Patents by Inventor Harri Harma
Harri Harma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10914679Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.Type: GrantFiled: March 21, 2018Date of Patent: February 9, 2021Assignee: Kemira OyjInventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Paul Mundill
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Patent number: 10241047Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.Type: GrantFiled: September 27, 2017Date of Patent: March 26, 2019Assignee: Kemira OyjInventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
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Patent number: 10156558Abstract: A method for determining samples including one or more organic polymers by mixing them with lanthanide(III) ions and detecting the signal of the lanthanide(III) ion chelated with the organic polymer.Type: GrantFiled: September 24, 2014Date of Patent: December 18, 2018Assignee: KEMIRA OYJInventor: Harri Harma
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Publication number: 20180284022Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.Type: ApplicationFiled: March 21, 2018Publication date: October 4, 2018Applicant: Kemira OyjInventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Paul Mundill
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Patent number: 9958389Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionized group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.Type: GrantFiled: November 18, 2014Date of Patent: May 1, 2018Assignee: KEMIRA OYJInventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Paul Mundill
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Publication number: 20180017494Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.Type: ApplicationFiled: September 27, 2017Publication date: January 18, 2018Applicant: Kemira OyjInventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
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Patent number: 9816927Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.Type: GrantFiled: November 18, 2014Date of Patent: November 14, 2017Assignee: KEMIRA OYJInventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
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Publication number: 20160290924Abstract: The invention relates to a method for analysing a sample comprising at least a first and a second scale inhibitor, which scale inhibitors are synthetic organic compounds comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample interact with a reagent comprising lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement. The total concentration of the first and the second scale inhibitor is determined by using the detected sample signal, and the concentration of the first scale inhibitor in the sample is determined. The concentration of the second scale inhibitor is determined mathematically by using the obtained results for the total concentration and for the first scale inhibitor concentration.Type: ApplicationFiled: November 18, 2014Publication date: October 6, 2016Applicant: Kemira OyjInventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Mirva Lehmusto, Satu Tiittanen, Pave Väisänen, Joonas Siivonen, Paul Mundill
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Publication number: 20160290923Abstract: The invention relates to a method for determining a scale inhibitor concentration in a sample comprising at least a first scale inhibitor, which is a synthetic organic compound comprising at least one ionised group. The method comprises optionally diluting and/or purifying the sample, and allowing the sample to interact with a reagent comprising a lanthanide(III) ion. The sample is excited at a first excitation wavelength and a sample signal deriving from the lanthanide(III) ion is detected at a signal wavelength by using time-resolved luminescence measurement, and the concentration of the at least first scale inhibitor in the sample is determined by using the detected sample signal.Type: ApplicationFiled: November 18, 2014Publication date: October 6, 2016Applicant: KEMIRA OYJInventors: Vesa Nuutinen, Susanna Toivonen, James Johnstone, Harri Härmä, Paul Mundill
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Publication number: 20160274079Abstract: A method for determining samples including one or more organic polymers by mixing them with lanthanide(III) ions and detecting the signal of the lanthanide(III) ion chelated with the organic polymer.Type: ApplicationFiled: September 24, 2014Publication date: September 22, 2016Applicant: Aqsens OyInventor: Harri HARMA
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Publication number: 20150094234Abstract: This invention relates to a method for characterizing and/or determining a samples, particularly in the aid of lanthanide(III) ions and ligands including an aromatic structure and 2-5 chelating heteroatoms. The invention relates also to an array for characterizing and/or determining a samples utilizing the properties of lanthanide(III) chelates.Type: ApplicationFiled: April 23, 2013Publication date: April 2, 2015Inventors: Harri Härmä, Sari Pihlasalo
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Patent number: 8956877Abstract: A separation-free assay including a binding partner, a binding partner labeled with a directly luminescent label, and a nonspecifically binding label able to affect the signal of the unbound labeled binding partner, in which a signal of the binding partner label or the signal of the nonspecific binding label is measured in a binding event, and where at least one of the binding partners is a mobile binding partner.Type: GrantFiled: August 6, 2008Date of Patent: February 17, 2015Assignee: Aqsens OyInventor: Harri Härmä
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Publication number: 20130295683Abstract: A device for holding a sample for optical fingerprinting analysis comprises a carrier, and a distribution of non-specific interacting surfaces extending across said carrier. At least one fluidic channel allows a fluid sample to flow through at least a part of said carrier to get in touch with one or more of said non-specific interacting surfaces. One or more optical windows adjacent to said non-specific interacting surfaces enable optical analysis of results of said sample getting in touch with said non-specific interacting surfaces at multiple locations of the carrier.Type: ApplicationFiled: November 7, 2011Publication date: November 7, 2013Applicant: AQSENS OYInventors: Paul Mundill, Harri Härmä, Pekka Hänninen
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Publication number: 20120046201Abstract: Characterizing and/or determining a sample employs an array of at least two of different interacting surfaces, at least one of which comprises a non-specific interacting material non-specifically interacting said sample, at least one labelling reactant, and/or combination of the sample and at least one labelling reactant. The sample and at least one labelling reactant is introduced to interact with said interacting surfaces of said array, wherein said labelling reactant is adapted to change at least one electromagnetically readable property of at least one interacting surface of said array.Type: ApplicationFiled: April 30, 2010Publication date: February 23, 2012Applicant: AQSENS OYInventors: Pekka Hänninen, Harri Härmä
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Patent number: 7569355Abstract: A homogeneous bioassay including a first group labelled with an energy donor and a second group labelled with an energy acceptor, where the donor is a luminescent lanthanide label capable of up-converting a lower-energy excitation to a higher-energy emission, where the acceptor is either a luminescent or a non-luminescent label, and where the increase or decrease, respectively, in energy transfer from the donor to the acceptor resulting from shortening or lengthening of the distance between the labels is measured. The assay is performed in a biological fluid which absorbs radiation in the wavelength range 300 to 600 nm, the measurement is carried out at a wavelength >570 nm, and the donor label, which is excitable at wavelength longer than its emission wavelength, is excited in the wavelength window in which the biological fluid does not essentially absorb the excitation radiation.Type: GrantFiled: June 9, 2005Date of Patent: August 4, 2009Inventors: Tero Soukka, Harri Härmä, Timo Lövgren
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Publication number: 20090017477Abstract: This invention relates to a method comprising the steps of a) contacting a sample containing a sample substance and a solid phase comprising a signal element, and optionally a substance containing a signal element, i.e. a signal element substance; wherein at least one of said sample substance, said solid phase, and said signal element substance comprises a signal element; wherein the surface of the solid phase contains no specific binding partners; and wherein the solid phase is capable of binding said sample substance nonspecifically, preferably through adsorption, to said solid phase, and b) detecting a signal change resulted from binding of said sample substance and/or signal element substance to said solid phase, and/or change in distance from said sample substance and/or said signal element substance to said solid phase.Type: ApplicationFiled: June 30, 2008Publication date: January 15, 2009Inventors: Harri HARMA, Tero Soukka
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Publication number: 20090017466Abstract: This invention relates to a separation-free assay method employing a binding partner label and a nonspecifically binding label, wherein a signal from said binding partner label or said nonspecifically binding label is measured in a binding event, said method comprising the use of a) two or more binding partners, and a directly luminescent binding partner label adsorbed and/or covalently coupled to at least one of said binding partners; and b) said nonspecifically binding label, wherein i) said nonspecifically binding label is able to affect the signal of said binding partner label, or ii) said binding partner label is able to affect the signal of said nonspecifically binding label; and wherein at least one of said binding partners is a mobile binding partner and at least one other of said binding partners is a labeled ligand.Type: ApplicationFiled: August 6, 2008Publication date: January 15, 2009Inventor: Harri HARMA
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Publication number: 20050272084Abstract: This invention concerns a luminescence energy transfer based homogeneous bioassay comprising a first group labelled with an energy donor and a second group labelled with an energy acceptor, wherein the donor is a luminescent lanthanide label, said label being able to up-convert a lower-energy excitation to a higher-energy emission, the acceptor is either a luminescent or a non-luminescent label, and the increase or decrease, respectively, in energy transfer from the donor to the acceptor resulting from shortening or lengthening, respectively, of the distance between said labels is measured. According to the invention, the assay is performed in a biological fluid which absorbs radiation in the wavelength range 300 to 600 nm, the measurement is carried out at a wavelength>570 nm, and the donor label, which is excitable at wavelength longer than its emission wavelength, is excited in the wavelength window in which the biological fluid does not essentially absorb the excitation radiation.Type: ApplicationFiled: June 9, 2005Publication date: December 8, 2005Inventors: Tero Soukka, Harri Harma, Timo Lovgren