Patents by Inventor Harry Kleanthous

Harry Kleanthous has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TagA gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
    Patent number: 6153390
    Abstract: The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: November 28, 2000
    Assignee: Vanderbilt University
    Inventors: Timothy L. Cover, Martin J. Blaser, Harry Kleanthous, Murali K. R. Tummuru
  • Helicobacter TagA gene fusion protein
    Patent number: 5876943
    Abstract: The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: March 2, 1999
    Assignee: Vanderbilt University
    Inventors: Timothy L. Cover, Martin J. Blaser, Harry Kleanthous, Murali K. R. Tummuru
  • Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma
    Patent number: 5733740
    Abstract: An isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
    Type: Grant
    Filed: September 30, 1994
    Date of Patent: March 31, 1998
    Assignees: Vanderbilt University, OraVax, Inc.
    Inventors: Timothy L. Cover, Martin J. Blaser, Harry Kleanthous, Murali K. R. Tummuru