Patents by Inventor Harry R. Dalton

Harry R. Dalton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Infectious hepatitis E virus genotype 3 recombinants
    Patent number: 9850468
    Abstract: The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: December 26, 2017
    Assignees: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, ROYAL CORNWALL HOSPITAL TRUST
    Inventors: Suzanne U. Emerson, Priyanka Shukla, Hanh T. Nguyen, Robert H. Purcell, Harry R. Dalton, Richard Bendall
  • INFECTIOUS HEPATITIS E VIRUS GENOTYPE 3 RECOMBINANTS
    Publication number: 20160102296
    Abstract: The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus.
    Type: Application
    Filed: October 20, 2015
    Publication date: April 14, 2016
    Inventors: Suzanne U. Emerson, Priyanka Shukla, Hanh T. Nguyen, Robert H. Purcell, Harry R. Dalton, Richard Bendall
  • Infectious hepatitis E virus genotype 3 recombinants
    Patent number: 9181530
    Abstract: The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus. The invention relates, in part, on the identification of a new strain of HEV genotype 3 virus. Strain Kernow-C1 (genotype 3) of HEV, which was isolated from a chronically infected patient, was used to identify human, pig and deer cell lines permissive for infection. Adaptation of the Kernow-C 1 strain to growth in human hepatoma cells selected for a rare virus recombinant that contained an insertion of 174 ribonucleotides (58 amino acids) of a human ribosomal protein gene and additional mutations.
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: November 10, 2015
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Royal Cornwall Hospital Trust
    Inventors: Suzanne U. Emerson, Priyanka Shukla, Hanh T. Nguyen, Robert H. Purcell, Harry R. Dalton, Richard Bendall
  • INFECTIOUS HEPATITIS E VIRUS GENOTYPE 3 RECOMBINANTS
    Publication number: 20130302790
    Abstract: The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus. The invention relates, in part, on the identification of a new strain of HEV genotype 3 virus. Strain Kernow-C1 (genotype 3) of HEV, which was isolated from a chronically infected patient, was used to identify human, pig and deer cell lines permissive for infection. Adaptation of the Kernow-C 1 strain to growth in human hepatoma cells selected for a rare virus recombinant that contained an insertion of 174 ribonucleotides (58 amino acids) of a human ribosomal protein gene and additional mutations.
    Type: Application
    Filed: January 10, 2012
    Publication date: November 14, 2013
    Applicants: Royal Cornwall Hospital Trust, The Government of the United States of America, as represented by the Secretary, Department of Healt
    Inventors: Suzanne U. Emerson, Priyanka Shukla, Hanh T. Nguyen, Robert H. Purcell, Harry R. Dalton, Richard Bendall