Patents by Inventor Harris A. Lewin

Harris A. Lewin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7803919
    Abstract: A quantitative trait locus (QTL) affecting milk fat and protein concentration was localized to a 4cM confidence interval on chromosome 6 centered on the microsatellite BM143. The genes and sequence variation in this region were characterized, and common haplotypes spanning five polymorphic sites in the genes IBSP, SPP1, PKD2, and ABCG2 for two sires heterozygous for this QTL were localized. Expression of SPP1 and ABCG2 in the bovine mammary gland increased from parturition through lactation. SPP1 was sequenced, and all the coding exons of ABCG2 and PKD2 were sequenced for these two sires. The single nucleotide change capable of encoding a substitution of tyrosine-581 to serine (Y581S) in the ABCG2 transporter was the only polymorphism corresponding to the segregation status of all three heterozygous and 15 homozygous sires for the QTL in the Israeli and US Holstein populations.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: September 28, 2010
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Eyal Seroussi, Harris A. Lewin, Mark R. Band, Miri Cohen-Zinder, James K. Drackley, Denis M. Larkin, Juan J. Loor, Micha Ron, Moshe Shani, Joel Ira Weller
  • Patent number: 7638275
    Abstract: Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals.
    Type: Grant
    Filed: May 27, 2004
    Date of Patent: December 29, 2009
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Harris A. Lewin, Zonglin Liu, Sandra Rodriguez-Zas, Robin E. Everts
  • Publication number: 20070118912
    Abstract: A quantitative trait locus (QTL) affecting milk fat and protein concentration was localized to a 4cM confidence interval on chromosome 6 centered on the microsatellite BM143. The genes and sequence variation in this region were characterized, and common haplotypes spanning five polymorphic sites in the genes IBSP, SPP1, PKD2, and ABCG2 for two sires heterozygous for this QTL were localized. Expression of SPP1 and ABCG2 in the bovine mammary gland increased from parturition through lactation. SPP1 was sequenced, and all the coding exons of ABCG2 and PKD2 were sequenced for these two sires. The single nucleotide change capable of encoding a substitution of tyrosine-581 to serine (Y581S) in the ABCG2 transporter was the only polymorphism corresponding to the segregation status of all three heterozygous and 15 homozygous sires for the QTL in the Israeli and US Holstein populations.
    Type: Application
    Filed: June 28, 2006
    Publication date: May 24, 2007
    Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE AGRICULTURAL RESEARCH ORGANIZATION OF ISRAEL
    Inventors: Eyal Seroussi, Harris Lewin, Mark Band, Miri Cohen-Zinder, James Drackley, Denis Larkin, Juan Loor, Micha Ron, Moshe Shani, Joel Weller
  • Publication number: 20050137805
    Abstract: Genetically elite ungulate mammals are identified on the basis of gene expression profiles from biological samples such as liver and blood. Methods and compositions are presented to select genetically elite animals with a desired phenotype such as high milk production for breeding to improve production levels. A method to select an animal with a specific phenotype, e.g. milk production and health traits, includes creating a Gene Expression Index for a specific phenotype and using the index to identify candidate animals for breeding by comparing the index to gene expression profiles of the animals.
    Type: Application
    Filed: May 27, 2004
    Publication date: June 23, 2005
    Inventors: Harris Lewin, Zonglin Liu, Sandra Rodriguez-Zas, Robin Everts
  • Patent number: 5582987
    Abstract: The present disclosure provides a method for evaluating resistance of an animal of the genus Bos to persistent lymphocytosis. The method includes the steps of (a) obtaining a sample of DNA from the animal that includes a DRB3 gene exon 2; (b) identifying nucleotides of the DRB3 gene exon 2; and (c) determining whether the nucleotides contain codons that encode a glutamic acid at position 70 and an arginine at position 71, a valine at position 75, an aspartic acid at position 76, a threonine at position 77, and a tyrosine at position 78 of the DRB3 gene product, the presence of which codons indicates susceptibility to persistent lymphocytosis. Kits containing primers that hybridize to nucleotide positions 70 and 71 or 75-78 of the DRB3 gene exon 2 are also provided.
    Type: Grant
    Filed: September 6, 1994
    Date of Patent: December 10, 1996
    Assignee: The Board of Trustees of The University of Illinois
    Inventors: Harris A. Lewin, Michiel J. T. van Eijk