Patents by Inventor Harry B. Gray

Harry B. Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10840504
    Abstract: In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a Lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a Lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: November 17, 2020
    Assignee: California Institute of Technology
    Inventors: Simon C. Jones, Emmanuelle Despagnet-Ayoub, Brendon McNicholas, Harry B. Gray, Robert H. Grubbs, Danh Ngo
  • Patent number: 10406227
    Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 10, 2019
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Robert H. Chow, Mark S. Humayun, Harry B. Gray, Robert H. Grubbs, Dennis A. Dougherty, Mark E. Thompson, Lionel E. Cheruzel, Melanie A. Yen
  • Patent number: 10232043
    Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: March 19, 2019
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Melanie A. Yen, Dennis A. Dougherty, Robert H. Grubbs, Harry B. Gray, Robert H. Chow, Mark S. Humayun, Mark E. Thompson, Lionel E. Cheruzel
  • Publication number: 20180254478
    Abstract: In an aspect, a redox flow battery comprises a catholyte and an anolyte; wherein at least one of said catholyte and said anolyte is a metal-coordination complex, said metal-coordination complex comprising: (i) a metal; (ii) one or more first ligands coordinated with said metal atom, wherein each of said first ligands is independently a Lewis basic ligand; and one or more second ligands associated with said one or more first ligands, wherein each of said second ligands is independently a Lewis acid ligand; and a nonaqueous solvent, wherein said catholyte, said anolyte or both are dissolved in said nonaqueous solvent. One or more first ligands may be provided in a primary coordination sphere of said metal-coordination complex and one or more second ligands may be provided in a secondary coordination sphere of said metal-coordination complex.
    Type: Application
    Filed: February 23, 2018
    Publication date: September 6, 2018
    Inventors: Simon C. Jones, Emmanuelle Despagnet-Ayoub, Brendon McNicholas, Harry B. Gray, Robert H. Grubbs
  • Patent number: 10035806
    Abstract: The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 31, 2018
    Assignee: California Institute of Technology
    Inventors: Melanie A. Yen, Harry B. Gray, Robert H. Grubbs, Joshua Palmer
  • Publication number: 20180044804
    Abstract: Provided herein are processes and systems for oxidation of a hydrocarbon reactant to generate an oxidized hydrocarbon product; said process comprising: contacting a water oxidation electrocatalyst with said hydrocarbon reactant and water in the presence of a non-aqueous solvent; wherein an anodic bias is applied to said water oxidation electrocatalyst, thereby generating said oxidized hydrocarbon product; and wherein said water oxidation electrocatalyst comprises one or more transition metals other than Ru. Optionally, said water is provided in said non-aqueous solvent at a concentration less than or equal to 0.5 vol. %. Optionally, the magnitude of said anodic bias is selected to generate said oxidized hydrocarbon product characterized by selected product distribution.
    Type: Application
    Filed: August 11, 2017
    Publication date: February 15, 2018
    Inventors: Bryan M. HUNTER, Harry B. GRAY
  • Publication number: 20170189530
    Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.
    Type: Application
    Filed: August 18, 2016
    Publication date: July 6, 2017
    Inventors: Melanie A. Yen, Dennis A. Dougherty, Robert H. Grubbs, Harry B. Gray, Robert H. Chow, Mark S. Humayun, Mark Thompson, Oliver Shafaat, Erin Lamb
  • Patent number: 9636428
    Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Grant
    Filed: September 22, 2014
    Date of Patent: May 2, 2017
    Assignees: California Institute of Technology, Children's Hospital of Los Angeles
    Inventors: Carl M. Blumenfeld, Karn Sorasaenee, Harry B. Gray, Robert H. Grubbs
  • Publication number: 20170096434
    Abstract: The present invention is directed to derivatized corroles, methods of making and using the same as imaging and therapeutic agents. In certain embodiments, the corroles are compounds having a Structure (I-H) and (I-M): where R1, R2, R3, and R4 are independently —F or —N(H)—(CH2)m—Y, provided that at least one of R1, R2, R3, and R4 is —N(H)—(CH2)m—Y, and m and Y are described herein.
    Type: Application
    Filed: October 6, 2016
    Publication date: April 6, 2017
    Inventors: MELANIE A. YEN, HARRY B. GRAY, ROBERT H. GRUBBS, JOSHUA Palmer
  • Patent number: 9580451
    Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: February 28, 2017
    Assignees: California Institute of Technology, Children's Hospital of Los Angeles
    Inventors: Carl M. Blumenfeld, Harry B. Gray, Robert H. Grubbs, Karn Sorasaenee
  • Patent number: 9243015
    Abstract: Metallocorrole complexes of third row transition metals (see Formula I below) may be used as therapeutic agents, catalysts, components of oxygen detectors, and components of light emitting diodes. In particular, metallocorrole complexes of third row transition metals may be used as improved photosenitizers in photodynamic therapy; as improved catalysts in aziridination, epoxidation, and water splitting reactions; as improved in vivo imaging agents; and as improved components in the emissive layer of OLEDs. Due to their strongly sigma-donating nature, corroles are able to stabilize third row transition metals in high oxidation states. Third row transition metals are significantly more electropositive than their first and second row counterparts and may therefore act as improved catalysts.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: January 26, 2016
    Assignee: California Institute of Technology
    Inventors: Joshua H. Palmer, Zeev Gross, Harry B. Gray
  • Publication number: 20150368811
    Abstract: The invention is directed to mixed-metal nanocatalysts, particularly nano-dimensioned layered double-hydroxide nanostacks, methods of making nanocatalysts using laser ablation techniques, and the electrochemical devices comprising and using these nanocatalysts, for example in the electrochemical oxidation of water oxidation.
    Type: Application
    Filed: June 15, 2015
    Publication date: December 24, 2015
    Inventors: HARRY B. GRAY, JAY R. WINKLER, ASTRID M. MULLER, BRYAN M. HUNTER
  • Publication number: 20150328313
    Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.
    Type: Application
    Filed: December 18, 2013
    Publication date: November 19, 2015
    Inventors: Robert H. Chow, Mark S. Humayun, Harry B. Gray, Robert H. Grubbs, Dennis Dougherty, Mark Thompson, Oliver Shafaat, Erin Lamb
  • Publication number: 20150202331
    Abstract: The present disclosure is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Application
    Filed: September 22, 2014
    Publication date: July 23, 2015
    Inventors: Carl M. Blumenfeld, Karn Sorasaenee, Harry B. Gray, Robert H. Grubbs
  • Publication number: 20150198552
    Abstract: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: April 16, 2014
    Publication date: July 16, 2015
    Applicant: OHMX Corporation
    Inventors: Michael J. Ahrens, Paul A. Bertin, Amanda Eckermann, Dimitra Georganopoulou, Harry B. Gray, Markus Franz Wunder
  • Publication number: 20150192538
    Abstract: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
    Type: Application
    Filed: January 9, 2015
    Publication date: July 9, 2015
    Applicant: OHMX CORPORATION
    Inventors: MICHAEL J. AHRENS, PAUL A. BERTIN, HARRY B. GRAY, THOMAS J. MEADE
  • Publication number: 20150141640
    Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Inventors: Carl M. Blumenfeld, Harry B. Gray, Robert H. Grubbs, Karn Sorasaenee
  • Patent number: 8968789
    Abstract: The present invention is directed to sulfonic esters of metal oxides including those of formulas I and II:
    Type: Grant
    Filed: February 12, 2014
    Date of Patent: March 3, 2015
    Assignees: California Institute of Technology, Children's Hospital of Los Angeles
    Inventors: Carl M. Blumenfeld, Harry B. Gray, Robert H. Grubbs, Karn Sorasaenee
  • Patent number: 8951400
    Abstract: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.
    Type: Grant
    Filed: July 20, 2011
    Date of Patent: February 10, 2015
    Assignee: OHMX Corporation
    Inventors: Michael Ahrens, Paul A. Bertin, Harry B. Gray, Thomas J. Meade
  • Publication number: 20140342383
    Abstract: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, ?, of an electron transfer process.
    Type: Application
    Filed: May 19, 2014
    Publication date: November 20, 2014
    Applicant: OHMX Corporation
    Inventors: Paul A. Bertin, Michael J. Ahrens, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder