Patents by Inventor Hartmund Wollweber
Hartmund Wollweber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5955482Abstract: The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.Type: GrantFiled: March 28, 1997Date of Patent: September 21, 1999Assignee: Bayer AktiengesellschaftInventors: Klaus Urbahns, Otto Behner, Siegfried Goldmann, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Egbert Wehinger, Hartmund Wollweber, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de Vry
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Patent number: 5665741Abstract: The present invention relates to the use of 1,4-dihydropyridine-3,5-dicarboxylic acid esters, some of which are known, of the general formula (I) ##STR1## in which A and R.sup.1 -R.sup.3 have the meaning given in the description, as medicaments, in particular for treatment of the central nervous system, and new selected active compounds.Type: GrantFiled: August 18, 1995Date of Patent: September 9, 1997Assignee: Bayer AktiengesellschaftInventors: Klaus Urbahns, Otto Behner, Siegfried Goldmann, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Egbert Wehinger, Hartmund Wollweber, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor de Vry
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Patent number: 5652264Abstract: The cyclohexadiene derivatives are prepared by reaction of cyclohexanones with amines and subsequent dehydration. The compounds are effective in the treatment of depression on account of their property of being selective modulators of calcium channel-dependent potassium channels.Type: GrantFiled: March 27, 1996Date of Patent: July 29, 1997Assignee: Bayer AktiengesellschaftInventors: Klaus Urbahns, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Hartmund Wollweber, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor De Vry
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Patent number: 5559139Abstract: The invention relates to the new dimethyl 4-(4-chloro-3-trifluoromethylphenyl) -1-cyclopropyl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, a process for its preparation and its use as a medicament in ischaemic diseases which are associated with disorders of the microcirculation. This action can occur both in the peripheral and in the cerebral vascular system.Type: GrantFiled: July 13, 1993Date of Patent: September 24, 1996Assignee: Bayer AktiengesellschaftInventors: Otto Behner, Hartmund Wollweber, Bruno Rosen, Siegfried Zaiss, Siegfried Goldmann
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Patent number: 5530014Abstract: The cyclohexadiene derivatives are prepared by reaction of cyclohexanones with amines and subsequent dehydration. The compounds are suitable as active compounds in medicaments on account of their property of being selective modulators of calcium channel-dependent potassium channels.Type: GrantFiled: August 18, 1995Date of Patent: June 25, 1996Assignee: Bayer AktiengesellschaftInventors: Klaus Urbahns, Hans-Georg Heine, Bodo Junge, Rudolf Schohe-Loop, Hartmund Wollweber, Henning Sommermeyer, Thomas Glaser, Reilinde Wittka, Jean-Marie-Viktor De Vry
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Patent number: 5342847Abstract: The invention relates to the new dimethyl 2,6-dimethyl-1-n-propyl-4-(trifluoro-methylphenyl)-1,4-dihydropyridine-3-d icarboxylate, a process for its preparation and its use as a medicament in ischaemic diseases which are associated with disorders of the microcirculation. This action can occur both in the peripheral and in the cerebral vascular system.Type: GrantFiled: January 16, 1993Date of Patent: August 30, 1994Assignee: Bayer AktiengesellschaftInventors: Otto Behner, Hartmund Wollweber, Siegfried Goldmann, Bruno Rosen, Siegfried Zaiss
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Patent number: 5328931Abstract: N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be prepared either by reaction of aldehydes with acetoacetic esters and amines, optionally with isolation of the corresponding ylidene compounds, or by reaction of aminocrotonic acid esters with ylidene compounds and subsequent alkylation of the NH function. The N-alkylated 1,4-dihydropyridinedicarboxylic acid esters can be employed as active compounds in medicaments, in particular as cerebral therapeutics.Type: GrantFiled: July 21, 1992Date of Patent: July 12, 1994Assignee: Bayer AktiengesellschaftInventors: Bruno Rosen, Siegfried Zaiss, Hartmund Wollweber, Maarten de Jonge, Hans-Georg Dellweg
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Patent number: 4935409Abstract: Animal growth promoters of the formula ##STR1## The intermediates of the formula ##STR2## are also new.Type: GrantFiled: April 27, 1988Date of Patent: June 19, 1990Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Jurgen Stoltefuss, Friedrich Berschauer
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Patent number: 4904679Abstract: Pyrrolophenylalkanolamines of the formula ##STR1## R.sup.1 and R.sup.2 represent hydrogen or various radicals, R.sup.3 represents hydrogen, acyl or trialkylsilyl,R.sup.4 represents hydrogen or alkyl,R.sup.5 represents hydrogen, or, together with R.sup.3, represents ##STR2## wherein R.sup.7 represents hydrogen or alkyl, andR.sup.6 represents branched or cyfclic alkyl, which is optionally substituted,and salts thereof promote the yield of animals. Many new intermediates are also shown.Type: GrantFiled: April 22, 1988Date of Patent: February 27, 1990Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Jurgen Stoltefuss, Friedrich Berschauer, Ann de Jong, Martin Scheer
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Patent number: 4353913Abstract: The invention relates to 2-benzimidazolylcarbamic acid esters, substituted on the benzenoid nucleus by an aminoalkoxy, aminoalkylthio, an aminoalkylsulphinyl or an aminoalkylsulphonyl grouping. The invention also includes methods for making the compounds of the invention, compositions containing said compounds and the use of said compounds and compositions as anthelmintic agents.Type: GrantFiled: January 12, 1981Date of Patent: October 12, 1982Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Heinrich Kolling, Herbert Thomas, Peter Andrews
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Patent number: 4287199Abstract: The invention relates to 2-benzimidazolylcarbamic acid esters, substituted on the benzenoid nucleus by an aminoalkoxy, aminoalkylthio, an aminoalkylsulphinyl or an aminoalkylsulphonyl grouping. The invention also includes methods for making the compounds of the invention, compositions containing said compounds and the use of said compounds and compositions as anthelminitic agents.Type: GrantFiled: October 11, 1979Date of Patent: September 1, 1981Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Heinrich Kolling, Herbert Thomas, Peter Andrews
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Patent number: 4247546Abstract: The invention includes phosphonylureidobenzene compounds of the general formula ##STR1## or pharmaceutically acceptable salts in whichR.sup.1 and R.sup.2 are identical or different and represent an alkyl group, orR.sup.1 and R.sup.2 together represent a dimethylene group, a trimethylene group or a tetramethylene group,X and Y are identical or different and represent an oxygen atom or a sulphur atom andR.sup.3 and R.sup.4 are identical or different and represent an alkyl group, orR.sup.3 and R.sup.4 together represent a trimethylene group or a tetramethylene group, orR.sup.3 and R.sup.4, together with the carbon atom and nitrogen atom between them, form a thiazolidine ring system, which are used medicinally as parasiticides.The compounds are particularly effective in combatting helminths in carnivores.Type: GrantFiled: December 6, 1978Date of Patent: January 27, 1981Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Herbert Thomas, Peter Andrews
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Patent number: 4246260Abstract: The invention relates to new substituted o-phenylenediamine derivatives of the general formula ##STR1## in which R represents optionally substituted alkyl, optionally substituted alkenyl or optionally substituted alkinyl,X represents O, S, SO or SO.sub.2 andR.sup.1 and R.sup.2 are different from one another and individually represent ##STR2## in which R.sup.3 and R.sup.4 are identical or different and represent alkyl andR.sup.5 represents hydrogen, optionally substituted alkyl or optionally substituted alkoxy, and salts thereof.Also included in the invention are (1) methods for preparing the above-described compounds, (2) compositions containing the above-described compounds and (3) methods for the treatment of helminthiasis.Type: GrantFiled: March 19, 1979Date of Patent: January 20, 1981Assignee: Bayer AktiengesellschaftInventors: Heinrich Kolling, Ekkehard Niemers, Hartmund Wollweber, Herbert Thomas
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Patent number: 4194004Abstract: Novel substituted benzenesulphonic acid esters, particularly useful as anthelmintics are provided. The novel compounds are those of the general formula ##STR1## in which R represents hydrogen, optionally substituted alkyl, cyano, alkoxy, halogen, trifluoromethyl, amino, acylamino or nitro,X represents SO.sub.3 andR.sup.1 and R.sup.2 are different from one another and individually represent one of the radicals ##STR2## wherein Y represents S andR.sub.3 represents hydrogen, optionally substituted alkyl or alkoxy,and salts thereof. Also included in the invention are methods for preparing the novel compounds, compositions containing them and methods for the use of the compounds and compositions.Type: GrantFiled: November 2, 1977Date of Patent: March 18, 1980Assignee: Bayer AktiengesellschaftInventors: Ekkehard Niemers, Hartmund Wollweber, Heinrich Kolling, Herbert Thomas
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Patent number: 4127670Abstract: N-(2-formamidophenyl)-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(formamido)-phenyl group are anthelminetic agents. The compounds, of which N-(2-formamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoformanilide.Type: GrantFiled: February 22, 1977Date of Patent: November 28, 1978Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Heinrich Kolling, Herbert Thomas
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Patent number: 4088780Abstract: N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.Type: GrantFiled: May 26, 1976Date of Patent: May 9, 1978Assignee: Bayer AktiengesellschaftInventors: Heinrich Kolling, Herbert Thomas, Arno Widdig, Hartmund Wollweber
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Patent number: 4070494Abstract: Enteral pharmaceutical compositions containing medicinal agents having parenteral abuse potential are rendered resistant to aqueous extraction through the incorporation of a sufficient amount of a nontoxic, water gelable material. Attempts to extract the medicinal agent for parenteral abuse are thus inhibited or prevented since the material gels in the presence of water leaving no filterable liquid.Type: GrantFiled: December 15, 1975Date of Patent: January 24, 1978Assignee: Bayer AktiengesellschaftInventors: Friedrich Hoffmeister, Rudolf Hiltmann, Hartmund Wollweber, Helmut Kramer
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Patent number: 4064270Abstract: A new class of N'-(aminoacylaminophenyl) acetamidines: ##STR1## in which R.sup.1 and R.sup.2 are the same or different and represent hydrogen, alkyl, aryl or the substituted derivatives thereof or, together with the nitrogen atom to which they are attached, an heterocyclic ring; and R.sup.3 is hydrogen, alkyl, aryl, aralkyl, or a heterocyclic moiety including the substituted derivatives thereof. The products have utility as anthelmintics.The products are obtained by treating a suitable amino-acid or a carbonyl-activated amino-acid, with the appropriate N'-(4-aminophenyl)-N,N-dimethylacetamidine. In addition, the products are obtained by treating a suitable N'-(haloacylaminophenylacetamidine with an appropriate amine.Type: GrantFiled: September 13, 1974Date of Patent: December 20, 1977Assignee: Bayer AktiengesellschaftInventors: Hartmund Wollweber, Ekkehard Niemers, Hans Peter Schulz, Herbert Thomas, Peter Andrews
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Patent number: 4032655Abstract: N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.Type: GrantFiled: June 7, 1976Date of Patent: June 28, 1977Assignee: Bayer AktiengesellschaftInventors: Heinrich Kolling, Herbert Thomas, Arno Widdig, Hartmund Wollweber
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Patent number: 4024176Abstract: N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)-phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.Type: GrantFiled: May 26, 1976Date of Patent: May 17, 1977Assignee: Bayer AktiengesellschaftInventors: Heinrich Kolling, Herbert Thomas, Arno Widdig, Hartmund Wollweber