Patents by Inventor Harry Owen

Harry Owen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220178830
    Abstract: Raman systems and methods use advantages offered by increased laser mobility/path length and photon migration to analyze diffusively scattering solids, including pharmaceuticals. A collimated laser excitation beam having a first diameter induces from a sample a backscattered collimated Raman collection beam with a second diameter. The collimated laser excitation beam and the collimated Raman collection beam form a counter-propagating collimated optical path, and the collimated laser excitation beam is preferably smaller in diameter than the diameter of the backscattered collimated Raman beam. The collection beam to a spectrograph for Raman analysis of the sample. A Raman calibration standard may be placed in the collimated optical path, and/or the sample may be supported in a reflective holder that may be at least partially spherical and/or may form part of a multi-well plate. The counter-propagating collimated optical path may be contained within a Raman microscope.
    Type: Application
    Filed: December 6, 2021
    Publication date: June 9, 2022
    Inventor: Harry Owen
  • Patent number: 11086123
    Abstract: Achromatically corrected Raman immersion probes minimize chromatic and/or spherical aberration through the use of an achromat, apochromat, refractive/diffractive optics as opposed to a single lens geometry. The improved end optics are adapted for use with a probe body carrying a laser excitation and/or collection beam associated with Raman analysis. The achromatically corrected optic to focus the beam onto or within a sample. The sample may be a gas, a liquid, or a partial liquid such as a slurry. The achromatically corrected optic may be an achromat comprising a lens doublet or an achromat comprising a lens triplet or more optical elements. In one preferred embodiment, the achromatically corrected optic may be an apochromatic optic. A disclosed system includes the achromatically corrected end optic and Raman probehead operative to send and receive counter-propagating laser excitation and collection beams.
    Type: Grant
    Filed: February 4, 2020
    Date of Patent: August 10, 2021
    Inventor: Harry Owen
  • Patent number: 10976259
    Abstract: Immersion Raman probes use collimated light as opposed to a diverging fiber bundle or lens-based focusing geometry to deliver and collect light to and from a sample, thereby eliminating problems associated with chromatic aberration. The probes convey counter-propagating excitation and collection beams to and from a distally sealed, signal-transmissive optical component such as a window immersed, in contact with, or otherwise exposed to a sample volume. The counter-propagating excitation and collection beams pass directly through the sealed optical component and into the sample volume in collimated form for Raman analysis thereof. The probe may further include a baffled sample chamber coupled to the distal end of the probe optic body, with one or more optical elements to reflect the counter-propagating beams. The sample chamber may be fixed or axially movable to facilitate path length adjustment. The invention finds utility in process Raman, microscopy and other applications.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: April 13, 2021
    Inventor: Harry Owen
  • Patent number: 10746596
    Abstract: Spectroscopic probe light shields coupled to the end of an optical probe improve user safety, reduce unwanted stray light and enhance signal collection from a liquid or gaseous sample. Apertured inner and outer baffles with offset perforations allow a sample to flow through the baffles and past a counter-propagating focused or collimated excitation/collection beam. The spectroscopic probe may be a Raman or fluorescence probe, operating in the UV-visible or mid-IR region of the spectrum. The inner shield may include a retro-reflector to amplify light collection from the sample, or the inner shield may include a light absorber to reduce the intensity of a scattered excitation beam. One or both of the inner and outer shields may be cylindrical, and the apertures in the baffles may be slots, circles or other shapes. The baffle(s) may be adapted for temporary, permanent, or semi-permanent attachment to the distal end of the probe optic.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: August 18, 2020
    Inventor: Harry Owen
  • Publication number: 20200257110
    Abstract: Achromatically corrected Raman immersion probes minimize chromatic and/or spherical aberration through the use of an achromat, apochromat, refractive/diffractive optics as opposed to a single lens geometry. The improved end optics are adapted for use with a probe body carrying a laser excitation and/or collection beam associated with Raman analysis. The achromatically corrected optic to focus the beam onto or within a sample. The sample may be a gas, a liquid, or a partial liquid such as a slurry. The achromatically corrected optic may be an achromat comprising a lens doublet or an achromat comprising a lens triplet or more optical elements. In one preferred embodiment, the achromatically corrected optic may be an apochromatic optic. A disclosed system includes the achromatically corrected end optic and Raman probehead operative to send and receive counter-propagating laser excitation and collection beams.
    Type: Application
    Filed: February 4, 2020
    Publication date: August 13, 2020
    Inventor: Harry Owen
  • Publication number: 20200116639
    Abstract: Immersion Raman probes use collimated light as opposed to a diverging fiber bundle or lens-based focusing geometry to deliver and collect light to and from a sample, thereby eliminating problems associated with chromatic aberration. The probes convey counter-propagating excitation and collection beams to and from a distally sealed, signal-transmissive optical component such as a window immersed, in contact with, or otherwise exposed to a sample volume. The counter-propagating excitation and collection beams pass directly through the sealed optical component and into the sample volume in collimated form for Raman analysis thereof. The probe may further include a baffled sample chamber coupled to the distal end of the probe optic body, with one or more optical elements to reflect the counter-propagating beams. The sample chamber may be fixed or axially movable to facilitate path length adjustment. The invention finds utility in process Raman, microscopy and other applications.
    Type: Application
    Filed: October 8, 2019
    Publication date: April 16, 2020
    Inventor: Harry Owen
  • Publication number: 20190383662
    Abstract: Spectroscopic probe light shields coupled to the end of an optical probe improve user safety, reduce unwanted stray light and enhance signal collection from a liquid or gaseous sample. Apertured inner and outer baffles with offset perforations allow a sample to flow through the baffles and past a counter-propagating focused or collimated excitation/collection beam. The spectroscopic probe may be a Raman or fluorescence probe, operating in the UV-visible or mid-IR region of the spectrum. The inner shield may include a retro-reflector to amplify light collection from the sample, or the inner shield may include a light absorber to reduce the intensity of a scattered excitation beam. One or both of the inner and outer shields may be cylindrical, and the apertures in the baffles may be slots, circles or other shapes. The baffle(s) may be adapted for temporary, permanent, or semi-permanent attachment to the distal end of the probe optic.
    Type: Application
    Filed: June 14, 2019
    Publication date: December 19, 2019
    Inventor: Harry Owen
  • Patent number: 10139329
    Abstract: The present disclosure is directed to a method of particle size determination for particles suspended within a light-transmissive medium. The method includes directing a monochromatic light source into the medium and collecting from the medium a Raman-scattered light spectrum. The method includes analyzing the Raman spectrum to determine an amount of Tyndall scattering of the Raman spectrum caused by particles within the medium, and thus determine the size and the number of particles mediating the Tyndall scattering.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: November 27, 2018
    Assignee: Kaiser Optical Systems Inc.
    Inventor: Harry Owen
  • Publication number: 20180106712
    Abstract: The present disclosure is directed to a method of particle size determination for particles suspended within a light-transmissive medium. The method includes directing a monochromatic light source into the medium and collecting from the medium a Raman-scattered light spectrum. The method includes analyzing the Raman spectrum to determine an amount of Tyndall scattering of the Raman spectrum caused by particles within the medium, and thus determine the size and the number of particles mediating the Tyndall scattering.
    Type: Application
    Filed: October 16, 2017
    Publication date: April 19, 2018
    Inventor: Harry Owen
  • Patent number: 8675190
    Abstract: A compact Raman analysis system combines a near-infrared (NIR) laser source, a 2D array collecting anti-Stokes Raman spectra, and a probe configured to measure complex solid samples, including pharmaceutical tablets and other large-area targets with reduced background fluorescence at relatively low cost. The system collects spectra from an area of 1-mm or greater, preferably 3-12 mm or more, facilitating the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: March 18, 2014
    Assignee: Kaiser Optical Systems
    Inventors: Harry Owen, Kevin L. Davis
  • Publication number: 20120300201
    Abstract: A compact Raman analysis system combines a near-infrared (NIR) laser source, a 2D array collecting anti-Stokes Raman spectra, and a probe configured to measure complex solid samples, including pharmaceutical tablets and other large-area targets with reduced background fluorescence at relatively low cost. The system collects spectra from an area of 1-mm or greater, preferably 3-12 mm or more, facilitating the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities.
    Type: Application
    Filed: May 27, 2011
    Publication date: November 29, 2012
    Applicant: Kaiser Optical Systems
    Inventors: Harry Owen, Kevin L. Davis
  • Patent number: 7148963
    Abstract: A compact Raman/fluorescence probe is capable of collecting spectra from a relatively large spot size as compared to traditional confocal Raman probes. The inventive probe collects spectra from an area or 1 mm or greater, preferably 3–12 mm or more, compared to current instruments which utilize spot sizes on the order of 2–60 microns. The larger spot size facilitates the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding, and reactor cleanliness validation.
    Type: Grant
    Filed: December 9, 2004
    Date of Patent: December 12, 2006
    Assignee: Kaiser Optical Systems
    Inventors: Harry Owen, David J. Strachan, Joseph B. Slater, James M. Tedesco
  • Publication number: 20050140973
    Abstract: A compact Raman/fluorescence probe is capable of collecting spectra from a relatively large spot size as compared to tradition confocal Raman probes. The inventive probe collects spectra from an area of 1 mmm or greater, preferably 3-12 mm or more, compared to current instruments which utilize spot sizes on the order of 2-60 microns. The larger spot size facilitates the collection of statistically useful data from inhomogeneous and laser-sensitive samples, among other applications. Potential pharmaceutical applications include tablet dosage level measurements, as well as online and at-line quality-control (QC) monitoring opportunities. Other applications include tablet identification as a forensic tool to identify counterfeit pharmaceutical products; granulation and blend uniformity for improved formulation via better process understanding, and reactor cleanliness validation.
    Type: Application
    Filed: December 9, 2004
    Publication date: June 30, 2005
    Inventors: Harry Owen, David Strachan, Joseph Slater, James Tedesco
  • Patent number: 6867858
    Abstract: A method of monitoring sample crystallization from a solution. The method includes the collection of multiple Raman spectra from a sample dissolved in a solvent as a function of time and under conditions promoting crystallization. Within each of the multiple Raman spectra, a first signal is identified corresponding to the sample associated with the solvent. A second signal corresponding to the sample in a microcrystallite state is also identified. Thereafter, the intensity of the multiple Raman spectra are measured for an increase relating to formation of the sample in a microcrystallite state. A method of monitoring sample crystallization from a solution as a function of turbidity is also disclosed. The method includes the collection of multiple Raman spectra from a sample dissolved in a solvent as a function of time under conditions promoting crystallization.
    Type: Grant
    Filed: February 18, 2003
    Date of Patent: March 15, 2005
    Assignee: Kaiser Optical Systems
    Inventors: Harry Owen, Mark Welch, Michael J. Pelletier
  • Publication number: 20040004714
    Abstract: A method of monitoring sample crystallization from a solution. The method includes the collection of multiple Raman spectra from a sample dissolved in a solvent as a function of time and under conditions promoting crystallization. Within each of the multiple Raman spectra, a first signal is identified corresponding to the sample associated with the solvent. A second signal corresponding to the sample in a microcrystallite state is also identified. Thereafter, the intensity of the multiple Raman spectra are measured for an increase relating to formation of the sample in a microcrystallite state. A method of monitoring sample crystallization from a solution as a function of turbidity is also disclosed. The method includes the collection of multiple Raman spectra from a sample dissolved in a solvent as a function of time under conditions promoting crystallization.
    Type: Application
    Filed: February 18, 2003
    Publication date: January 8, 2004
    Inventors: Harry Owen, Mark Welch, Michael J. Pelletier
  • Patent number: 5559597
    Abstract: An optical spectrograph utilizes a plurality of holographic transmission optical gratings operative to receive an incoming source of light to be analyzed and diffract the light such that different spectral components impinge upon spatially separated regions of an opto-electronic detector. Various grating configurations are disclosed, including a physical stack of gratings conducive to extreme compactness, as well as a spaced-apart configuration used to preclude spectral cross talk in certain configurations. Diverging light emerging from a fiber-optic bundle is collimated by a first lens assembly prior to passing through the gratings, and a second lens assembly is used to focus the diffracted light onto the detectors, preferably in the form of a two-dimensional CCD array.
    Type: Grant
    Filed: May 30, 1995
    Date of Patent: September 24, 1996
    Assignee: Kaiser Optical Systems, Inc.
    Inventors: David E. Battey, Harry Owen, James M. Tedesco
  • Patent number: 5530565
    Abstract: A narrow bandwidth bandpass filter having high transmission efficiency for the passband and excellent out-of-band attenuation employs a transmission holographic grating sandwiched between the oblique faces of a pair of right angle glass prisms. An incoming laser beam to be filtered is incident normal to one of the prism faces so as to intersect the holographic grating at about 45.degree.. The grating frequency is such as to diffract light of the transmission wavelength through substantially 90.degree. so that it exits the cube formed by the two prisms from the right angle face of the second prism. The out-of-band wavelengths of the incident beam are either transmitted unaffected through the grating or diffracted at a different angle than the light of the transmission wavelength.
    Type: Grant
    Filed: October 26, 1994
    Date of Patent: June 25, 1996
    Assignee: Kaiser Optical Systems, Inc.
    Inventor: Harry Owen
  • Patent number: 5442439
    Abstract: An optical spectrograph utilizes a plurality of holographic transmission optical gratings operative to receive an incoming source of light to be analyzed and diffract the light such that different spectral components impinge upon spatially separated regions of an opto-electronic detector. Various grating configurations are disclosed, including a physical stack of gratings conducive to extreme compactness, as well as a spaced-apart configuration used to preclude spectral cross talk in certain configurations. Diverging light emerging from a fiber-optic bundle is collimated by a first lens assembly prior to passing through the gratings, and a second lens assembly is used to focus the diffracted light onto the detectors, preferably in the form of a two-dimensional CCD array.
    Type: Grant
    Filed: April 21, 1993
    Date of Patent: August 15, 1995
    Assignee: Kaiser Optical Systems, Inc.
    Inventors: David E. Battey, Harry Owen, James M. Tedesco
  • Patent number: 5377004
    Abstract: A holographic probe facilitates the measurement of radiative effects such as Raman scattering or fluorescence of a remotely disposed sample. Improving upon prior-art techniques, the probe teaches a substantially in-line path between the sample and an output optic wherein a narrowband reflective element, preferably holographically recorded, is used to fold excitation energy from an illumination path into the collection path and reject any Rayleigh scattering received from the sample. The improved configuration further allows a dispersive filtering element to be placed in the illumination path, which may be used in conjunction with spatial filtering to reject non-excitation wavelengths.
    Type: Grant
    Filed: October 15, 1993
    Date of Patent: December 27, 1994
    Assignee: Kaiser Optical Systems
    Inventors: Harry Owen, James M. Tedesco, Joseph B. Slater
  • Patent number: 5011284
    Abstract: The Raman scattering detector of this invention includes a source of collimated monochromatic illumination, a cube formed of two right angle prisms, a holographic optical element disposed between the prisms, a concentrating lens, a focusing lens and one or more photo detectors. The illuminating beam passes through the cube and is concentrated by the concentrating leans to a sample. Scattered light returned to the concentrating lens is substantially collimated upon return to the cube. The holographic optical element diffracts light at desired Raman wavelengths approximately 90 degrees without substantially affecting the original wavelength. The holographic optical element further disperses light at desired Raman wavelengths permitting them to be separated. The diffracted and dispersed wavelengths are focused on one or more detectors by the focusing lens.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: April 30, 1991
    Assignee: Kaiser Optical Systems
    Inventors: James M. Tedesco, Harry Owen, Byung J. Chang