Abstract: Pharmaceutical formulations and methods of manufacture of such formulations used in the treatment of microbial infections and cell proliferation conditions. The pharmaceutical formulations include anti-microbial and/or anti-cell proliferation agents which comprise a mastic extract product and essential oil, or a mastic isolated component, or synthetic equivalents thereof prepared as oral or topical formulations. Further, methods of treating microbial infections or cell proliferation conditions in a subject are provided wherein an oral or topical formulation of an anti-microbial agent or anti-cell proliferation agent is administered to a subject so as to treat infection or condition.