Abstract: A method of treating a retinal disease in a subject in need thereof, the method comprising administering to the subject a vector that comprises a mirtron for knocking down expression of a target gene expressed in the retina and a gene therapy vector comprising a mirtron for rhodopsin knock-down.

Abstract: Adhesive compositions containing (1) one or two adhesive compositions produced from the fruit but not the seeds of Osage orange fruit and (2) a known adhesive. The one or two adhesive compositions produced from the fruit but not the seeds of Osage orange fruit are produced by a process involving drying the cut peel and mesocarp but not the seeds of the fruit of Osage orange to produce dried peel and mesocarp, milling the dried peel and mesocarp to produce milled peel and mesocarp, extracting the milled peel and mesocarp with an organic solvent (e.g., hexane) or a polar aprotic solvent (e.g., ethyl acetate) to produce the first adhesive composition, and optionally wherein the amorphous layer between the polar aprotic solvent and the milled peel and mesocarp is the second adhesive composition.

Abstract: A method of gene therapy in a subject in need thereof, the method comprising administering to the subject a vector that comprises a transgene for expression in the subject and a mirtron for knocking down expression of a gene in the subject, wherein the mirtron is in the 5?UTR of the transgene. Also a vector comprising a transgene for expression from the vector and a mirtron for knocking down expression of a gene, wherein the mirtron is in the 5?UTR of the transgene and wherein the 5?UTR further comprises an exonic splice enhancer motif and/or wherein the mirtron is flanked in the 5?UTR by a fragment of the coding region of a reporter gene, and methods for preparing a vector.

Abstract: Disclosed herein are polyketone triglyceride compositions containing 8 to 16 ketone carbonyl moieties per triglyceride unit and methods of making. Also disclosed are polyimine triglyceride compositions having has 8 to 16 nitrogen moieties per triglyceride unit and methods of making. Also disclosed are polyamine triglyceride compositions containing 8 to 16 nitrogen moieties per triglyceride unit and methods of making.

Abstract: Disclosed herein are polyketone triglyceride compositions containing 8 to 16 ketone carbonyl moieties per triglyceride unit and methods of making. Also disclosed are polyimine triglyceride compositions having has 8 to 16 nitrogen moieties per triglyceride unit and methods of making.

Abstract: Disclosed herein are polyketone triglyceride compositions containing 8 to 16 ketone carbonyl moieties per triglyceride unit and methods of making. Also disclosed are polyimine triglyceride compositions having has 8 to 16 nitrogen moieties per triglyceride unit and methods of making. Also disclosed are polyamine triglyceride compositions containing 8 to 16 nitrogen moieties per triglyceride unit and methods of making.

Abstract: An ignition transformer for use with a spark ignition system for an internal combustion engine includes a central core, a primary coil, a secondary coil, and a magnetic return. The central core defines a first end and a second end. The primary coil is used to vary magnetic energy into the central core in response to a primary current applied to the primary coil. The secondary coil is used to generate a secondary voltage in response to changes in the magnetic energy in the central core. The magnetic return defines a return-path to couple magnetic energy from the first end to the second end. A permeability value of the return-path is selected so the transformer has a secondary-current versus time-response characteristic that decays to fifty-percent (50%) of an initial secondary current when ten percent (10%) to twenty-five percent (25%) of a burn-time interval has passed.

Abstract: Disclosed herein are polyketone triglyceride compositions containing 8 to 16 ketone carbonyl moieties per triglyceride unit and methods of making. Also disclosed are polyimine triglyceride compositions having has 8 to 16 nitrogen moieties per triglyceride unit and methods of making. Also disclosed are polyamine triglyceride compositions containing 8 to 16 nitrogen moieties per triglyceride unit and methods of making.

Abstract: Disclosed herein are polyketone triglyceride compositions containing 8 to 16 ketone carbonyl moieties per triglyceride unit and methods of making. Also disclosed are polyimine triglyceride compositions having has 8 to 16 nitrogen moieties per triglyceride unit and methods of making. Also disclosed are polyamine triglyceride compositions containing 8 to 16 nitrogen moieties per triglyceride unit and methods of making.

Abstract: An ignition coil for delivering a spark-generating current to a spark plug includes a magnetically-permeable core; a primary winding disposed outward of the core; and a secondary winding radially surrounding the primary winding and inductively coupled to the primary winding, the secondary winding having a low-voltage end and a high-voltage end. The secondary winding includes a secondary winding first section proximal to the low-voltage end and having a first thickness. The secondary winding also includes a secondary winding second section proximal to the high-voltage end and having a second thickness that is less than the first thickness of the secondary winding first section.

Abstract: An ignition coil for delivering a spark-generating current to a spark plug includes a magnetically-permeable core; a primary winding disposed outward of the core; and a secondary winding disposed outward of the primary winding and inductively coupled to the primary winding. The secondary winding terminates at one end thereof in a low-voltage end and terminates at another end thereof in a high-voltage end. At least one of the low-voltage end of the secondary winding and the high-voltage end of the secondary winding is electrically connected directly to a terminal through an electrically conductive polymer.

Abstract: An ignition transformer for use with a spark ignition system for an internal combustion engine includes a central core, a primary coil, a secondary coil, and a magnetic return. The central core defines a first end and a second end. The primary coil is used to vary magnetic energy into the central core in response to a primary current applied to the primary coil. The secondary coil is used to generate a secondary voltage in response to changes in the magnetic energy in the central core. The magnetic return defines a return-path to couple magnetic energy from the first end to the second end. A permeability value of the return-path is selected so the transformer has a secondary-current versus time-response characteristic that decays to fifty-percent (50%) of an initial secondary current when ten percent (10%) to twenty-five percent (25%) of a burn-time interval has passed.

Abstract: Disclosed herein are polyketone triglyceride compositions containing 8 to 16 ketone carbonyl moieties per triglyceride unit and methods of making. Also disclosed are polyimine triglyceride compositions having has 8 to 16 nitrogen moieties per triglyceride unit and methods of making.

Abstract: An ignition coil for an internal combustion engine includes a magnetically-permeable core a primary winding disposed outward of the core, and a secondary winding disposed outward of the primary winding and inductively coupled to the primary winding. The secondary winding has a left secondary winding section and right secondary winding section. A first end of the left secondary winding section is in electrical contact with a first terminal for delivering a first spark-generating current to a first spark plug. A first end of the right secondary winding section is in electrical contact with a second terminal for delivering a second spark-generating current to a second spark plug. A second end of the first secondary winding and a second end of a the second secondary winding is connected to a third terminal for delivering a third spark-generating current to a third spark plug.

Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.

Abstract: An ignition coil for delivering a spark-generating current to a spark plug includes a magnetically-permeable core; a primary winding disposed outward of the core; and a secondary winding radially surrounding the primary winding and inductively coupled to the primary winding, the secondary winding having a low-voltage end and a high-voltage end. The secondary winding includes a secondary winding first section proximal to the low-voltage end and having a first thickness. The secondary winding also includes a secondary winding second section proximal to the high-voltage end and having a second thickness that is less than the first thickness of the secondary winding first section.

Abstract: An ignition coil includes a magnetically-permeable core, a primary winding disposed outward of the core, and a secondary winding disposed outward of the primary winding and inductively coupled to the primary winding. The secondary winding includes a left secondary winding section wound clockwise around the primary winding and a right winding section wound counterclockwise around the primary winding. The left secondary winding section has i) a first left winding end distal from the right winding section and ii) a second left winding end that is proximal to the right winding section. The right secondary winding section has i) a first right winding end distal from the left winding section and ii) a second right winding end that is proximal to the left winding section. The second left winding end and the second right winding end are connected to a terminal.

Abstract: An ignition coil for delivering a spark-generating current to a spark plug includes a magnetically-permeable core; a primary winding disposed outward of the core; and a secondary winding disposed outward of the primary winding and inductively coupled to the primary winding. The secondary winding terminates at one end thereof in a low-voltage end and terminates at another end thereof in a high-voltage end. At least one of the low-voltage end of the secondary winding and the high-voltage end of the secondary winding is electrically connected directly to a terminal through an electrically conductive polymer.

Abstract: An ignition coil for an internal combustion engine includes a magnetically-permeable core extending along a core longitudinal axis, the core having a pair of end surfaces on axially-opposite ends thereof. The ignition coil also includes a primary winding disposed outward of the core, a secondary winding disposed outward of the primary winding, and a structure comprising magnetically-permeable steel laminations having a base and a pair of legs, the structure defining a magnetic return path. The core is disposed between the pair of legs such that the core longitudinal axis extends through the legs and the end surfaces face toward the legs and at least one of the end surfaces of the core is spaced apart from a respective one of the legs to define an air gap. The structure is over-molded with an over-molding material such that the over-molding material fills at least a portion of the air gap.

Abstract: A new crystalline polymorph of ritonavir and methods for its use and preparation are disclosed.