Abstract: Antisense oligonucleotides specific for the muscarinic type 2 acetylcholine receptor mRNA have been identified. Administration of these oligonucleotides to animals resulted in an increase in memory and learning. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.

Abstract: This invention includes a plurality of ambient sensors at least one human subject stimulator, at least one sensor adapted to detect the human subject response to the stimuli, and a controller programmed to receive information from the environmental or ambient sensors, to control the stimulators, and to record the human subject's response to the stimuli via the human response sensors. The invention can monitor and record, over a series of consecutive time periods, the human subject's vigilance, level of physical activity, and other physiological, physical, and chemical variables pertaining to the subject and his or her ambient environment. The invention can be used to prevent impairments in mental performance occurring due to fatigue or exposure to adverse environmental conditions or human subject condition.