Patents by Inventor Harshil Dhruv

Harshil Dhruv has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMINOPYRIMIDINYLAMINOBENZONITRILE DERIVATIVES AS NEK2 INHIBITORS
    Publication number: 20230090742
    Abstract: The present invention provides aminopyrimidinylaminobenzonitrile compounds that inhibit the activity of never in mitosis gene A-related kinase 2 (NEK2) and are useful in the treatment of diseases related to activity of NEK2, including cancer (e.g., multiple myeloma, and breast, liver, pancreatic and colorectal cancers).
    Type: Application
    Filed: January 29, 2021
    Publication date: March 23, 2023
    Inventors: Adam Siddiqui-Jain, Steven L. Warner, Harshil Dhruv
  • Methods of sensitizing a patient with glioma to a therapeutic agent by administering small hairpin RNA targeting PDZ-RHOGEF
    Patent number: 10624895
    Abstract: The technology encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: April 21, 2020
    Assignees: The Translational Genomics Research Institute, Mayo Foundation for Medical Education and Research
    Inventors: Nhan Tran, Joseph C. Loftus, Harshil Dhruv
  • Methods used to treat cancer
    Patent number: 10426777
    Abstract: The invention encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: October 1, 2019
    Assignees: The Translational Genomics Research Institute, Mayo Foundation for Medical Education and Research
    Inventors: Nhan Tran, Joseph C. Loftus, Harshil Dhruv
  • METHODS USED TO TREAT CANCER
    Publication number: 20190054089
    Abstract: The technology encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.
    Type: Application
    Filed: April 8, 2016
    Publication date: February 21, 2019
    Inventors: Nhan Tran, Joseph C. Loftus, Harshil Dhruv
  • METHODS USED TO TREAT CANCER
    Publication number: 20180092922
    Abstract: The invention encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.
    Type: Application
    Filed: December 14, 2017
    Publication date: April 5, 2018
    Inventors: Nhan Tran, Joseph C. Loftus, Harshil Dhruv
  • Methods of using propentofylline to treat glioma and glioblastoma
    Patent number: 9872857
    Abstract: The invention encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: January 23, 2018
    Assignees: The Translational Genomics Research Institutet, Mayo Foundation for Medical Education and Research
    Inventors: Nhan Tran, Joseph C. Loftus, Harshil Dhruv
  • Method of screening for a compound for inhibitory activity of FN14-tweak interaction
    Patent number: 9797882
    Abstract: The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: October 24, 2017
    Assignee: The Translational Genomics Research Institute
    Inventors: Nhan Tran, Nathalie Meurice, Harshil Dhruv, Hongwei Yin
  • METHODS USED TO TREAT CANCER
    Publication number: 20160220571
    Abstract: The invention encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.
    Type: Application
    Filed: March 14, 2016
    Publication date: August 4, 2016
    Applicants: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE, MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: NHAN TRAN, JOSEPH C. LOFTUS, HARSHIL DHRUV
  • COMPOSITIONS AND METHODS OF SCREENING FOR COMPOUNDS THAT MODULATE ACTIVITY AT A TWEAK BINDING SITE ON A CRD OF FN14
    Publication number: 20160146784
    Abstract: The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.
    Type: Application
    Filed: July 9, 2014
    Publication date: May 26, 2016
    Inventors: Nhan Tran, Nathalie Meunice, Harshil Dhruv, Hongwei Yin
  • FN14 antagonists and therapeutic uses thereof
    Patent number: 9238034
    Abstract: The present disclosure is directed to methods of using fibroblast growth factor-inducible 14 (Fn14) antagonists to modulate activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of Fn14. The present disclosure also provides pharmaceutical compositions comprising synergistic combinations Fn14 antagonists and chemotherapeutic agents.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: January 19, 2016
    Assignee: THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE
    Inventors: Nhan Tran, Nathalie Meurice, Harshil Dhruv
  • FN14 ANTAGONISTS AND THERAPEUTIC USES THEREOF
    Publication number: 20150017263
    Abstract: The present disclosure is directed to methods of using fibroblast growth factor-inducible 14 (Fn14) antagonists to modulate activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of Fn14. The present disclosure also provides pharmaceutical compositions comprising synergistic combinations Fn14 antagonists and chemotherapeutic agents.
    Type: Application
    Filed: July 9, 2014
    Publication date: January 15, 2015
    Inventors: Nhan Tran, Nathalie Meurice, Harshil Dhruv
  • Hydrophilic surface modification of polydimethylsiloxane
    Patent number: 8053548
    Abstract: A method for the preparation of hydrophilic elastomers involves the synthesis of polydimethylsiloxane with tunable hydrophilic surface properties. An elastomeric monolith with desired hydrophilic properties is produced by combining a polyethylene oxide polymeric surfactant additive with a PDMS base and curing agent during polymerization. The surfactant chain segment lengths are varied to control the hydrophobic/hydrophilic balance.
    Type: Grant
    Filed: September 1, 2009
    Date of Patent: November 8, 2011
    Assignee: Utah State University
    Inventors: Harshil Dhruv, David Britt
  • Hydrophilic Surface Modification of Polydimethylsiloxane
    Publication number: 20100063237
    Abstract: A method for the preparation of hydrophilic elastomers involves the synthesis of polydimethylsiloxane with tunable hydrophilic surface properties. An elastomeric monolith with desired hydrophilic properties is produced by combining a polyethylene oxide polymeric surfactant additive with a PDMS base and curing agent during polymerization. The surfactant chain segment lengths are varied to control the hydrophobic/hydrophilic balance.
    Type: Application
    Filed: September 1, 2009
    Publication date: March 11, 2010
    Applicant: Utah State University
    Inventors: Harshil Dhruv, David Britt