Abstract: Methods, systems, and computer storage media for providing an integrated onboarding platform associated with an onboarding management engine of a human resources management system. The integrated onboarding platform provides integrated onboarding management based on a computing architecture that supports system integration and process integration associated with an onboarding workflow. The onboarding management engine operates based on organizational onboarding logistics and hierarchical integration of onboarding activities of the onboarding workflow having onboarding interfaces. Operationally, a request for onboarding data is received at the onboarding management engine. The onboarding data is associated with an onboarding experience. The onboarding management engine supports generating onboarding plans, the onboarding plans are associated with onboarding configuration data of the integrated onboarding platform comprising onboarding management data from a plurality of data sources and services.

Abstract: This document relates to methods and materials for treating a mammal having an autoimmune disease. For example, materials and methods for producing a T cell comprising a FOXP3 polypeptide and a microRNA are provided herein. Also provided are methods of treating an autoimmune disease that include administering these T cells.