Patents by Inventor Harry Ferres
Harry Ferres has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 4673573Abstract: A fibrinolytically active protein conjugate comprising at least one optionally blocked fibrinolytic enzyme linked by way of a site other than the catalytic site responsible for fibrinolytic activity to at least one human protein.Processes from making the conjugates and pharmaceutical compositions containing them are also described.Type: GrantFiled: January 9, 1985Date of Patent: June 16, 1987Assignee: Beecham Group p.l.c.Inventors: Harry Ferres, Richard A. G. Smith, Andrew J. Garman
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Patent number: 4285960Abstract: A class of substituted aminoalkyl esters of methicillin have good oral absorption properties.Type: GrantFiled: September 14, 1978Date of Patent: August 25, 1981Assignee: Beecham Group LimitedInventor: Harry Ferres
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Patent number: 4215120Abstract: A class of esters of the penicillin, nafcillin have the general formula: ##STR1## wherein A is a C.sub.1 -C.sub.6 alkylene group substituted with one or two groups of formula --NR.sup.1 R.sup.2 and optionally further substituted with one or more methyl or ethyl groups, wherein R.sup.1 and R.sup.2 are the same or different and each is a C.sub.1 -C.sub.6 alkyl group or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a saturated 5- or 6- membered heterocyclic ring. Upon oral administration, the esters are absorbed into the bloodstream where they are hydrolyzed to release the antibacterially active parent penicillin, nafcillin.Type: GrantFiled: July 10, 1978Date of Patent: July 29, 1980Assignee: Beecham Group LimitedInventor: Harry Ferres
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Patent number: 4166817Abstract: New penicillin antibiotics are disclosed which are effective antibacterial agents and which belong to the class of .alpha.-(heterocyclic acylamino) penicillins and their salts and esters together with pharmaceutical compositions containing the same and their method of administration. The new compounds are characterized by having an amino substituent on the heterocyclic ring which is linked through an acylamino group to the .alpha.-carbon atom of the penicillin side chain. Procedure for preparing the new penicillins is described as well as the antibacterial activity of exemplary compounds against typical microorganisms.Type: GrantFiled: March 13, 1978Date of Patent: September 4, 1979Assignee: Beecham Group LimitedInventors: Harry Ferres, Frank P. Harrington
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Patent number: 4150157Abstract: A class of substituted aminoalkyl esters of methicillin have good oral absorption properties.Type: GrantFiled: September 16, 1977Date of Patent: April 17, 1979Assignee: Beecham Group LimitedInventor: Harry Ferres
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Patent number: 4081546Abstract: A class of substituted aminocycloalkyl esters of penicillins have improved pharmacokinetic properties and are hydrolysed to the antibacterially active penicillin.Type: GrantFiled: June 20, 1977Date of Patent: March 28, 1978Assignee: Beecham Group LimitedInventor: Harry Ferres
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Patent number: 4036829Abstract: Lactonyl esters of Penicillins of the formula ##STR1## WHEREIN R.sup.1 is an antibacterially active penicillin-completing side chain; R is hydrogen, methyl or phenyl; and Ra, Rb, Rc, Rd are hydrogen, lower alkyl, lower alkoxy, halo, and nitro, provided that when R is hydrogen and R.sup.1 is D-.alpha.-aminophenylacetamido and Ra, Rb, Rc, and Rd are not all hydrogen are disclosed to possess antibacterial properties.Type: GrantFiled: August 5, 1976Date of Patent: July 19, 1977Assignee: Beecham Group LimitedInventors: Harry Ferres, John Peter Clayton
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Patent number: 3987032Abstract: The invention provides penicillins of formula (I) their pharmaceutically acceptable salts and esters, a process for their preparation and intermediates from which they may be prepared.Type: GrantFiled: June 3, 1975Date of Patent: October 19, 1976Assignee: Beecham Group LimitedInventor: Harry Ferres
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Patent number: 3981866Abstract: Mono-esters of .alpha.-carboxypenicillins and their preparation are described including intermediates for the mono-esters. The mono-esters are esterified on the .alpha.-carboxy group. They are well absorbed orally and de-esterified in vivo to give high serum concentrations of the parent .alpha.-carboxypenicillins.Type: GrantFiled: September 21, 1973Date of Patent: September 21, 1976Assignee: Beecham Group LimitedInventors: John Peter Clayton, Harry Ferres
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Patent number: 3963702Abstract: The phthalide ester of 6-[D(-)a-aminophenylacetamido] penicillanic acid and intermediates therefor are described. The phthalide penicillin ester is orally administered to obtain high serum concentrations of the parent penicillin.Type: GrantFiled: March 4, 1974Date of Patent: June 15, 1976Assignee: Beecham Group LimitedInventors: Harry Ferres, John Peter Clayton
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Patent number: 3963704Abstract: This invention relates to a novel class of esters of penicillins and cephalosporins which, upon oral administration are absorbed into the bloodstream where they are split by enzymic action to release the antibacterially active parent penicillin or cephalosporin.Type: GrantFiled: December 9, 1974Date of Patent: June 15, 1976Assignee: Beecham Group LimitedInventor: Harry Ferres
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Patent number: 3962216Abstract: Aminoacylpenicillins are disclosed which possess a broad spectrum of antibacterial activity.Type: GrantFiled: January 22, 1975Date of Patent: June 8, 1976Assignee: Beecham Group LimitedInventors: Harry Ferres, Adrian Victor Kemmenoe, Desmond John Best
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Patent number: 3957759Abstract: New penicillins and their salts and esters particularly active against Gram-negative organisms such as Pseudomonas spp., and their preparation and administration. The penicillins are active against clinically important organisms against which well-known broad spectrum penicillins are inactive and may generally be designated as aminoacyldipeptide penicillins of unusual structure and properties.Type: GrantFiled: May 19, 1975Date of Patent: May 18, 1976Assignee: Beecham Group LimitedInventors: Harry Ferres, Adrian Victor Kemmenoe, Desmond John Best
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Patent number: 3939180Abstract: 3-CROTONOLACTONE 3-BISCROTONO-LACTANE PENICILLINS WHICH POSSESS ANTIBACTERIAL ACTIVITY ARE DISCLOSED.Type: GrantFiled: December 9, 1974Date of Patent: February 17, 1976Assignee: Beecham Group limitedInventors: Harry Ferres, John Peter Clayton
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Patent number: 3935192Abstract: New penicillins and their salts and esters particularly active against Gram-negative organisms such as Pseudomonas spp., and their preparation and administration. The penicillins are active against clinically important organisms against which well-known broad spectrum penicillins are inactive and may generally be designated as aminoacyldipeptide penicillins of unusual structure and properties.Type: GrantFiled: May 16, 1975Date of Patent: January 27, 1976Assignee: Beecham Group LimitedInventors: Harry Ferres, Adrian Victor Kemmenoe, Desmond John Best
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Patent number: 3935189Abstract: New penicillins and their salts and esters particularly active against Gram-negative organisms such as Pseudomonas spp., and their preparation and administration. The penicillins are active against clinically important organisms against which well-known broad spectrum penicillins are inactive and may generally be designated as aminoacyldipeptide penicillins of unusual structure and properties.Type: GrantFiled: May 15, 1975Date of Patent: January 27, 1976Assignee: Beecham Group LimitedInventors: Harry Ferres, Adrian Victor Kemmenoe, Desmond John Best
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Patent number: RE29650Abstract: .[.The.]. Phthalide ester of 6-[(D(-).alpha.-aminophenylacetamido] penicillanic acid and intermediates therefor .[.are described.].. The phthalide penicillin ester is orally administrable to provide high serum concentrations of the .Iadd.free acid form of the .Iaddend..[.parent.]. penicillin..[.This application is a division of application Ser. No. 259,560 filed June 5, 1972, now U.S. Pat. No. 3,860,579..]. .Iadd.Type: GrantFiled: August 18, 1977Date of Patent: May 30, 1978Assignee: Beecham Group LimitedInventor: Harry Ferres