Patents by Inventor Harry N. Antoniades

Harry N. Antoniades has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nerve regeneration
    Patent number: 6506727
    Abstract: It has been found that the growth factor PDGF, when used in combination with another growth factor such as IGF-I, acts synergistically with the other factor to promote neuronal regeneration.
    Type: Grant
    Filed: February 18, 1994
    Date of Patent: January 14, 2003
    Assignee: Institute of Molecular Biology, Inc.
    Inventors: Hans-Arne Hansson, Samuel E. Lynch, Harry N. Antoniades
  • Device to promote drug-induced nerve regeneration
    Patent number: 5656605
    Abstract: The invention relates generally to a system for promoting regeneration of a damaged nerve. In particular, the invention comprises: (1) a guide tube constructed to be attached to the damaged nerve; (2) guiding filaments disposed within the guide tube; and, (3) a therapeutic composition enclosed by the guide tube. Both the guide tube and the guiding filaments are composed of biologically compatible materials, while the therapeutic composition contains a nerve-growth-stimulating agent dispersed in a matrix-forming material. During treatment, the guide tube is inserted between the ends of lesioned nerves, resulting in the stimulation of axon growth.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: August 12, 1997
    Assignee: Institute of Molecular Biology, Inc.
    Inventors: Hans-Arne Hansson, Michael R. Wells, Samuel E. Lynch, Harry N. Antoniades
  • Wound healing using IGF-II and TGF
    Patent number: 5256644
    Abstract: Healing an external wound of a mammal by administering to the mammal a composition containing purified Insulin-like growth factor-I and purified transforming growth factor beta.
    Type: Grant
    Filed: March 25, 1992
    Date of Patent: October 26, 1993
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Method for periodontal regeneration
    Patent number: 5124316
    Abstract: A method for promoting bone, periodontium or ligament growth of a mammal comprising applying to the bone periodontium or ligament a growth-promoting amount of a composition comprising a partially purified or purified polypeptide growth factor.
    Type: Grant
    Filed: September 13, 1990
    Date of Patent: June 23, 1992
    Assignees: President and Fellows of Harvard College, Institute of Molecular Biology, Inc.
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Wound healing composition of IL-1 and PDGF or IGF-1
    Patent number: 5035887
    Abstract: Healing an external wound of a mammal by administering to the mammal a composition containing purified platelet-derived growth factor and purified interleukin-1 or administering to the mammal a composition containing purified insulin-like growth factor and interleukin-1.
    Type: Grant
    Filed: September 7, 1989
    Date of Patent: July 30, 1991
    Assignees: Institute of Moelcular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Process of wound healing using PDGF and EGF
    Patent number: 5034375
    Abstract: Healing an external wound of a mammal by administering to the mammal a composition containing purified EGF and purified PDGF in a weight to weight ratio of at least 5:1.
    Type: Grant
    Filed: August 10, 1988
    Date of Patent: July 23, 1991
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Wound healing using PDGF and IGF-II
    Patent number: 5019559
    Abstract: Healing an external wound or regenerating bone of a mammal by administering to the mammal a composition containing purified platelet-derived growth factor and purified insulin-like growth factor II.
    Type: Grant
    Filed: November 16, 1988
    Date of Patent: May 28, 1991
    Assignee: President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Wound healing composition of IGF-I and TGF-.beta.
    Patent number: 4983581
    Abstract: Healing an external wound of a mammal by administering to the mammal a composition containing purified Insulin-like growth factor-1 and purified transforming growth factor beta.
    Type: Grant
    Filed: May 20, 1988
    Date of Patent: January 8, 1991
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Wound headling composition of TGF-alpha and PDGF
    Patent number: 4874746
    Abstract: Healing an external wound or regenerating bone of a mammal by administering to the mammal a composition containing purified platelet-derived growth factor and purified transforming growth factor alpha.
    Type: Grant
    Filed: December 22, 1987
    Date of Patent: October 17, 1989
    Assignees: Institute of Molecular Biology, Inc., President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch
  • Wound healing and bone regeneration using PDGF and IGF-I
    Patent number: 4861757
    Abstract: Healing an external wound or regenerating bone of a mammal by administering to the mammal a composition containing purified platelet-derived growth factor and purified insulin-like growth factor.
    Type: Grant
    Filed: November 16, 1987
    Date of Patent: August 29, 1989
    Assignees: Institute of Molecular Biology, President and Fellows of Harvard College
    Inventors: Harry N. Antoniades, Samuel E. Lynch, Ray C. Williams
  • Method for extraction localization and direct recovery of platelet derived growth factor
    Patent number: 4479896
    Abstract: A process for the localization and direct recovery of active platelet derived growth factor (PDGF) from stained sodium dodecyl sulfate/polyacrylamide gels is provided. This technique allows the user to identify and obtain purified PDGF peptides without loss of active material or special instrumentation.
    Type: Grant
    Filed: July 8, 1983
    Date of Patent: October 30, 1984
    Inventor: Harry N. Antoniades