Patents by Inventor Harrihar A. Pershadsingh

Harrihar A. Pershadsingh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,2-dithiolane derivatives
    Patent number: 6204288
    Abstract: This invention provides new thiazolindinedione derivatives and new arylacetic acid derivatives. These compounds are useful for the treatment of certain cardiovascular certain diseases, certain endocrine diseases, certain inflammatory diseases, certain neoplastic (malignant) and non-malignant proliferative diseases, certain neuro-psychiatric disorders, certain viral diseases, and diseases associated with these viral infections as discussed herein.
    Type: Grant
    Filed: February 3, 2000
    Date of Patent: March 20, 2001
    Assignee: The University of Mississippi
    Inventors: Harrihar A. Pershadsingh, Mitchell A. Avery
  • 1,2-Dithiolane derivatives
    Patent number: 6127394
    Abstract: This invention provides new thiazolindinedione derivatives and new arylacetic acid derivatives. These compounds are useful for the treatment of certain cardiovascular certain diseases, certain endocrine diseases, certain inflammatory diseases, certain neoplastic (malignant) and non-malignant proliferative diseases, certain neuro-psychiatric disorders, certain viral diseases, and diseases associated with these viral infections as discussed herein.
    Type: Grant
    Filed: March 8, 1999
    Date of Patent: October 3, 2000
    Assignee: The University of Mississippi
    Inventors: Harrihar A. Pershadsingh, Mitchell A. Avery
  • Thiazolidine derivatives for the treatment of hypertension
    Patent number: 6110951
    Abstract: This invention relates to a second medical use of thiazolidine compounds having anti-diabetic properties. These compounds are also of use for the control of essential hypertension.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 29, 2000
    Inventors: Harrihar A. Pershadsingh, Theodore W. Kurtz
  • Flavonoid derivatives
    Patent number: 6087385
    Abstract: The present invention provides thiazolidinediones which are useful as antiproliferative, antiinflammatory and antiinfective agents. These compounds are useful for the treatment of certain endocrine diseases including diabetes, certain malignant and non-malignant proliferative diseases including prostate cancer, breast cancer, psoriasis, and acne, certain cardiovascular disorders including hypertension and occlusive vascular diseases.
    Type: Grant
    Filed: November 3, 1999
    Date of Patent: July 11, 2000
    Assignee: University of Mississippi
    Inventors: Harrihar A. Pershadsingh, Mitchell A. Avery
  • Flavonoid derivatives
    Patent number: 6028088
    Abstract: The present invention provides thiazolidinediones which are useful as antiproliferative, antiinflammatory and antiinfective agents. These compounds are useful for the treatment of certain endocrine diseases including diabetes, certain malignant and non-malignant proliferative diseases including prostate cancer, breast cancer, psoriasis, and acne, certain cardiovascular disorders including hypertension and occlusive vascular diseases.
    Type: Grant
    Filed: October 30, 1998
    Date of Patent: February 22, 2000
    Assignee: The University of Mississippi
    Inventors: Harrihar A. Pershadsingh, Mitchell A. Avery
  • Methods for treating proliferative and inflammatory skin diseases
    Patent number: 5981586
    Abstract: Methods of inhibiting the proliferation of keratinocytes and inflammation of the skin comprising administering to a human in need of treatment an effective amount of a compound that modifies the activity of the peroxisome proliferator activated receptor gamma (PPAR.gamma.) in skin; and pharmaceutically acceptable salts and solvates thereof.
    Type: Grant
    Filed: May 22, 1998
    Date of Patent: November 9, 1999
    Inventor: Harrihar A. Pershadsingh
  • Calcium antagonists for treatment of vascular restenosis
    Patent number: 5866595
    Abstract: According to the present invention, compounds selected from the thiozole class of organic molecules are employed as antagonists for receptor-operated ion channels (ROICs) useful in the treatment of a variety of disease states in which ROICs are implicated. ROICs of particular interest are receptor-operated calcium channels (ROCCs). Compounds of particular interest with respect to the subject invention are compounds of the thiazolidinedione class of organic molecules, more particularly ciglitazone. Disease states in which particular utility is expected include vasculoproliferative diseases such as atherosclerosis, restenosis following angioplasty, and other conditions in which PDGF is known to play a role. The utility of the present invention with respect to further studies on the operation of ROICs and ROCCs and their role in disease will be apparent to those of skill in the art.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: February 2, 1999
    Assignee: The Regents of The University of California
    Inventors: Harrihar A. Pershadsingh, Theodore W. Kurtz
  • Thiazolidine derivatives for the treatment of hypertension
    Patent number: 5843970
    Abstract: This invention relates to a second medical use of thiazolidine compounds having anti-diabetic properties. These compounds are also of use for the control of essential hypertension.
    Type: Grant
    Filed: July 8, 1991
    Date of Patent: December 1, 1998
    Inventors: Harrihar A. Pershadsingh, Theodore W. Kurtz
  • Thiazolidine derivatives for the treatment of psoriasis
    Patent number: 5824694
    Abstract: A new medical use for certain thiazolidine derivatives is disclosed. Specifically, treatment of hyperproliferative epithelial cell conditions, such as psoriasis, by administration of thiazolidinediones or 5'-aryl substituted thiazolidine derivatives is described. Appropriate chemical structures, synthetic reactions, formulations, routes of administration and dosages are included.
    Type: Grant
    Filed: April 18, 1996
    Date of Patent: October 20, 1998
    Assignee: Bethesda Pharmaceuticals, Inc.
    Inventors: Theodore W. Kurtz, Harrihar A. Pershadsingh
  • Thiazolidine derivatives for the treatment of psoriasis
    Patent number: 5594015
    Abstract: A new medical use for certain thiazolidine derivatives is disclosed. Specifically, treatment of hyperproliferative epithelial cell conditions, such as psoriasis, by administration of thiazolidinediones or 5'-aryl substituted thiazolidine derivatives is described. Appropriate chemical structures, synthetic reactions, formulations, routes of administration and dosages are included.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: January 14, 1997
    Assignee: Regents of the University of California
    Inventors: Theodore W. Kurtz, Harrihar A. Pershadsingh
  • Thiazolidine derivatives for the treatment of hypertension
    Patent number: 5053420
    Abstract: This invention relates to a second medical use of thiazolidine compounds having anti-diabetic properties. These compounds are also of use for the control of essential hypertension.
    Type: Grant
    Filed: October 13, 1989
    Date of Patent: October 1, 1991
    Inventors: Harrihar A. Pershadsingh, Theodore W. Kurtz