Abstract: Compositions and methods are provided relating to rotavirus serotypes and antibodies that bind to human rotavirus and modifications thereto which enhance the immunogenicity of the rotavirus protein for vaccine development with respect to the generation of a neutralizing immune response. Further disclosed are methods of using the antibodies for treating a rotavirus-mediated disease in a subject.

Abstract: The present invention relates to recombinant HCMV (human cytomegalovirus) expressing a pp65 polypeptide or fragment thereof fused to a heterologous or non-native polypeptide, in particular immunogenic and/or antigenic polypeptides. In particular, the heterologous gene products include antigenic or immunogenic polypeptides from a variety of pathogens, cellular genes, tumor antigens, and viruses. The recombinant viruses may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.

Abstract: The present invention relates to recombinant HCMV (human cytomegalovirus) expressing a pp65 polypeptide or fragment thereof fused to a heterologous or non-native polypeptide, in particular immunogenic and/or antigenic polypeptides. In particular, the heterologous gene products include antigenic or immunogenic polypeptides from a variety of pathogens, cellular genes, tumor antigens, and viruses. The recombinant viruses may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.

Abstract: The present invention relates to novel recombinant polypeptide antigens that may comprise subunit vaccines against rotavirus infection. Further, the present invention relates to methods for use of said antigens in the diagnosis, treatment and prevention of rotavirus infection.

Abstract: An electrically directable antenna system is provided which is tunable to individual stations in the FM band. The antenna system includes a pair of crossed, forshortened dipole components which are arranged to be mutually perpendicular. Each of the dipole components includes a pair of longitudinally aligned arms which are flared at their outer ends so as to be shaped generally like an arrow. At their inner ends, these arms are connected to a narrow bandwidth tuner network which is designed to resonate the dipole components at a frequency corresponding to a selected station and to impedance match each of the dipole components to the input of the FM receiver. The tuner network includes a bandwidth control, which is operable to produce a predetermined impedance mismatch between the dipole components and the receiver input so that, without changing the frequency to which the antenna system is tuned, the overall antenna system gain can be made substantially constant over the entire FM band.