Abstract: A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself.

Abstract: A dressing for application over a blistered area on a surface of the skin of a patient. The dressing including: a volume forming portion positioned over the blistered area; an adhesive portion positioned proximate to the volume forming portion for fixing the volume forming portion to the skin; and a potential energy storage mechanism for storing potential energy that would tend to increase a volume adjacent to the blistered area formed by the volume forming portion to create a vacuum adjacent the blistered area.

Abstract: The invention provides a treatment for congestive heart failure (CHF) in a patient. At least one pressure applicator is arranged externally around a body segment of the patient. Negative pressure, relative to atmospheric pressure, is applied to the body segment of the patient during cardiac systole using the pressure applicator, thereby reducing ventricular afterload in the patient. The negative pressure to the body segment of the patient is removed during cardiac diastole.

Abstract: A method and system for treating a patient having an acute myocardial infarction. Such system may comprise at least one tank having a pressurized gas contained therein, at least one housing having a shell and being adapted to at least partially surround a body segment of the patient, a hose/valve device for supplying the compressed gas from the tank to the housing; and a control device for controlling the flow of compressed gas from the tank to the housing in accordance with cardiac systole and cardiac diastolic of the patient to vary the pressure in synchronization with the patient's heart function. The system may be arranged within a moving vehicle, such as an ambulance, an airplane, or a ship.

Abstract: The effect of the action of collagenase in treating lesions containing collagen or mixed fibrin clots (e.g., burns or ulcers) is improved by applying collagenase to the wound in combination with an organogel and a phosphatidylcholine, of which lecithin is a readily available source, particularly when the collagenase is first mixed and stored with that choline and an organic solvent and is subsequently mixed with a second individually stored formulation comprising a gel-forming agent and water, the two formulations individually having satisfactory shelf lives and the resultant mixture being applied to the lesion promptly after being formed.

Abstract: A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself.

Abstract: A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself.

Abstract: The invention provides a treatment for congestive heart failure (CHF) in a patient. At least one pressure applicator is arranged externally around a body segment of the patient. Negative pressure, relative to atmospheric pressure, is applied to the body segment of the patient during cardiac systole using the pressure applicator, thereby reducing ventricular afterload in the patient. The negative pressure to the body segment of the patient is removed during cardiac diastole.

Abstract: A method and system for treating a patient having an acute myocardial infarction. Such system may comprise at least one tank having a pressurized gas contained therein, at least one housing having a shell and being adapted to at least partially surround a body segment of the patient, a hose/valve device for supplying the compressed gas from the tank to the housing; and a control device for controlling the flow of compressed gas from the tank to the housing in accordance with cardiac systole and cardiac diastolic of the patient to vary the pressure in synchronization with the patient's heart function. The system may be arranged within a moving vehicle, such as an ambulance, an airplane, or a ship.

Abstract: The effect of the action of collagenase in treating lesions containing collagen or mixed fibrin clots (e.g., burns or ulcers) is improved by applying collagenase to the wound in combination with an organogel and a phosphotidylcholine, of which lecithin is a readily available source, particularly when the collagenase is first mixed and stored with that choline and an organic solvent and is subsequently mixed with a second individually stored formulation comprising a gel-forming agent and water, the two formulations individually having satisfactory shelf lives and the resultant mixture being applied to the lesion promptly after being formed.

Abstract: A patient support for an external counterpulsation cardiac assist procedure. The patient support includes: a base; and at least one support connected to the base for maintaining at least a portion of the patient above a tabletop during a positive pressure portion of the external counterpulsation cardiac assist procedure. In one embodiment, the base is a tabletop and the at least one support is movably supported on the table top in lateral and/or vertical directions. In another embodiment, the base is higher than the tabletop and the at least one support is a sling.

Abstract: A patient support for an external counterpulsation cardiac assist procedure. The patient support includes: a base; and at least one support connected to the base for maintaining at least a portion of the patient above a tabletop during a positive pressure portion of the external counterpulsation cardiac assist procedure. In one embodiment, the base is a tabletop and the at least one support is movably supported on the table top in lateral and/or vertical directions. In another embodiment, the base is higher than the tabletop and the at least one support is a sling.

Abstract: The cardiac assist device includes a sealed tubular housing for externally applying positive and negative relative pressure to a limb in counterpulsation with heart function. The applicator is assembled, in situ, to provide customized fit. It includes a fabric or spongelike inner layer cut to size and situated around the limb. Initially deformable material is sized, sealed around the inner fabric layer and then secured by straps or the like to form a relatively rigid, non-expandable tubular shell. The shell may include an interior wall composed of a sheet of hard plastic or articulated sections of hard plastic or metal. The interior wall has a plurality of openings to the sealed shell interior. The exterior shell wall is positioned around the interior wall. The shell walls are spaced apart by radially and/or longitudinally extending spacer elements defining a multi-section air flow chamber between the walls. The interior shell wall and spacer elements may be integral.

Abstract: A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself.

Abstract: An applicator for applying an external counterpulsation to a body portion is provided. The applicator including: an outer shell for covering the body portion, the outer shell having a length in a longitudinal direction and a circumference in a circumferential direction; a balloon disposed in the outer shell, pressurization of which applies an external pressure to the body portion; and at least one anti-deformation member for reducing an amount of deformation of the outer shell caused by the pressurization of the balloon.

Abstract: A hollow tubular element is inserted in the descending aorta. The caudad end contains a pressure sensitive passive or preferably, hydraulically or electrically activated, unidirectional valve. A flexible diaphragm situated in a rigid shell affixed over an opening in the element wall divides the shell interior into first and second variable volume chambers. The first chamber opens to the artery. A continuously operating electrical pump is connected to the second chamber through a closed hydraulic system including a multi-valve chamber. The valves regulate fluid flow to the second chamber in accordance with electrical signals from the heart. Fluid flow is directed to the second chamber during cardiac diastole and away from the second chamber during cardiac systole, causing the device to function in a counterpulsation mode. The work of the heart is decreased and coronary blood flow is increased to promote the formation of new coronary collateral channels and the perfusion of the heart itself.

Abstract: A method for facilitating the healing of damaged skin of a patient. The method including: isolating the damaged skin in an enclosure having an air-tight seal between a portion of the enclosure and adjacent skin, the enclosure and skin forming a chamber; and applying cycles of positive and negative pressure in the chamber to enhance blood flow to outer layers of the damaged skin and inhibit the formation of edema in the damaged skin. Preferably, the method further includes: detecting a cardiac cycle of the patient; and wherein the applying comprises synchronizing the application of the positive and negative pressure in the chamber to the detected cardiac cycle.

Abstract: A patient support for an external counterpulsation cardiac assist procedure. The patient support includes: a base; and at least one support connected to the base for maintaining at least a portion of the patient above a tabletop during a positive pressure portion of the external counterpulsation cardiac assist procedure. In one embodiment, the base is a tabletop and the at least one support is movably supported on the table top in lateral and/or vertical directions. In another embodiment, the base is higher than the tabletop and the at least one support is a sling.

Abstract: An applicator for applying an external counterpulsation to a body portion is provided. The applicator including: an outer shell for covering the body portion, the outer shell having a length in a longitudinal direction and a circumference in a circumferential direction; a balloon disposed in the outer shell, pressurization of which applies an external pressure to the body portion; and at least one anti-deformation member for reducing an amount of deformation of the outer shell caused by the pressurization of the balloon.

Abstract: The debridement of wounds, and particularly burn wounds, is more effectively accomplished by starting with a first substance comprising a mixture of collagenase and a non-aqueous excipient and a second substance comprising an aqueous excipient and, preferably, a cream such as an antibiotic cream, both of which substances have a satisfactory shelf life, and treating the wound by combining those two substances and promptly applying the resulting combination to the wound. Shelf life requirements are satisfied, and the effect of applying the resulting combination to the wound promptly after the combination has been formed results in a more effective debridement than would be expected from the application of other collagenase substances.