Abstract: Heterodimerizing domains with orthogonal mutations that drive heterodimerization, in particular heterodimerizing antibody CH3 domains, heterodimeric polypeptides comprising such heterodimerizing domains, and antibody constructs comprising such heterodimeric polypeptides, are provided.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: A rotary impulse sealer includes a roller having a roller body and a plurality of seal bars extending radially outwardly from the roller and spaced apart around the roller body. At least one of the seal bars has a body and a selectively heatable heating element extending along at least a part of a length of the seal bar body. The roller is rotatable through a pre-heating pressure application region in which the at least one seal bar is adapted to apply pressure to a bond area of the bondable material, followed by a heating region in which the at least one seal bar is adapted to heat the bond area, wherein the at least one seal bar and tensioned belt are configured to sandwich the bondable material directly between the at least one seal bar and tensioned belt during the pre-heating pressure application region and the heating region.

Abstract: Disclosed herein are nucleic acid molecules, polypeptides, cells, vectors, and pharmaceutical compositions relating to miniaturized dystrophin. Methods of production and methods of therapeutic use of the miniaturized dystrophin are also disclosed.

Abstract: There is provided a method of manufacturing sachets. The method involves moving a web of semi-rigid material through a cutting station and simultaneously cutting a discrete cut in the web of semi-rigid material while the web of semi-rigid material continues to move through the cutting station. The method also includes sandwiching the web of semi-rigid material between a first flexible web of material and a second web of flexible material such that the first web of flexible material seals the discrete cuts in the semi-rigid web of material and the second web of flexible material forms a continuous elongate reservoir with the web of semi-rigid material. There is also provided an apparatus for cutting a web of material. The apparatus has a cutting roller and at least one cutting element protruding beyond the exterior surface of the roller, wherein the cutting element has a cutting profile that is at least partly a zigzag shape.

Abstract: Disclosed herein are nucleic acid molecules, polypeptides, cells, vectors, and pharmaceutical compositions relating to miniaturized dystrophin. Methods of production and methods of therapeutic use of the miniaturized dystrophin are also disclosed.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: A rotary impulse sealer for forming a series of discrete bonds in a bondable material. The rotary impulse sealer has a roller rotatable about an axis. The roller has a roller body and a plurality of seal bars extending radially outwardly from the roller and spaced apart around the roller body. At least one of the seal bars has a body and a selectively heatable heating element extending along at least a part of a length of the seal bar body. The roller is rotatable through a pre-heating pressure application region in which the at least one seal bar is adapted to apply pressure to a bond area of the bondable material, followed by a heating region in which the at least one seal bar is adapted to heat the bond area, the regions being stationary with respect to the rotation of the roller.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: There is provided a duplexer having first, second and third ports and adapted for connection between an antenna and uplink and downlink, respectively, in a full duplex communication system. The duplexer has first and second quarter wave transformers connected between the first and third and between the first and second ports, respectively. The duplexer has a balancing resistor connected between the third port and the output of the second transformer. The duplexer has a filter circuit connected between the output of the second transformer and the second port.

Abstract: A wireless communication system has a base station operative to communicate wirelessly with a plurality of customer devices. The base station has a circulator with a first port connected to one or more signal transmission devices, a second port that is connected to one or more antennas, and a third port that is connected to one or more signal reception devices. The circulator communicates transmission signals from the one or more signal transmission devices to the one or more antennas, and communicates received signals from the one or more antennas to the one or more signal reception devices. The plurality of customers devices have cancellation/separation duplexers or circulators.

Abstract: An apparatus for loading and unloading containers of various sizes onto and off of a roll-off vehicle comprises a top frame and at least one lift actuator operable to pivot the top frame away from a horizontal home position to rearwardly incline the top frame. The top frame includes a main portion, a head portion longitudinally displaceable relative to the main portion, a plurality of sheaves, a cable extending through the sheaves, and a hoist actuator operable to displace the head portion between a retracted position and an extended position. The cable has a fixed end coupled to the head portion and a free end for coupling to a container. The hoist actuator is operated while the top frame is away from the home position to displace the head portion toward the extended position to load a container onto the vehicle, and toward the retracted position to unload the container.

Abstract: An adapter for releasably attaching a cable end having an end fitting to a frame of a hoist apparatus at an attachment opening of the frame includes a pair of longitudinal arms connected by a transverse bridge, an attachment portion coupled to the pair of arms and spaced longitudinally from the bridge, and a gate member. The bridge has inner and outer faces connected by a side face, a longitudinal cable passageway through the inner and outer faces, and a cable insertion slot communicating with the cable passageway, wherein the insertion slot is open through the inner, outer, and side faces. The gate member is received by the insertion slot, and is selectively removable from the slot to permit transversely directed insertion of a portion of the cable end through the slot into the cable passageway such that the end fitting is opposed by the inner face of the bridge.

Abstract: An adapter for releasably attaching a cable end having an end fitting to a frame of a hoist apparatus at an attachment opening of the frame includes a pair of longitudinal arms connected by a transverse bridge, an attachment portion coupled to the pair of arms and spaced longitudinally from the bridge, and a gate member. The bridge has inner and outer faces connected by a side face, a longitudinal cable passageway through the inner and outer faces, and a cable insertion slot communicating with the cable passageway, wherein the insertion slot is open through the inner, outer, and side faces. The gate member is received by the insertion slot, and is selectively removable from the slot to permit transversely directed insertion of a portion of the cable end through the slot into the cable passageway such that the end fitting is opposed by the inner face of the bridge.

Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

Abstract: An apparatus, system and method are provided for measuring state properties without requiring an internal or proximate power supply. The apparatus provides a sensing device that is responsive to fluctuations in a state property that are encountered within the test zone. Due to the fluctuations experienced by the sensing device, a sensing signal is generated and transmitted to an optical device, such as an interferometer. The sensing signal's affect on the optical device produces an interference pattern that may be detected remotely and correlated to the fluctuation experienced by the sensing device.

Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.

Abstract: The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted ?-lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity and lowering plasma levels of sterols.