Abstract: Many biologic processes taking place inside a living organism are unpredictable in time and space, and cannot be known exactly. These mechanisms and interactions among them are better modeled as physiological random processes, the statistics of which are fully described by joint characteristic functionals. The present invention provides methods for the estimation of joint characteristic functionals through imaging of multiple physiological random processes. This technology can be used to study complex diseases, such as tumors and viral infections, by imaging the biological processes involved with disease progression and response to treatment.

Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.

Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.

Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.

Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.

Abstract: The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

Abstract: The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

Abstract: The present invention provides autoradiography methods and systems for imaging via the detection of alpha particles, beta particles, or other charged particles. Embodiments of the methods and systems provide high-resolution 3D imaging of the distribution of a radioactive probe, such as a radiopharmaceutical, on a tissue sample. Embodiments of the present methods and systems provide imaging of tissue samples by reconstruction of a 3D distribution of a source of particles, such as a radiopharmaceutical. Embodiments of the methods and systems provide tomographic methods including microtomography, macrotomography, cryomicrotomography and cryomacrotomography.

Abstract: The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

Abstract: The present invention provides methods and systems for 3D imaging of in vivo and ex vivo tissues. The disclosed systems and methods employ an autoradiographic approach where particles emitted by a radioactive composition within the tissue are detected. Once detected, a 3D representation of the source of particles within the tissue is reconstructed for viewing and analysis.

Abstract: An X-ray detection device including a scintillator configured to convert gamma rays or X-rays into optical radiation, an optical image intensifier configured to intensify the optical radiation to generate intensified optical radiation, an optical coupling system configured to guide the intensified optical radiation, and a solid state detector configured to detect the intensified optical radiation to generate an interaction image representing an X-ray energy emission and to perform photon counting based on data of the interaction image.

Abstract: A gamma-ray or X-ray detection device including a scintillator configured to convert gamma rays or X-rays into optical radiation, an optical image intensifier configured to intensify the optical radiation to generate intensified optical radiation, an optical coupling system configured to guide the intensified optical radiation, and a solid state detector configured to detect the intensified optical radiation to generate an interaction image representing a gamma-ray or X-ray energy emission.

Abstract: An imaging apparatus for simultaneously determining optical parameters of the eye comprising: a light source for illuminating at least a portion of the eye pupil; an illumination optical system for directing light rays emitted from the light source into the eye; a light receiving optical system for guiding the light rays reflected from the eye to a detector unit, wherein the detector unit detects an image intensity distribution from the light rays reflected from the eye; and an arithmetic unit for determining optical characteristics of the eye by parameter estimation is provided.

Abstract: An X-ray detection device including a scintillator configured to convert gamma rays or X-rays into optical radiation, an optical image intensifier configured to intensify the optical radiation to generate intensified optical radiation, an optical coupling system configured to guide the intensified optical radiation, and a solid state detector configured to detect the intensified optical radiation to generate an interaction image representing an X-ray energy emission and to perform photon counting based on data of the interaction image.

Abstract: A gamma-ray or X-ray detection device including a scintillator configured to convert gamma rays or X-rays into optical radiation, an optical image intensifier configured to intensify the optical radiation to generate intensified optical radiation, an optical coupling system configured to guide the intensified optical radiation, and a solid state detector configured to detect the intensified optical radiation to generate an interaction image representing a gamma-ray or X-ray energy emission.

Abstract: An imaging apparatus for simultaneously determining optical parameters of the eye comprising: a light source for illuminating at least a portion of the eye pupil; an illumination optical system for directing light rays emitted from the light source into the eye; a light receiving optical system for guiding the light rays reflected from the eye to a detector unit, wherein the detector unit detects an image intensity distribution from the light rays reflected from the eye; and an arithmetic unit for determining optical characteristics of the eye by parameter estimation is provided.

Abstract: A coded aperture is placed in proximity of a patient's body and a 2D coded image is acquired in conventional manner. The basic data-acquisition geometry is similar to that used in various coded-aperture systems. According to one aspect of the invention, additional coded images are acquired with different spacings between the aperture and the detector. Alternatively, additional coded images could be acquired with multiple movable apertures or by varying the location of the aperture relative to a patient. Another aspect of the invention resides in the recognition that presently available computer algorithms can process these multiple coded images in such a way as to estimate the integrals of the 3D object over a set of parallel cylindrical tubes extending through the volume of the target object. Such “tube integrals” can be thought of as the output of an ideal collimator where the sensitivity is confined to a tubular region of constant cross-section.

Abstract: A CdZnTe detector array with pixel electrodes indium-bump-bonded to a multiplexer readout circuit. The pixel size is selected so as to minimize the effect of hole trapping while ensuring that all interacting electrons deposit their energy in a designated central pixel. The readout is carried out either when a gamma-ray interaction event occurs or at time intervals likely to produce no more than one event of photon interaction at any given pixel. The readout signal for each pixel is compared to a corresponding threshold signal to identify clusters of adjacent pixels having an above-threshold signal. Then, a central pixel is designated for each cluster, the signals from a predetermined number of pixels in and/or neighboring the cluster are added to produce a cumulative signal, and the cumulative signal is assigned to the designated central pixel. The cumulative signals so produced and the positions of corresponding central pixels are then processed to generate an image of the gamma-ray emitting source.

Abstract: An improvement to phase-shifting interferometry that consists of the addition of a pupil mask with two parallel slits and a polarizer in the optical path of a conventional phase-shifting interferometer. The pupil-mask/polarizer combination is adapted to produce a linearly polarized wavefront of light reaching the sample surface at a predetermined angle of incidence, thereby producing a corresponding phase shift on reflection. The relative orientation of the mask and polarizer can be changed to take measurements with the polarizer parallel or perpendicular to the mask slits, in each case producing a phase shift on reflection related to the test sample's refractive index and extinction coefficient. Four phase-shifting measurements conducted at .pi./2 intervals for each polarization axis yield sufficient interferometric information to map n, k and the height profile of the sample surface.

Abstract: A hybrid gamma-ray semiconductor detector is used in combination with attenuating apertures of the kind used in emission computed tomography. The detector comprises a slab of semiconductor material partitioned into multiple cells individually connected to a multiplexer through indium-bump pressure welds for the sequential read-out of integrated pulses generated in each cell as a result of gamma-ray absorption events. The single output channel provided by the multiplexer permits the construction of semiconductor sensor cells approximately one millimeter in size for improved spatial resolution of the detector. The greater resolution of the detector makes it possible to narrow the distance between the image forming apertures and the detector's surface, thus minimizing overlapping of the gamma-ray radiation and the size of the overall apparatus.