Patents by Inventor Hartmut Osswald
Hartmut Osswald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6395256Abstract: The invention relates to a method for detecting adenosine with the inactive S-adenosyl homocysteine hydrolase's enzyme which selectively and only binds adenosine with high affinity. The inventive method enables adenosine to be determined in small sample volumes without the need for additional purification of said sample.Type: GrantFiled: June 21, 2000Date of Patent: May 28, 2002Inventors: Hartmut Osswald, Doris Kloor
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Patent number: 5516915Abstract: The present invention provides bis-(1H-indol-3-yl)maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds, and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, of inflammatory processes, allergies, cancer, and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases.Type: GrantFiled: September 12, 1994Date of Patent: May 14, 1996Assignee: Goedecke AktiengesellschaftInventors: Hubert Barth, Johannes Hartenstein, Claus Rudolph, Christoph Schachtele, Hans-Jurgen Betche, Reinhard Reck, Hartmut Osswald
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Patent number: 5438050Abstract: New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the inhibition of protein kinases, such as protein kinase C, for the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension, or for inflammatory processes, allergies, cancers, viral diseases, and certain degenerative damages of the central nervous system are disclosed.Type: GrantFiled: January 21, 1994Date of Patent: August 1, 1995Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Johannes Hartenstein, Hubert Barth, Christoph Schachtele, Claus Rudolph, Gunter Weinheimer, Hartmut Osswald
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Patent number: 5401875Abstract: The invention concerns 2-aminocarboxylic acids and derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing them for the inhibition of protein kinase C and thus for the prevention and/or treatment of heart and blood vessel diseases, such as thromboses, arterioscleroses, hypertension, of inflammatory processes, allergies, cancers, and certain degenerative damages of the central nervous system.Type: GrantFiled: April 22, 1991Date of Patent: March 28, 1995Assignee: Godecke AktiengesellschaftInventors: Uwe Trostmann, Johannes Hartenstein, Claus Rudolph, Christoph Schachtele, Hartmut Osswald, Gunter Weinheimer
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Patent number: 5380746Abstract: The present invention provides bis-(1H-indol-3-yl)maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds, and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, of inflammatory processes, allergies, cancer, and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases.Type: GrantFiled: March 9, 1993Date of Patent: January 10, 1995Assignee: Goedecke AktiengesellschaftInventors: Hubert Barth, Johannes Hartenstein, Claus Rudolph, Christoph Schachtele, Hans-Jurgen Betche, Reinhard Reck, Hartmut Osswald
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Patent number: 5322844Abstract: The invention concerns new derivatives of certain alkoxy-4(1H)-pyridones, processes for preparing them, and pharmaceutical compositions containing them. The compounds of the invention are useful in the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arteriosclerosis and hypertension, and of inflammatory processes, allergies, cancers, and certain degenerative damage of the central nervous system.Type: GrantFiled: October 7, 1992Date of Patent: June 21, 1994Assignee: Godecke AktiengesellschaftInventors: Julian Aranda, Johannes Hartenstein, Reinhard Reck, Christoph Schachtele, Claus Rudolph, Hartmut Osswald, Gunter Weinheimer
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Patent number: 5185352Abstract: The invention concerns new derivatives of certain alkoxy -4(1H)-pyridones, processes for preparing them, and pharmaceutical compositions containing them. The compounds of the invention are useful in the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arteriosclerosis and hypertension, and of inflammatory processes, allergies, cancers, and certain degenerative damage of the central nervous system.Type: GrantFiled: January 28, 1991Date of Patent: February 9, 1993Assignee: Goedecke AktiengesellschaftInventors: Julian Aranda, Johannes Hartenstein, Reinhard Reck, Christopher Schachtele, Claus Rudolph, Hartmut Osswald, Gunter Weinheimer
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Patent number: 5034382Abstract: The invention is concerned with the application of adenosine in the form of topically applicable pharmaceutical preparations for controlling herpes, in particular herpes labialis, herpes zoster, and herpes genitalis. The preparations are applied thinly several times daily to the affected skin or mucous areas. The active substance concentration should be in the region of 5-30%. Anhydrous preparations such as powder or anhydrous ointments have proven to be particularly effective and are surprisingly rapid in promoting healing.Type: GrantFiled: May 25, 1989Date of Patent: July 23, 1991Assignee: Goedecke A.G.Inventor: Hartmut Osswald
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Patent number: 4762837Abstract: 4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation.For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arterioschlerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.Type: GrantFiled: May 29, 1987Date of Patent: August 9, 1988Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
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Patent number: 4760081Abstract: The present invention describes 1,6-naphthyridine derivatives of the general formula: ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromatic or heteroaromatic ring, R.sup.2 is a straight-chained or branched alkyl radical containing up to four carbon atoms or a benzyl radical, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radicals or an alkoxycarbonyl radical containing up to four carbon atoms, R.sup.4 is a straight-chained or branched alkyl radical containing up to four carbons and R.sup.5 is a carboxyl group or a straight-chained, branched or cyclic alkoxycarbonyl radical which contains up to 17 carbon atoms and optionally also contains an oxygen, sulphur or nitrogen atom; as well as the pharmacologically acceptable salts thereof, which are useful for treating diseases of the blood vessels.Type: GrantFiled: January 28, 1987Date of Patent: July 26, 1988Assignee: Goedecke AktiengesellschaftInventors: Gerhard Satzinger, Johannes Hartenstein, Karl Mannhardt, Jurgen Kleinschroth, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
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Patent number: 4751228Abstract: The present invention provides 1,6-naphthyridine derivatives of formula ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromatic or heteroaromatic ring or an unsubstituted or substituted condensed aromatic or heterocyclic ring system, R.sup.2 is a straight-chained or branched alkyl radical containing up to 4 carbon atoms, a benzyl radical or a straight-chained or branched, substituted or unsubstituted aminoalkyl radical containing up to 8 carbon atoms, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radical or an alkoxycarbonyl radical, in each case containing up to 4 carbon atoms, R.sup.4 is a straight-chained or branched hydrocarbon radical containing up to 21 carbon atoms, which can also contain oxygen, sulphur, nitrogen or halogen atoms and is optionally substituted by carbocyclic or heterocyclic ring systems, or is an amino, cyano, formyl, halogenomethyl or dihalomethyl radical and R.sup.Type: GrantFiled: January 28, 1987Date of Patent: June 14, 1988Assignee: Goedecke AktiengesellschaftInventors: Jorgen Kleinschroth, Karl Mannhardt, Johannes Hartenstein, Gerhard Satzinger, Dieter Muster, Wolfgang Steinbrecher, Bernd Wagner, Hartmut Osswald
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Patent number: 4724266Abstract: The present invention provides combination of materials for strengthening the antithrombotic action of acetylsalicylic acid. It covers a composition which contains diltiazem or a pharmaceutically acceptable acid-addition salt thereof in combination with acetylsalicylic acid. It also forms the new compound diltiazem acetysalicylate. It also covers compositions containing the above and methods for using the compositions or compound.Type: GrantFiled: July 21, 1987Date of Patent: February 9, 1988Assignee: Godecke AktiengesellschaftInventors: Gerhard Satzinger, Gunter Wolf, Hartmut Osswald, Ute Weiershausen
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Patent number: 4711901Abstract: The present invention describes 1,6-naphthyridine derivatives of the general formula: ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromtic or heteroaromatic ring, R.sup.2 is a straight-chained or branched alkyl radical containing up to four carbon atoms or a benzyl radical, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radical or an alkoxycarbonyl radical containing up to four carbon atoms, R.sup.4 is a straight-chained or branched alkyl radical containing up to four carbons and R.sup.5 is a carbonyl group or a straight-chained, branched or cyclic alkoxycarbonyl radical which contains up to 17 carbon atoms and optionally also contains an oxygen, sulphur or nitrogen atom; as well as the pharamacologically acceptable salts thereof, which are useful for treating diseases of the blood vessels.Type: GrantFiled: July 30, 1986Date of Patent: December 8, 1987Inventors: Gerhard Satzinger, Johannes Hartenstein, Karl Mannhardt, Jurgen Kleinschroth, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
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Patent number: 4681882Abstract: 4-Alkoxy-pyrido[2,3-d]pyrimidine derivatives are described as well as processes for their preparation.For reason of their vasospasmolytic effects these compounds are mainly indicated for the treatment of cerebral, cardiac, and peripheral vascular diseases such as myocardiac ischemia, cerebral infarction, pulmonary thromboses, as well as in cases of arteriosclerosis and other stenotic disorders. They are therefore valuable agents for combating cardiovascular mortality.Type: GrantFiled: October 16, 1985Date of Patent: July 21, 1987Assignee: Godecke AktiengesellschaftInventors: Jorgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gonter Weinheimer, Edgar Fritschi
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Patent number: 4681881Abstract: The invention concerns new 5-alkoxy-pyrido[4,3-d]pyrimidine derivatives and pharmacologically acceptable salts thereof, as well as a chemically novel process for their preparation. The new compounds are used in the control of cerebral, cardiac or peripheral vascular diseases or of stenotic symptoms.Type: GrantFiled: January 21, 1986Date of Patent: July 21, 1987Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Bernd Wagner
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Patent number: 4681885Abstract: The invention concerns new 5-oxo-pyrido[4,3-d]pyrimidine derivatives and the pharmacologically acceptable salts thereof, as well as a chemically novel process for the preparation of the new compounds and their use in the control of cerebral, cardiac, or peripheral vascular diseases or of stenotic symptoms.Type: GrantFiled: January 21, 1986Date of Patent: July 21, 1987Assignee: Godecke AktiengesellschaftInventors: Jurgen Kleinschroth, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Bernd Wagner
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Patent number: 4677108Abstract: 4-Oxo-pyrido[2,3-d]pyrimidine derivatives are herein described as well as processes for their preparation.These compounds possess valuable pharmacological properties. As calcium antagonists they exert vasospasmolytic, vasodilatory, and antihypertensive activities. Surprisingly some of the compounds also have the effect of increasing contractility. They are therefore particularly suited for the treatment of vascular diseases.Type: GrantFiled: October 16, 1985Date of Patent: June 30, 1987Assignee: Warner-Lambert CompanyInventors: Jurgen Kleinschroth, Gerhard Satzinger, Karl Mannhardt, Johannes Hartenstein, Hartmut Osswald, Gunter Weinheimer, Edgar Fritschi
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Patent number: 4612311Abstract: 1,2,4-Benzothiadiazine oxide derivatives of the general Formula I ##STR1## in which R.sup.1 represents an unsubstituted or substituted aryl radical;R.sup.2 and R.sup.5, which may be the same or different, and represent hydrogen, halogen, or a nitro group, andR.sup.3 represents a hydrogen atom or a hydroxy radical, an alkyl, alkoxy alkyl or alkoxy carbonyl radical with up to four carbon atoms, unsubstituted or substituted by halogen, hydroxy, amino, alkyl amino or dialkyl amino radicals, or a phenyl radical, unsubstituted or substituted by halogen,are described as having anxiolytic effects on the central nervous system.Type: GrantFiled: September 4, 1985Date of Patent: September 16, 1986Assignee: Warner-Lambert CompanyInventors: Hubert Barth, Johannes Hartenstein, Gerhard Satzinger, Edgar Fritschi, Hartmut Osswald, Gerd Bartoszyk