Patents by Inventor Harris B. Renfroe

Harris B. Renfroe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aroyl substituted dihydro-1,4-thiazines
    Patent number: 4622322
    Abstract: Compounds of the formula ##STR1## wherein Ar is pyridyl or phenyl substituted by halogen, halo-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, or carboxy-C.sub.1 -C.sub.4 -alkyl, n is zero, one or two, R.sub.1 is hydrogen, C.sub.1 -C.sub.4 -alkyl, heterocyclyl-C.sub.2 -C.sub.4 -alkyl, amino-C.sub.2 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkylamino-C.sub.2 -C.sub.4 -alkyl, di-C.sub.1 -C.sub.4 -alkylamino-C.sub.2 -C.sub.4 -alkylor C.sub.1 -C.sub.4 -alkanoyl, and R.sub.2 is hydrogen, carboxy-C.sub.1 -C.sub.4 -alkyl, or C.sub.1 -C.sub.4 -alkoxy-carbonyl-C.sub.1 -C.sub.4 -alkyl are disclosed as well as their preparation, pharmaceutical compositions containing the same and the use thereof as antirheumatic agents.
    Type: Grant
    Filed: June 29, 1984
    Date of Patent: November 11, 1986
    Assignee: Ciba-Geigy Corporation
    Inventor: Harris B. Renfroe
  • N-Substituted-2-(1-imidazolyl)indoles
    Patent number: 4539410
    Abstract: Various 1-carboxylic acid substituted-2-(1-imidazolyl)indoles and functional derivatives thereof are highly specific thromboxane synthetase inhibitors. Synthesis of, pharmaceutical compositions thereof, methods of treatment utilizing such compounds and intermediates for their synthesis are included.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: September 3, 1985
    Assignee: Ciba-Geigy Corporation
    Inventor: Harris B. Renfroe
  • 3-Substituted-2-(heteroaryl) indoles
    Patent number: 4511573
    Abstract: Disclosed as thromboxane synthetase inhibitors are the compounds of formula ##STR1## wherein R.sub.1 represents hydrogen or lower alkyl;Ar represents 3-pyridyl or 1-imidazolyl, each unsubstituted or substituted by lower alkyl, carboxy, lower alkoxycarbonyl or carbamoyl;R.sub.2 and R.sub.3 independently represent hydrogen, lower alkyl, halogen, trifluoromethyl, hydroxy, lower alkoxy, carboxy lower alkyl, lower alkoxycarbonyl lower alkyl, carboxy, lower alkoxycarbonyl, or lower alkyl-(thio, sulfinyl or sulfonyl), or R.sub.2 and R.sub.
    Type: Grant
    Filed: May 17, 1983
    Date of Patent: April 16, 1985
    Assignee: Ciba-Geigy Corporation
    Inventor: Harris B. Renfroe
  • N-Substituted-2-pyridylindoles
    Patent number: 4478842
    Abstract: Various 1-carboxylic acid substituted-2-pyridylindoles and functional derivatives thereof are highly specific thromboxane synthetase inhibitors. Synthesis of, pharmaceutical compositions thereof, and methods of treatment utilizing such compounds are included.
    Type: Grant
    Filed: November 1, 1982
    Date of Patent: October 23, 1984
    Assignee: Ciba-Geigy Corporation
    Inventor: Harris B. Renfroe
  • N-Substituted-2-pyridylindoles
    Patent number: 4460777
    Abstract: Various 1-carboxylic acid substituted-2-pyridylindoles and functional derivatives thereof are highly specific thromboxane synthetase inhibitors. Synthesis of, pharmaceutical compositions thereof, and methods of treatment utilizing such compounds are included.
    Type: Grant
    Filed: September 17, 1982
    Date of Patent: July 17, 1984
    Assignee: Ciba-Geigy Corporation
    Inventor: Harris B. Renfroe
  • Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
    Patent number: 4436746
    Abstract: Various 1-carboxylic acid substituted-2-(1-imidazolyl)indoles and functional derivatives thereof are highly specific thromboxane synthetase inhibitors. Synthesis of, pharmaceutical compositions thereof, and methods of treatment utilizing such compounds are included.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: March 13, 1984
    Assignee: Ciba-Geigy Corporation
    Inventor: Harris B. Renfroe