Abstract: Embodiments disclosed herein relate to methods for prolonging or regulating aspects of a subject's life or immunizing a subject. In particular, methods are provided for increasing or regulating longevity, survival time, life span, and health span comprising, administering to a subject in need of treatment an effective amount of at least one Cdc42-specific inhibitor. Additionally, methods are provided for immunizing a subject comprising, administering to a subject in need of immunization an effective amount of at least one Cdc42-specific inhibitor and administering to said subject one or more immunization dosages. Methods are described that further comprise identifying a subject as one that will benefit from increased longevity, increased survival time, increased life span, increased health span, or immunization. The subject is identified on the basis of the subject's age, the subject's present medical condition, the subject's present medical treatment, or the subject's Cdc42 activity.

Abstract: The present invention relates generally to methods and pharmaceutical compositions for rejuvenating hematopoietic stem cells and progenitor cells from blood, intestinal tissue and dermal tissue by administration of at least one inhibitor of a GT-Pase, such as Cdc42 GTPase.

Abstract: Some embodiments of the invention include methods for growing stem cells comprising growing the stem cells in a cell medium. In certain embodiments, the cell medium has a pH of from about 6.6 to about 7.2. Other embodiments of the invention embodiments include methods for transplanting comprising (a) growing first stem cells in a cell medium having a pH of from about 6.6 to about 7.2, to provide second stem cells and (b) transplanting the second stem cells into a recipient. Other embodiments include the methods where the stem cells that are human stem cells, mouse stem cells, rat stem cells, primate stem cells, or mammalian stem cells. Still other embodiments include growing stem cells in a cell medium having a pH of from about 6.6 to about 7.2 (e.g., from about 6.8 to about 7.0 or about 6.9) that results in modulation of one or more cell properties (e.g., decreased number of cells in the S phase, decreased amount of ROS, etc.) when that property is compared to that of stems cells grown at a pH of about 7.4.

Abstract: Methods of treating and preventing radiation injury are provided by the present invention. In particular, provided herein are methods comprising administering to a subject an Activated Protein C (APC), Plasma Zymogen Protein C (PC), or a variant thereof to treat or prevent radiation injury and to reduce chemical toxicity in subjects receiving myelosuppressive therapy.

Abstract: The present invention relates generally to methods and pharmaceutical compositions for rejuvenating hematopoietic stem cells and progenitor cells from blood, intestinal tissue and dermal tissue by administration of at least one inhibitor of a GT-Pase, such as Cdc42 GTPase.

Abstract: A therapeutic combination for improved mobilization of the hematopoietic stem and progenitor cells, and methods of use thereof are described. The therapeutic combination comprises G-CSF and an inhibitor of the EGFR signaling pathway. The role of EGFR is established by several lines of evidence, including use of quantitative trait locus analysis to map the chromosomal location of the non-G-CSF enhancement of hematopoietic stem and progenitor cells mobilization. Further, several different modes of inhibiting EGFR signaling all provide for an enhanced G-CSF induced mobilization of hematopoietic stem cells.

Abstract: A pneumatic suspension system for a vehicle includes pneumatic bellows connectable by means of a valve arrangement to at least one other component of the pneumatic suspension system in order to selectively increase or decrease the amount of compressed air therein. The other component contains at least one volume. Undesirable changes in the amount of compressed air inside the pneumatic bellows arising as a result of pressure compensation are avoided or reduced to a non-disruptive level by a return valve between the valve arrangement and the volume which prevents compressed air from flowing between the pneumatic bellows and the volume in one direction of flow.

Abstract: A pneumatic suspension system for a vehicle includes a compressed air accumulator, a compressed air transport device, at least one pneumatic bellows and an electrically controllable reversing valve used to connect the compressed air accumulator to a suction connection of the compressed air transport device, in order to increase the amount of air in the pneumatic bellows in a first switching position, and to connect an outlet connection of the compressed air transport device to the pneumatic bellows, also used to connect the pneumatic bellows to the suction connection of the compressed air transport device and the outlet connection of the compressed air transport device to the pressure accumulator in a second switching position in order to reduce the amount of air in the pneumatic bellows. The reversing valve can be pre-controlled with the compressed air of the pneumatic suspension system.

Abstract: A pneumatic suspension system for a vehicle includes a compressed air accumulator, a compressed air transport device, at least one pneumatic bellows and an electrically controllable reversing valve used to connect the compressed air accumulator to a suction connection of the compressed air transport device, in order to increase the amount of air in the pneumatic bellows in a first switching position, and to connect an outlet connection of the compressed air transport device to the pneumatic bellows also used to connect the pneumatic bellows to the suction connection of the compressed air transport device and the outlet connection of the compressed air transport device to the pressure accumulators in a second switching position in order to reduce the amount of air in the pneumatic bellows. The reversing valve can be pre-controlled with the compressed air of the pneumatic suspension system.

Abstract: A pneumatic suspension system for a vehicle includes pneumatic bellows connectable by means of a valve arrangement to at least one other component of the pneumatic suspension system in order to selectively increase or decrease the amount of compressed air therein. The other component contains at least one volume. Undesirable changes in the amount of compressed air inside the pneumatic bellows arising as a result of pressure compensation are avoided or reduced to a non-disruptive level a return valve between the valve arrangement and the volume which prevents compressed air from flowing between the pneumatic bellows and the volume in one direction of flow.

Abstract: A pneumatic spring system for a vehicle embodied as a partially closed system wherein air can be suctioned from the atmosphere and/or air can be dispersed into the atmosphere, as required. The pneumatic spring system includes a first component connected to the atmosphere. The first component is used exclusively for suctioning air from the atmosphere. A second component connected to the atmosphere is used exclusively for dispersing compressed-air into the atmosphere.

Abstract: A pressure-tight contact device, especially for use in a pressure-tight encapsulated motor of a compressor. The contact device includes a connector shell, which can be pressed onto an insulator and is fastened to the pressure-tight housing enclosing the motor. The motor is connected by means of electrical connecting leads to at least one contact pin. The pin passes through the insulator and a punched opening of a contact tab for connection to a connecting cable. The individual parts of the contact device are sealed relative to one another by means of O-rings. The connector shell has a shroud member which can be formed in various configurations desired by the user for connection to various types of connecting cables.

Abstract: A pressure fluid operated ride leveler which adjusts the actual level of a vehicle body relative to a vehicle axle to a desired level, includes a pressure fluid source and a pressure fluid sink, pressure fluid chambers which support the vehicle body, and a pressure fluid conduit connecting the pressure fluid chambers to either the pressure fluid source or the pressure fluid sink. First and second controllable valve mechanisms are disposed in the pressure fluid conduit. The second valve mechanism is, e.g., a controllable throttling valve, capable of reducing the diameter of the pressure fluid conduit. Both the first and second valve mechanisms are actuated by a control unit. The control unit actuates the first valve mechanism to connect the chambers to the pressure fluid source or the pressure fluid sink based on the difference between the actual level of the vehicle body and the desired level.

Abstract: The inventive device controls the trailing axle of a vehicle having at least two rear axles, wherein at least one rear axle is a driving axle. Pressure fluid chambers, mounted on both the driving and trailing axles, support the vehicle structure. Their pressure is varied to raise or lower the vehicle structure depending on the vehicle load and road conditions. The inventive device further comprises a first valve arrangement and a second valve arrangement. The first valve arrangement selectively connects the pressure fluid chambers of the driving axle to a compressed-air supply, to a pressure fluid sink, or isolates them. The first valve arrangement has a first and a second valve. The first valve is a 3/2-position valve actuated by a first solenoid. The second valve of the first valve arrangement is a 2/2-position valve actuated by a second solenoid. The second valve arrangement is a 3-position valve actuated by a third solenoid.

Abstract: A device for changing the pressure in tires of a motor vehicle. The novel device achieves that the venting of the tires can be performed independent of throttling. The device includes a tire-pressure control valve (1) with a pneumatic connection terminal (8). A control element (10) is chargeable via the pneumatic connection terminal (8). The control element (10) is formed as an actuating piston, for actuation of the valve device, comprised of valve seat (5) and closure body (6), against a restoring force, furnished by a valve spring (7), into the open position by the pressure of the compressed-air source. The device can be retrofitted into the conventional tire-pressure control device systems.