Abstract: A composition comprising a high molecular weight, water soluble polymer having a cloud point from about 20 to about 90° C. and at least one carrageenan is provided. The composition may be used as a component of a pharmaceutical dosage form, such as the shell of a dosage form, to provide burst release of active ingredient contained therein.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: An immediate release tablet is provided. The tablet comprises at least 60 weight % of an active ingredient and powdered wax having a melting point greater than about 90° C. The tablet may advantageously be produced by direct compression. Although the wax is hydrophobic, the tablet has excellent disintegration.

Abstract: A dosage form comprises: (a) at least one active ingredient; (b) a core; and(c) a shell which surrounds the core, wherein the shell is substantially free of pores having a diameter of 0.5-5.0 microns, and the shell comprises a first shell portion and a second shell portion which are compositionally different and the dosage form provides a modified release profile of the active ingredient upon contacting of the dosage form with a liquid medium.

Abstract: A modified release dosage form comprising at least one active ingredient and at least two cores surrounded by a shell is provided. The shell comprises at least one opening and provides for modified release of active ingredient upon contacting of the dosage form with a liquid medium. At least one of the cores is distal from the opening. In a preferred embodiment, the dosage form has a pulsatile release profile.

Abstract: The invention provides a dosage form comprising at least one active ingredient, and first core and second cores surrounded by and separated by a shell. The dosage form provides a delay of at least one hour between the initial release of active ingredient contained in said first core and the initial release of active ingredient contained in said second core after contacting of the dosage form with a liquid medium.

Abstract: A dosage form comprises: (a) at least one active ingredient; (b) a core having an outer surface; and (c) a shell which resides upon at least a portion of the core outer surface, wherein at least a portion of the shell is semipermeable, such that the liquid medium diffuses through the semipermeable shell or shell portion to the core due to osmosis. The shell also provides for delivery of the active ingredient to a liquid medium outside the shell after contacting of the dosage form with the liquid medium. The dosage form delivers one or more active ingredients in a controlled manner upon contacting of the dosage form with a liquid medium. The dosage form may be employed to provide a burst release of the active ingredient, or to provide release of the active ingredient at an ascending release rate over an extended time period upon contacting of the dosage form with a liquid medium.

Abstract: An edible solid composition comprises: (a) about 25 to about 40 weight percent of at least one non-aqueous carrier material which has a melting temperature less than about 45 degrees C.; and (b) about 15 to about 60 weight percent of at least one thermoplastic material which has a melting temperature greater than about 50 degrees C. The composition may optionally additionally contain up to about 40 weight percent of at least one compatibility material for retaining the non-aqueous carrier material in the edible solid composition. The compatibility material is selected from the group consisting of emulsifiers, acrylic polymers, waxes and combinations thereof. The edible solid composition may be used as a core or shell in a dosage form, or as a dosage form per se which contains or is prepared from such an edible solid composition.

Abstract: A composition comprising a high molecular weight, water soluble polymer having a cloud point from about 20 to about 90° C. and a gelling polymer is provided. The composition may be used as a component of a pharmaceutical dosage form, such as the shell of a dosage form, or as an edible matrix, i.e., a pharmaceutical dosage form per se.

Abstract: An apparatus for continuously transferring substrates such as tablets from a rotary, double-sided tablet press to a second location is provided. The apparatus comprises a flexible conveying means on which transfer units adapted to receive the substrates are mounted. The flexible conveying means travels along a path that is coincident with those portions of the tablet press where tablets are ejected.

Abstract: The invention provides an immediate release dosage form having a solid core and a shell readily soluble in gastrointestinal fluids. The dosage form also comprises one or more openings in the shell.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: Systems, methods and apparatuses for manufacturing dosage forms, and to dosage forms made using such systems, methods and apparatuses are provided. Novel compression, thermal cycle molding, and thermal setting molding modules are disclosed. One or more of such modules may be linked, preferably via novel transfer device, into an overall system for making dosage forms.

Abstract: A non-through score line is made in the exposed surface of the blister sheet of a blister package. The non-through score line extends from one edge of an individual blister unit to an opposite or adjacent edge, i.e., across the corner of the blister unit. When the blister unit is angulated or flexed back at the non-through score line, the blister sheet will fracture. The smaller portion of the fractured blister sheet, still bonded to a backing sheet, acts as a tab for peeling the backing sheet from the blister sheet exposing the blister contents. Camouflage lines on the blister sheet help hide the score line, thereby rendering the package highly child-resistant.

Abstract: A non-through score line is made in the exposed surface of the blister sheet of a blister package. The non-through score line extends from one edge of an individual blister unit to an opposite or adjacent edge, i.e., across the corner of the blister unit. When the blister unit is angulated or flexed back at the non-through score line, the blister sheet will fracture. The smaller portion of the fractured blister sheet, still bonded to a backing sheet, acts as a tab for peeling the backing sheet from the blister sheet exposing the blister contents. Camouflage lines on the blister sheet help hide the score line, thereby rendering the package highly child-resistant.

Abstract: A nozzle assembly is provided with a valve to enable the coating of low aspect ratio items such as tablets. In a preferred embodiment a valve is disclosed such that the vacuum forces acting on the surfaces of the valve are equal to the weight of the valve. This balancing of the weight of the valve and the vacuum forces allows gravity to be the primary motive force for actuation. The weight of the valve is used to detect a tablet, such that when a tablet is missing, the valve prevents any coating from being pulled into the nozzle.