Abstract: A cocrystal complex of pirfenidone with a polyphenolic macrocycle host is disclosed. The composition is useful, in some embodiments, as an acne treatment. In one embodiment, the macrocycle is calixarene or a calixarene derivative. In another embodiment, the macrocycle is resorcin[4]arene. In one embodiment, the macrocycle is C-methylresorcin[4]arene (RsC1). In another embodiment, the macrocycle is C-butylresorcin[4]arene (RsC4).

Abstract: The present disclosure provides siloxane derivatives of amino acids that have surface-active properties. The amino acid can be naturally-occurring or synthetic, or they may be obtained via a ring-opening reaction of a lactam, such as caprolactam. The amino acid may be functionalized with a siloxane group to form a compound that is surface-active and has surfactant characteristics. The compounds have low critical micelle concentrations (CMC) as well as the ability to lower the surface tension of a liquid.

Abstract: A complex of curcumin with a polyphenolic macrocyclic host is disclosed. The macrocyclic host is a resorcin[4]arene. In one approach, the polyphenolic macrocyclic host is calix[8]arene. In another approach, the polyphenolic macrocyclic host is tert-butylcalix[8]arene.

Abstract: A one pot synthesis of a mixed macrocycle of resorcinol and pyrogallol is disclosed using an acidic catalyst by conventional as well as by microwave assisted methods. Compared with traditional synthesis, the microwave mediated tactic provides a simple, greener route and affords higher compound yields in a shorter period. Moreover, the catalyst can be efficiently reused without any loss in activity.

Abstract: A cocrystal complex of pirfenidone with a polyphenolic macrocycle host is disclosed. The composition is useful, in some embodiments, as an acne treatment. In one embodiment, the macrocycle is calixarene or a calixarene derivative. In another embodiment, the macrocycle is resorcin[4]arene. In one embodiment, the macrocycle is C-methylresorcin[4]arene (RsC1). In another embodiment, the macrocycle is C-butylresorcin[4]arene (RsC4).

Abstract: An aqueous antiperspirant composition comprising: 1) a metal salt with a M:X mole ratio from about 0.25 to 0.5, wherein X is an anion with a ?1 or ?2 charge and M is a metal ion with a +2, +3 or +4 charge; 2) an amino acid wherein the M:amino acid mole ratio is from about 5 to about 0.33; and 3) wherein the pH of the composition is from about 2 to about 4.

Abstract: The present invention involves the formation of host-guest complexes between C-methylresorcin[4]arene and Oxybenzone (OXB). NMR spectroscopy confirmed the formation of a weak host-guest complex and molecular dynamics docking simulations indicated that this complex likely had a 1:1 stoichiometry. Furthermore, skin permeation testing revealed that complexation by C-methylresorcin[4]arene significantly reduced the amount of OXB that permeated skin. These results show the potential of supramolecular complexation for improving the stability and decreasing the skin permeability of OXB, thus limiting harmful side effects.

Abstract: A novel composition is disclosed comprising the complex avobenzone-calix[8]-PO3H2. In another embodiment, the present invention is a sunscreen composition comprising the complex avobenzone-calix[8]-PO3H2 and a cosmetically acceptable carrier.

Abstract: A novel composition is disclosed comprising the complex avobenzone-calix[8]-PO3H2. In another embodiment, the present invention is a sunscreen composition comprising the complex avobenzone-calix[8]-PO3H2 and a cosmetically acceptable carrier.

Abstract: A one pot synthesis of a mixed macrocycle of resorcinol and pyrogallol is disclosed using an acidic catalyst by conventional as well as by microwave assisted methods. Compared with traditional synthesis, the microwave mediated tactic provides a simple, greener route and affords higher compound yields in a shorter period. Moreover, the catalyst can be efficiently reused without any loss in activity.