, PARP12, PARP9, SP110, PLSCR1, WARS, STAT1, IRF3, IRF5, MSC, JUN, SPI1, IRF1, COMMD3-BMI1, STAT2, RUNX3, SREBF1, FLI1 and BRCA1.Type: ApplicationFiled: December 23, 2020Publication date: October 26, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Nicola FERRARI, Harpreet Kaur SAINI, Jong Sook AHN
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Publication number: 20230313313Abstract: The invention provides SKP2 as a biomarker to predict effective treatment of cancer using an MDM2 antagonist. Identifying this biomarker in a cancer patient allows a determination to be made whether the patient's cancer is likely to be successfully treated using an MDM2 antagonist. Accordingly, the invention relates generally to a companion diagnostic for MDM2 antagonist therapy. The SKP2 biomarker may be measured directly, or indirectly by detection of a molecule that is functionally upstream or downstream of SKP2 and the level of which correlates with the level of the SKP2 biomarker, such as the detection of one or more SKP2 substrates.Type: ApplicationFiled: August 27, 2021Publication date: October 5, 2023Applicant: OTSUKA PHARMACEUTICAL CO., LTD.Inventors: Nicola FERRARI, Harpreet Kaur SAINI, Jong Sook AHN
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Patent number: 11746436Abstract: A coloured single crystal CVD synthetic diamond material comprising: a plurality of layers, wherein the plurality of layers includes at least two sets of layers which differ in terms of their defect composition and colour, wherein defect type, defect concentration, and layer thickness for each of the at least two sets of layers is such that if the coloured single crystal CVD diamond material is fabricated into a round brilliant cut diamond comprising a table and a culet, and having a table to culet depth greater than 1 mm, the round brilliant cut diamond comprises a uniform colour as viewed by naked human eye under standard ambient viewing conditions in at least a direction through the table to the culet.Type: GrantFiled: September 13, 2013Date of Patent: September 5, 2023Assignee: Element Six Technologies LimitedInventors: Harpreet Kaur Dhillon, Ian Friel, Daniel James Twitchen, Sarah Louise Geoghegan, Helen Jennifer Gallon, Neil Perkins, Philip Maurice Martineau
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Publication number: 20230271908Abstract: Disclosed herein are methods, processes and compositions for preparing a compound of formula 8: (8), and formula 18: (18). The methods and processes comprise performing a first allylic oxidation, a protection reaction, a second allylic oxidation, a reduction reaction, performing an acid-catalyzed coupling reaction, a methylation reaction and a deprotection reaction. Disclosed herein are methods, processes and compositions for enantioselectively preparing compounds of formulae 8 and 18. Also disclosed herein are compositions comprising compounds of formulae 8, 18 and/or intermediates and/or starting material thereof.Type: ApplicationFiled: September 23, 2021Publication date: August 31, 2023Applicant: Tetra Bio-Pharma Inc.Inventors: Harpreet Kaur, Xuejun Liu, Prabin Nepal, Subakar Paramanantham, Monika Garg, Zemin Li, Andy Tjeng, Moises Rodriguez, Laura Jong, Azam Mirzahossein, Ofer Yifrach-Stav, Erin Bassett, Randy Ringuette, Charles Campbell, Melanie Kelly
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Publication number: 20230263709Abstract: The present invention provides a compound which is a polyether phosphate ester and which does not comprise an alkylene oxide residue. The invention also provides a composition which comprises: i) a polyether phosphate ester; ii) a mono-alcohol phosphate ester; and iii) a polyether which comprises at least two terminal C6 to C36 hydrocarbyl groups. Further aspects of the invention include an emulsion, a personal care formulation, uses and methods comprising the compound or composition of the invention.Type: ApplicationFiled: July 13, 2021Publication date: August 24, 2023Applicant: Croda, Inc.Inventors: Erik Gunderman, Paul Joseph Saporito, Abel Goncalves Pereira, Marni Dexter, Harpreet Kaur
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Publication number: 20230201159Abstract: The present application includes a composition comprising a non-racemic mixture a compound of Formula (R)-I, or a salt and/or solvate thereof, and (S)-I, or a salt and/or solvate thereof: wherein (R)-I, or a salt and/or solvate thereof, is present in the composition in a greater amount by enantiomeric equivalents, relative to (S)-I, or a salt and/or solvate thereof. Also included are methods of using these compositions for treating, for example, a psychiatric disorder. The compounds of Formula (R)-I and (S)-I include the enantiomers of 3,4-methylenedioxymethamphetamine (MDMA) and N-methyl-1,3-benzodioxolylbutanamine (MBDB). Also included in the present application is a method for treating various diseases, disorders or conditions using a therapeutically effective amount of (R)-MDMA, or a pharmaceutically acceptable salt and/or solvate thereof.Type: ApplicationFiled: March 6, 2023Publication date: June 29, 2023Inventors: Nicholas Kadysh, Leonard Howell, Harpreet Kaur
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Patent number: 11615061Abstract: A workload of a database may be evaluated to provide a database migration recommendation. A request for a recommendation to migrate a database to a new host may be received. An evaluation of the workload of a client application of the database at a current host may be performed. The migration recommendation may be returned based on the evaluation of the workload of the client application of the database. In some embodiments, the migration recommendation may trigger an automated migration of the database to the new host.Type: GrantFiled: August 3, 2018Date of Patent: March 28, 2023Assignee: Amazon Technologies, Inc.Inventors: Sameer Malik, Danial George Neault, Rostislav Babocichin, Harpreet Kaur Chawla, Knievel Co, Ilia Gilderman, Ramya Kaushik, Edward Paul Murray, Siva Raghupathy, Venu Reddy, Samujjwal Roy, Eran Schitzer, Michael D. Soo, Arun Kumar Thiagarajan, John Winford, Chen Zhang
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Publication number: 20230084240Abstract: The disclosed technology is generally directed to carbon capture and storage. In one example of the technology, a first neural network is trained with synthetic data that is associated with seismic images of synthetic simulated subsurfaces. The first neural network extracts features from multiple resolutions of the seismic images of the synthetic simulated subsurfaces. The ground truth includes synthetic labels that indicate probabilities of potential carbon dioxide leakage pathways of the synthetic simulated subsurfaces. A seismic image of a first subsurface is received. At least the trained first neutral network is used to generate output labels that indicate probabilities of potential leakage pathways of carbon dioxide storage of the first subsurface.Type: ApplicationFiled: September 10, 2021Publication date: March 16, 2023Inventors: Qie Zhang, Harpreet Kaur
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Patent number: 11396715Abstract: A single crystal diamond material comprising: neutral nitrogen-vacancy defects (NV0); negatively charged nitrogen-vacancy defects (NV?); and single substitutional nitrogen defects (Ns) which transfer their charge to the neutral nitrogen-vacancy defects (NV0) to convert them into the negatively charged nitrogen-vacancy defects (NV), characterized in that the single crystal diamond material has a magnetometry figure of merit (FOM) of at least 2, wherein the magnetometry figure of merit is defined by (I) where R is a ratio of concentrations of negatively charged nitrogen-vacancy defects to neutral nitrogen-vacancy defects ([NV?]/[NV0]), [NV?] is the concentration of negatively charged nitrogen-vacancy defects measured in parts-per-million (ppm) atoms of the single crystal diamond material, [NV0] is a concentration of neutral nitrogen-vacancy defects measured in parts-per-million (ppm) atoms of the single crystal diamond material, and T2? is a decoherence time of the NV? defects, where T2? is T2* for DC magnetomeType: GrantFiled: December 6, 2016Date of Patent: July 26, 2022Assignees: Element Six Technologies Limited, Element Six Technologies US CorporationInventors: Wilbur Lew, Gregory Bruce, Andrew Mark Edmonds, Matthew Lee Markham, Alastair Douglas Stacey, Harpreet Kaur Dhillon
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Publication number: 20220218604Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.Type: ApplicationFiled: March 24, 2022Publication date: July 14, 2022Applicant: AMNEAL COMPLEX PRODUCTS RESEARCH LLCInventors: Kanji Meghpara, Jaydeep Vaghashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
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Patent number: 11318091Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.Type: GrantFiled: April 19, 2021Date of Patent: May 3, 2022Assignee: Amneal Complex Products Research LLCInventors: Kanji Meghpara, Jaydeep Vaghashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
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Publication number: 20210262329Abstract: A method and apparatus for generating a high-resolution seismic image, including extracting a reflectivity distribution from a geological model; utilizing the reflectivity distribution to label features of the model; generating forward-modeled data from the model; migrating the forward-modeled data to create a migrated image; and training a deep neural network with the labeled synthetic geological model and the migrated image to create a reflectivity prediction network. A method and apparatus includes: selecting a first subset of the field data; applying a low-pass filter to the first subset to generate a first filtered dataset; migrating the first filtered dataset to create a first migrated image; applying a high-pass filter to the first subset to generate a second filtered dataset; migrating the second filtered dataset to create a second migrated image; and training a deep neural network to predict a target distribution of high-frequency signal.Type: ApplicationFiled: December 17, 2020Publication date: August 26, 2021Inventors: Harpreet Kaur, Junzhe Sun, Mehdi Aharchaou
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Publication number: 20210236421Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.Type: ApplicationFiled: April 19, 2021Publication date: August 5, 2021Applicant: AMNEAL COMPLEX PRODUCTS RESEARCH LLCInventors: Kanji Meghpara, Jaydeep Vaghashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
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Patent number: 11060204Abstract: There is described a single crystal CVD diamond material comprising three orthogonal dimensions of at least 2 mm; one or more regions of low optical birefringence, indicative of low strain, such that in a sample of the single crystal CVD diamond material having a thickness in a range 0.5 mm to 1.0 mm and an area of greater than 1.3 mm×1.3 mm and measured using a pixel size of area in a range 1×1 ?m2 to 20×20 ?m2, a maximum value of ?n[average] does not exceed 1.5×10?4 for the one or more regions of low optical birefringence, where ?n[average] is an average value of a difference between refractive index for light polarised parallel to slow and fast axes averaged over the sample thickness; one or more regions of high optical birefringence, indicative of high strain, such that in said sample of the single crystal CVD diamond material and measured using said pixel size, ?n[average] is greater than 1.5×10?4 and less than 3×10?3; and is wherein every 1.3 mm×1.Type: GrantFiled: November 30, 2017Date of Patent: July 13, 2021Assignee: Element Six Technologies LimitedInventors: Daniel James Twitchen, Harpreet Kaur Dhillon, Rizwan Uddin Ahmad Khan
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Patent number: 11007145Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.Type: GrantFiled: October 7, 2020Date of Patent: May 18, 2021Assignee: KASHIV SPECIALTY PHARMACEUTICALS, LLCInventors: Kanji Meghpara, Jaydeep Vaghashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
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Publication number: 20210115590Abstract: There is described a single crystal CVD diamond material comprising three orthogonal dimensions of at least 2 mm; one or more regions of low optical birefringence, indicative of low strain, such that in a sample of the single crystal CVD diamond material having a thickness in a range 0.5 mm to 1.0 mm and an area of greater than 1.3 mm×1.3 mm and measured using a pixel size of area in a range 1×1 ?m2 to 20×20 ?m2, a maximum value of ?n[average] does not exceed 1.5×10?4 for the one or more regions of low optical birefringence, where ?n[average] is an average value of a difference between refractive index for light polarised parallel to slow and fast axes averaged over the sample thickness; one or more regions of high optical birefringence, indicative of high strain, such that in said sample of the single crystal CVD diamond material and measured using said pixel size, ?n[average] is greater than 1.5×10?4 and less than 3×10?3; and is wherein every 1.3 mm×1.Type: ApplicationFiled: November 30, 2017Publication date: April 22, 2021Applicant: ELEMENT SIX TECHNOLOGIES LIMITEDInventors: DANIEL JAMES TWITCHEN, HARPREET KAUR DHILLON, RIZWAN UDDIN AHMAD KHAN
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Publication number: 20210108333Abstract: A single crystal CVD diamond material is disclosed, the material comprising a total nitrogen concentration of at least 3 ppm as measured by secondary ion mass spectrometry (SIMS); and a low optical birefringence such that in a sample of the single crystal CVD diamond material having an area of at least 1.3 mm×1.3 mm, and measured using a pixel size of area in a range 1×1 ?m2 to 20×20 ?m2, a maximum value of ?n[average] does not exceed 1.5×10?4, where ?n[average] is an average value of a difference between refractive index for light polarised parallel to slow and fast axes averaged over the sample thickness. A method of making the material is also disclosed.Type: ApplicationFiled: November 30, 2017Publication date: April 15, 2021Applicant: ELEMENT SIX TECHNOLOGIES LIMITEDInventors: MATTHEW LEE MARKHAM, ANDREW MARK EDMONDS, HARPREET KAUR DHILLON, DAVID WILLIAM HARDEMAN
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Patent number: 10960001Abstract: The presently disclosed subject matter provides a solid, immediate release, pharmaceutical multi-particulate dosage form containing at least one population of Opioid Particulates comprising one or more opioids; at least one population of Naloxone Particulates; and a population of Triggering Particulates. Each population of particulates is designed for a specific function to accomplish the desired combination of abuse deterrence and overdose protection.Type: GrantFiled: January 12, 2018Date of Patent: March 30, 2021Assignee: KASHIV BIOSCIENCES, LLCInventors: Navnit H. Shah, Wantanee Phuapradit, Dipen Desai, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Chanchal Patel, Roshan V. Tiwari, Atsawin Thongsukmak