Patents by Inventor Harri Harma

Harri Harma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10914679
    Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: February 9, 2021
    Assignee: Kemira Oyj
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Paul Mundill
  • Patent number: 10241047
    Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.
    Type: Grant
    Filed: September 27, 2017
    Date of Patent: March 26, 2019
    Assignee: Kemira Oyj
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
  • Patent number: 10156558
    Abstract: A method for determining samples including one or more organic polymers by mixing them with lanthanide(III) ions and detecting the signal of the lanthanide(III) ion chelated with the organic polymer.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: December 18, 2018
    Assignee: KEMIRA OYJ
    Inventor: Harri Harma
  • Publication number: 20180284022
    Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.
    Type: Application
    Filed: March 21, 2018
    Publication date: October 4, 2018
    Applicant: Kemira Oyj
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Paul Mundill
  • Patent number: 9958389
    Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionized group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: May 1, 2018
    Assignee: KEMIRA OYJ
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Paul Mundill
  • Publication number: 20180017494
    Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.
    Type: Application
    Filed: September 27, 2017
    Publication date: January 18, 2018
    Applicant: Kemira Oyj
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
  • Patent number: 9816927
    Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.
    Type: Grant
    Filed: November 18, 2014
    Date of Patent: November 14, 2017
    Assignee: KEMIRA OYJ
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
  • Publication number: 20160290924
    Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.
    Type: Application
    Filed: November 18, 2014
    Publication date: October 6, 2016
    Applicant: Kemira Oyj
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
  • Publication number: 20160290923
    Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.
    Type: Application
    Filed: November 18, 2014
    Publication date: October 6, 2016
    Applicant: KEMIRA OYJ
    Inventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Paul Mundill
  • Publication number: 20160274079
    Abstract: A method for determining samples including one or more organic polymers by mixing them with lanthanide(III) ions and detecting the signal of the lanthanide(III) ion chelated with the organic polymer.
    Type: Application
    Filed: September 24, 2014
    Publication date: September 22, 2016
    Applicant: Aqsens Oy
    Inventor: Harri HARMA
  • Publication number: 20150094234
    Abstract: This invention relates to a method for characterizing and/or determining a samples, particularly in the aid of lanthanide(III) ions and ligands including an aromatic structure and 2-5 chelating heteroatoms. The invention relates also to an array for characterizing and/or determining a samples utilizing the properties of lanthanide(III) chelates.
    Type: Application
    Filed: April 23, 2013
    Publication date: April 2, 2015
    Inventors: Harri Härmä, Sari Pihlasalo
  • Patent number: 8956877
    Abstract: A separation-free assay including a binding partner, a binding partner labeled with a directly luminescent label, and a nonspecifically binding label able to affect the signal of the unbound labeled binding partner, in which a signal of the binding partner label or the signal of the nonspecific binding label is measured in a binding event, and where at least one of the binding partners is a mobile binding partner.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: February 17, 2015
    Assignee: Aqsens Oy
    Inventor: Harri Härmä
  • Publication number: 20130295683
    Abstract: A device for holding a sample for optical fingerprinting analysis comprises a carrier, and a distribution of non-specific interacting surfaces extending across said carrier. At least one fluidic channel allows a fluid sample to flow through at least a part of said carrier to get in touch with one or more of said non-specific interacting surfaces. One or more optical windows adjacent to said non-specific interacting surfaces enable optical analysis of results of said sample getting in touch with said non-specific interacting surfaces at multiple locations of the carrier.
    Type: Application
    Filed: November 7, 2011
    Publication date: November 7, 2013
    Applicant: AQSENS OY
    Inventors: Paul Mundill, Harri Härmä, Pekka Hänninen
  • Publication number: 20120046201
    Abstract: Characterizing and/or determining a sample employs an array of at least two of different interacting surfaces, at least one of which comprises a non-specific interacting material non-specifically interacting said sample, at least one labelling reactant, and/or combination of the sample and at least one labelling reactant. The sample and at least one labelling reactant is introduced to interact with said interacting surfaces of said array, wherein said labelling reactant is adapted to change at least one electromagnetically readable property of at least one interacting surface of said array.
    Type: Application
    Filed: April 30, 2010
    Publication date: February 23, 2012
    Applicant: AQSENS OY
    Inventors: Pekka Hänninen, Harri Härmä
  • Patent number: 7569355
    Abstract: A homogeneous bioassay including a first group labelled with an energy donor and a second group labelled with an energy acceptor, where the donor is a luminescent lanthanide label capable of up-converting a lower-energy excitation to a higher-energy emission, where the acceptor is either a luminescent or a non-luminescent label, and where the increase or decrease, respectively, in energy transfer from the donor to the acceptor resulting from shortening or lengthening of the distance between the labels is measured. The assay is performed in a biological fluid which absorbs radiation in the wavelength range 300 to 600 nm, the measurement is carried out at a wavelength >570 nm, and the donor label, which is excitable at wavelength longer than its emission wavelength, is excited in the wavelength window in which the biological fluid does not essentially absorb the excitation radiation.
    Type: Grant
    Filed: June 9, 2005
    Date of Patent: August 4, 2009
    Inventors: Tero Soukka, Harri Härmä, Timo Lövgren
  • Publication number: 20090017477
    Abstract: This invention relates to a method comprising the steps of a) contacting a sample containing a sample substance and a solid phase comprising a signal element, and optionally a substance containing a signal element, i.e. a signal element substance; wherein at least one of said sample substance, said solid phase, and said signal element substance comprises a signal element; wherein the surface of the solid phase contains no specific binding partners; and wherein the solid phase is capable of binding said sample substance nonspecifically, preferably through adsorption, to said solid phase, and b) detecting a signal change resulted from binding of said sample substance and/or signal element substance to said solid phase, and/or change in distance from said sample substance and/or said signal element substance to said solid phase.
    Type: Application
    Filed: June 30, 2008
    Publication date: January 15, 2009
    Inventors: Harri HARMA, Tero Soukka
  • Publication number: 20090017466
    Abstract: This invention relates to a separation-free assay method employing a binding partner label and a nonspecifically binding label, wherein a signal from said binding partner label or said nonspecifically binding label is measured in a binding event, said method comprising the use of a) two or more binding partners, and a directly luminescent binding partner label adsorbed and/or covalently coupled to at least one of said binding partners; and b) said nonspecifically binding label, wherein i) said nonspecifically binding label is able to affect the signal of said binding partner label, or ii) said binding partner label is able to affect the signal of said nonspecifically binding label; and wherein at least one of said binding partners is a mobile binding partner and at least one other of said binding partners is a labeled ligand.
    Type: Application
    Filed: August 6, 2008
    Publication date: January 15, 2009
    Inventor: Harri HARMA
  • Publication number: 20050272084
    Abstract: This invention concerns a luminescence energy transfer based homogeneous bioassay comprising a first group labelled with an energy donor and a second group labelled with an energy acceptor, wherein the donor is a luminescent lanthanide label, said label being able to up-convert a lower-energy excitation to a higher-energy emission, the acceptor is either a luminescent or a non-luminescent label, and the increase or decrease, respectively, in energy transfer from the donor to the acceptor resulting from shortening or lengthening, respectively, of the distance between said labels is measured. According to the invention, the assay is performed in a biological fluid which absorbs radiation in the wavelength range 300 to 600 nm, the measurement is carried out at a wavelength>570 nm, and the donor label, which is excitable at wavelength longer than its emission wavelength, is excited in the wavelength window in which the biological fluid does not essentially absorb the excitation radiation.
    Type: Application
    Filed: June 9, 2005
    Publication date: December 8, 2005
    Inventors: Tero Soukka, Harri Harma, Timo Lovgren