Patents by Inventor Harrie Vaessen

Harrie Vaessen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of isavuconazole or ravuconazole
    Patent number: 10590092
    Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: March 17, 2020
    Assignee: Basilea Pharmaceutica AG
    Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
  • PROCESS FOR THE MANUFACTURE OF ISAVUCONAZOLE OR RAVUCONAZOLE
    Publication number: 20190077771
    Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
    Type: Application
    Filed: September 11, 2017
    Publication date: March 14, 2019
    Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
  • Process for the manufacture of isavuconazole or ravuconazole
    Patent number: 9783508
    Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: October 10, 2017
    Assignee: Basilea Pharmaceutica AG
    Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser
  • PROCESS FOR THE MANUFACTURE OF ISAVUCONAZOLE OR RAVUCONAZOLE
    Publication number: 20150239852
    Abstract: The invention relates to a process for the manufacture of diastereomerically and enantiomerically enriched triazole compounds isavuconazole and ravuconazole, comprising a Reformatsky reaction between a ketone and a 2-halozincpropionate ester, followed by a resolution step, preferably an enzymatic resolution with an esterase enzyme.
    Type: Application
    Filed: July 31, 2013
    Publication date: August 27, 2015
    Inventors: Ruben Van Summeren, Harrie Vaessen, Daniel Mink, Mario Waser