Patents by Inventor Hartmut Schurig

Hartmut Schurig has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD FOR PURIFYING PEGylated ERYTHROPOIETIN
    Publication number: 20210094993
    Abstract: Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange SP Sephacryi™ S 500 HR chromatography material conditioned to a conductivity of 21 mS/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield.
    Type: Application
    Filed: September 17, 2020
    Publication date: April 1, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Roberto FALKENSTEIN, Wolfgang KOEHNLEIN, Wolfgang KUHNE, Hartmut SCHURIG
  • Method for purifying PEGylated erythropoietin
    Patent number: 10273277
    Abstract: Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange SP Sephacryl™ S 500 HR chromatography material conditioned to a conductivity of 21 mS/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield.
    Type: Grant
    Filed: February 19, 2016
    Date of Patent: April 30, 2019
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roberto Falkenstein, Wolfgang Koehnlein, Wolfgang Kuhne, Hartmut Schurig
  • METHOD FOR PURIFYING PEGylated ERYTHROPOIETIN
    Publication number: 20170008941
    Abstract: Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange SP Sephacryl™ S 500 HR chromatography material conditioned to a conductivity of 21 mS/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield.
    Type: Application
    Filed: February 19, 2016
    Publication date: January 12, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Roberto Falkenstein, Wolfgang Koehnlein, Wolfgang Kuhne, Hartmut Schurig
  • Purification of pegylated polypeptides
    Patent number: 8889837
    Abstract: The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: November 18, 2014
    Assignee: Hoffman-La Roche Inc.
    Inventors: Josef Burg, Klaus Reichert, Axel Schroth, Hartmut Schurig, Axel Wessner
  • Chromatographic methods
    Patent number: 8795533
    Abstract: The current invention comprises a method for the regeneration of a cation exchange chromatography column.
    Type: Grant
    Filed: October 26, 2010
    Date of Patent: August 5, 2014
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Josef Burg, Klaus Reichert, Axel Schroth, Hartmut Schurig, Axel Wessner
  • METHOD FOR PURIFYING PEGylated ERYTHROPOIETIN
    Publication number: 20140163207
    Abstract: Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange SP Sephacryl™ S 500 HR chromatography material conditioned to a conductivity of 21 mS/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield.
    Type: Application
    Filed: November 26, 2013
    Publication date: June 12, 2014
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Roberto Falkenstein, Wolfgang Koehnlein, Wolfgang Kuhne, Hartmut Schurig (deceased)
  • METHOD FOR PURIFYING PEGylated ERYTHROPOIETIN
    Publication number: 20120197007
    Abstract: Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly(ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange SP Sephacryl™ S 500 HR chromatography material conditioned to a conductivity of 21 mS/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly(ethylene glycol) residue can be obtained in a single step with high purity and yield.
    Type: Application
    Filed: September 14, 2011
    Publication date: August 2, 2012
    Inventors: Roberto Falkenstein, Wolfgang Koehnlein, Wolfgang Kuhne, Hartmut Schurig, Sibylle Schurig
  • Purification of pegylated polypeptides
    Patent number: 8138317
    Abstract: The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: March 20, 2012
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Josef Burg, Klaus Reichert, Axel Schroth, Hartmut Schurig, Axel Wessner
  • Purification of pegylated polypeptides
    Publication number: 20110118448
    Abstract: The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.
    Type: Application
    Filed: January 24, 2011
    Publication date: May 19, 2011
    Inventors: Josef Burg, Klaus Reichert, Axel Schroth, Hartmut Schurig, Axel Wessner
  • Chromatographic methods
    Publication number: 20110065903
    Abstract: The current invention comprises a method for the regeneration of a cation exchange chromatography column.
    Type: Application
    Filed: October 26, 2010
    Publication date: March 17, 2011
    Inventors: Josef Burg, Klaus Reichert, Axel Schroth, Hartmut Schurig, Axel Wessner
  • Chromatographic methods
    Patent number: 7846336
    Abstract: The current invention comprises a method for the regeneration of a cation exchange chromatography column.
    Type: Grant
    Filed: July 16, 2008
    Date of Patent: December 7, 2010
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Josef Burg, Klaus Reichert, Axel Schroth, Hartmut Schurig, Axel Wessner
  • Purification of pegylated polypeptides
    Publication number: 20090118476
    Abstract: The invention is a method for the purification of mono-PEGylated erythropoietin using two cation exchange chromatography steps wherein the same type of cation exchange material is used in both cation exchange chromatography steps and a method for producing a mono-PEGylated erythropoietin in substantially homogeneous form.
    Type: Application
    Filed: July 16, 2008
    Publication date: May 7, 2009
    Inventors: Josef Burg, Klaus Reichert, Axel Schroth, Hartmut Schurig, Axel Wessner
  • Chromatographic methods
    Publication number: 20090101585
    Abstract: The current invention comprises a method for the regeneration of a cation exchange chromatography column.
    Type: Application
    Filed: July 16, 2008
    Publication date: April 23, 2009
    Inventors: Josef Burg, Klaus Reichert, Axel Schroth, Hartmut Schurig, Axel Wessner