Abstract: Disclosed herein are nucleic acid molecules, polypeptides, cells, vectors, and pharmaceutical compositions relating to miniaturized dystrophin. Methods of production and methods of therapeutic use of the miniaturized dystrophin are also disclosed.

Abstract: Disclosed herein are nucleic acid molecules, polypeptides, cells, vectors, and pharmaceutical compositions relating to miniaturized dystrophin. Methods of production and methods of therapeutic use of the miniaturized dystrophin are also disclosed.

Abstract: Heterodimerizing domains with orthogonal mutations that drive heterodimerization, in particular heterodimerizing antibody CH3 domains, heterodimeric polypeptides comprising such heterodimerizing domains, and antibody constructs comprising such heterodimeric polypeptides, are provided.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: Disclosed herein are nucleic acid molecules, polypeptides, cells, vectors, and pharmaceutical compositions relating to miniaturized dystrophin. Methods of production and methods of therapeutic use of the miniaturized dystrophin are also disclosed.

Abstract: Disclosed herein are nucleic acid molecules, polypeptides, cells, vectors, and pharmaceutical compositions relating to miniaturized dystrophin. Methods of production and methods of therapeutic use of the miniaturized dystrophin are also disclosed.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: There is provided a duplexer having first, second and third ports and adapted for connection between an antenna and uplink and downlink, respectively, in a full duplex communication system. The duplexer has first and second quarter wave transformers connected between the first and third and between the first and second ports, respectively. The duplexer has a balancing resistor connected between the third port and the output of the second transformer. The duplexer has a filter circuit connected between the output of the second transformer and the second port.

Abstract: Disclosed herein are fusion proteins comprising: (a) a first polypeptide comprising Interleukin-2 (IL2); and (b) a second polypeptide, fused in frame to the first polypeptide, wherein the second polypeptide comprises an extracellular domain of Interleukin-2 Receptor alpha (IL2R?), wherein IL2 or IL2R? comprises at least one fewer glycosylation site compared to native IL2 or native IL2R?. Methods of production and methods of therapeutic use of the fusion proteins are also disclosed.

Abstract: An apparatus for loading and unloading containers of various lengths onto and off of a roll-off vehicle has a floating lockdown mechanism which moves relative to a front end of the top frame. The floating lockdown mechanism is movable away from the front end of the top frame to meet and releasably confine a front roller on a shorter container, such that the lockdown mechanism can be utilized without pulling the container all the way to the front end of the top frame.

Abstract: A hoisting frame apparatus for loading and unloading containers onto and off of a roll-off vehicle includes adjustable head and tail portions that are cooperatively actuated by a single actuation stroke to move relative to a main portion of the hoisting frame apparatus. The hoisting frame apparatus includes a linkage connecting the tail portion to the head portion such that displacement of the head portion by a hoist actuator relative to the main portion causes displacement of the tail portion relative to the main portion. The total longitudinal displacement of the tail portion may be shorter than the total longitudinal displacement of the head portion, and the linkage may be configured to release the connection between the head and tail portions when the tail portion reaches a travel limit to allow independent further longitudinal displacement of the head portion.

Abstract: A wireless communication system has a base station operative to communicate wirelessly with a plurality of customer devices. The base station has a circulator with a first port connected to one or more signal transmission devices, a second port that is connected to one or more antennas, and a third port that is connected to one or more signal reception devices. The circulator communicates transmission signals from the one or more signal transmission devices to the one or more antennas, and communicates received signals from the one or more antennas to the one or more signal reception devices. The plurality of customers devices have cancellation/separation duplexers or circulators.

Abstract: An apparatus for loading and unloading containers of various sizes onto and off of a roll-off vehicle comprises a top frame and at least one lift actuator operable to pivot the top frame away from a horizontal home position to rearwardly incline the top frame. The top frame includes a main portion, a head portion longitudinally displaceable relative to the main portion, a plurality of sheaves, a cable extending through the sheaves, and a hoist actuator operable to displace the head portion between a retracted position and an extended position. The cable has a fixed end coupled to the head portion and a free end for coupling to a container. The hoist actuator is operated while the top frame is away from the home position to displace the head portion toward the extended position to load a container onto the vehicle, and toward the retracted position to unload the container.

Abstract: An apparatus for loading and unloading containers of various sizes onto and off of a roll-off vehicle comprises a top frame and at least one lift actuator operable to pivot the top frame away from a horizontal home position to rearwardly incline the top frame. The top frame includes a main portion, a head portion longitudinally displaceable relative to the main portion, a plurality of sheaves, a cable extending through the sheaves, and a hoist actuator operable to displace the head portion between a retracted position and an extended position. The cable has a fixed end coupled to the head portion and a free end for coupling to a container. The hoist actuator is operated while the top frame is away from the home position to displace the head portion toward the extended position to load a container onto the vehicle, and toward the retracted position to unload the container.

Abstract: An adapter for releasably attaching a cable end having an end fitting to a frame of a hoist apparatus at an attachment opening of the frame includes a pair of longitudinal arms connected by a transverse bridge, an attachment portion coupled to the pair of arms and spaced longitudinally from the bridge, and a gate member. The bridge has inner and outer faces connected by a side face, a longitudinal cable passageway through the inner and outer faces, and a cable insertion slot communicating with the cable passageway, wherein the insertion slot is open through the inner, outer, and side faces. The gate member is received by the insertion slot, and is selectively removable from the slot to permit transversely directed insertion of a portion of the cable end through the slot into the cable passageway such that the end fitting is opposed by the inner face of the bridge.

Abstract: There is provided a duplexer having first, second and third ports and adapted for connection between an antenna and uplink and downlink, respectively, in a full duplex communication system. The duplexer has first and second quarter wave transformers connected between the first and third and between the first and second ports, respectively. The duplexer has a balancing resistor connected between the third port and the output of the second transformer. The duplexer has a filter circuit connected between the output of the second transformer and the second port.

Abstract: An adapter for releasably attaching a cable end having an end fitting to a frame of a hoist apparatus at an attachment opening of the frame includes a pair of longitudinal arms connected by a transverse bridge, an attachment portion coupled to the pair of arms and spaced longitudinally from the bridge, and a gate member. The bridge has inner and outer faces connected by a side face, a longitudinal cable passageway through the inner and outer faces, and a cable insertion slot communicating with the cable passageway, wherein the insertion slot is open through the inner, outer, and side faces. The gate member is received by the insertion slot, and is selectively removable from the slot to permit transversely directed insertion of a portion of the cable end through the slot into the cable passageway such that the end fitting is opposed by the inner face of the bridge.

Abstract: A fluid collection device comprising a body comprising a capsule interface, and a capsule configured to interface with the body via the capsule interface and configured to hold a sample receiving chip. The sample receiving chip comprises a substrate that receives an aliquot volume of a sample fluid, wherein the substrate is operatively shaped to receive the aliquot volume of sample fluid through capillary action, and a sample region of the substrate, sized such that the volume of the sample fluid is sufficient to operatively cover a portion of the sample region, whereupon energy properties of the sample fluid can be transduced to produce a sample fluid reading.