Abstract: A pneumatic valve with lockout for controlling the flow of a fluid includes a housing, a fluid flow passage extending through the housing between a fluid inlet and a fluid outlet, and a valve movable along an axis to open and close the flow passage. A pneumatic actuator is operable to move the valve to open and close the flow passage. A manual lockout device is actuable to selectively enable and disable the valve. The device includes a locking member movable to prevent actuation of the lockout device when the valve is disabled. A fitting on the housing to convey a pressurized gas to the pneumatic actuator is mounted to swivel about the housing for connection to an air source on any radial within 360°. The valve is compact, simple to connect in a system and safe.