Abstract: Symptoms of maladies originating in the same region of a brain can be treated with selective multifrequency stimulation. A first stimulation at a first frequency and a second stimulation at a second frequency can be generated by a signal generator. The first stimulation can be applied to a first location in the brain region to trigger an excitation period for a first set of neural elements in the brain region to treat at least one symptom of the malady. The second stimulation can be applied, after a time to ensure the first set of neural elements has entered a refractory period, to a second location in the brain region to trigger an excitation period for a second set of neural elements in the brain region to treat the at least one symptom and/or at least another symptom. The first set of neural elements is not excited by the second stimulation.