Abstract: The invention relates to a composite system comprising at least one biodegradable blend, containing at least one biodegradable block copolyester urethane (PEU) and also at least one polyhydroxyalkanoate (PHA), possibly a filler comprising a polysaccharide and/or derivatives thereof and also possibly further biocompatible additives. Composite systems of this type are used for producing molded articles, molded parts or extrudates. Furthermore, the invention relates to possibilities for using the composite system.

Abstract: The invention relates to a composite system comprising at least one biodegradable blend, containing at least one biodegradable block copolyester urethane (PEU) and also at least one polyhydroxyalkanoate (PHA), possibly a filler comprising a polysaccharide and/or derivatives thereof and also possibly further biocompatible additives. Composite systems of this type are used for producing moulded articles, moulded parts or extrudates. Furthermore, the invention relates to possibilities for using the composite system.

Abstract: The invention relates to a composite system comprising at least one biodegradable block copolyester urethane, at least one filler comprising a polysaccharide and/or derivatives thereof and also possibly further biocompatible additives. Composite systems of this type are used for the production of moulded articles, moulded parts or extrudates. In addition, the invention relates to a method for the production of a biodegradable block copolyester urethane by polyaddition of a polyhydroxy alkanoate diol, a polyester diol of a dicarboxylic acid monoester and a bifunctional isocyanate.

Abstract: The present invention relates to dithiolane derivatives of formula A, to conjugates of the dithiolane derivatives with organochemical or biochemical molecules, to processes for the preparation of the dithiolane derivatives and to the conjugates, to a coated noble metal or semiconductor structure comprising a noble-metal-coated substrate or a semiconductor carrier and a dithiolane derivative immobilised thereon or a conjugate according to the invention, to a biochip containing the noble metal or semiconductor structure according to the invention, and to the use of the dithiolane derivatives according to the invention for immobilising organochemical or biochemical molecules on noble metals, noble metal alloys or semiconductors.

Abstract: The invention relates to a device and to a process for the automatic synthesis of macromolecules on a tape-like substrate material (11). The device has at least one synthesis module (12) which can be sealed from the outside and comprises reaction chambers (15) and fluid lines (18, 19) for filling and emptying the reaction chambers (15) with and of reaction media, it being possible to introduce the substrate material (11) into the synthesis module (12) and bring it into contact with the reaction chambers (15). Transport means (20-26) which are intended to move the substrate material (11) through a particular distance and can be actuated by a control device are furthermore provided. The invention also relates to the use of such a device for the synthesis of oligonucleotides bound on a functionalized substrate material, in particular the production of oligonucleotide libraries.

Abstract: The invention relates to oligoribonucleotide analogs with terminal 3′—3′ and/or 5′—5′ internucleotide linkages. This modification stabilizes the molecules altered in this way, including ribozymes, without adversely altering their properties, including, where appropriate, catalytic activities.

Abstract: The invention relates to a device and to a process for the automatic synthesis of macromolecules on a tape-like substrate material (11). The device has at least one synthesis module (12) which can be sealed from the outside and comprises reaction chambers (15) and fluid lines (18, 19) for filling and emptying the reaction chambers (15) with and of reaction media, it being possible to introduce the substrate material (11) into the synthesis module (12) and bring it into contact with the reaction chambers (15). Transport means (20-26) which are intended to move the substrate material (11) through a particular distance and can be actuated by a control device are furthermore provided. The invention also relates to the use of such a device for the synthesis of oligonucleotides bound on a functionalized substrate material, in particular the production of oligonucleotide libraries.

Abstract: The present invention concerns biodegradable linear polyester urethanes as well as biodegradable crosslinked polyester urethanes issuing from the linear polyester urethanes in such a way that they are crosslinked by diisocyanate bridges. By varying the degree of crosslinking it is possible to adjust the physical, chemical and biological properties in the crosslinked polyester urethane as defined by the invention in a targeted manner. In particular, it is possible to vary the rate of biodegradation of said crosslinked polyester urethane because the biological degradation takes place at a slower rate as the degree of crosslinking increases. Furthermore, the object of the invention is a method of producing the polyester urethanes as defined by the invention, as well as its application in the form of sheets or foils, shaped rubber articles, containers, packaging materials, in the field of galenic pharmacy; and in the form of adhesives and adhesive tapes and the like.

Abstract: Provision is made, in a device and a process for the synthesis of macromolecules, for reagent solutions to be conveyed through reaction channels (15) which are connected to one another by intermediate channels (16, 17) and are preferably aligned parallel to one another, the reaction channels (15) being so displaced between individual synthesis steps relative to the carrier material acted on by the reagent solutions that, in the new position, the reaction channels (15) cover different synthesis zones from those in the previous position. In that manner provision is made for the synthesis of a large number of different sequences by relatively few synthesis steps.

Abstract: The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.

Abstract: The invention relates to a liquid crystalline, photo cross-linkable main-chain polymer used as interferentially effective, chromophoric substance for colored paints, in which the main mesogenic groups are disposed at least approximately in a chiral-nematic manner. An etherified cellulose ether or a mixture of several etherified cellulose ethers is used pursuant to the invention as liquid crystalline main-chain polymer or polymers wherein:the cellulose ethers have a molecular weight of 500 to 1,000,000,the anhydroglucose units of the cellulose ethers are etherified with an average degree of molar substitution of 2 to 7 with propylene oxide or ethylene oxide units (C.sub.3 H.sub.6 O- or C.sub.2 H.sub.4 O-units), andthe cellulose ethers are etherified with an average degree of molar substitution of 1.5 to 3 with unsaturated hydrocarbon groups (C.sub.r H.sub.2r-1).

Abstract: Therapeutically utilizable oligonucleotides of the formulae I and II have been obtained by introduction of terminal 3'--3' and 5'--5' linkages. These compounds are stable to nucleases and suppress the biological function of nucleic acids.

Abstract: The subject matter of the invention is a modified phosphoramidite process for the synthesis of nucleotide sequences. By use of a modified nucleoside phosphoramidite it is possible to produce nucleotide sequences which have a modified phosphate residue.

Abstract: The synthesis and use of polymeric carriers is described which are loaded with nucleic acid building blocks which in turn contain labelling groups or precursors thereof. The polymeric carrier loaded in this way serves as a solid or liquid phase for the assembly of oligonucleotides which can be used as primers for template-dependent enzymatic nucleic acid syntheses such as for example in sequencing analysis according to Sanger and co-workers or in the polymerase chain reaction (PCR).

Abstract: A process for cleavage of a protein (a) sequence from a protein containing the tetrapeptide sequence Pro-Xyz-Gly-Pro, wherein Xyz can be any desired amino acid, and reacting the protein with a collagenase whereby the Xyz-Gly bond is selectively cleaved, thereby producing a protein with the sequence Gly-Pro at its N-terminal end; or (b) containing the sequence Met-Pro; and subsequently selectively cleaving the glycine or methionine residue from the N-terminal end of the product protein with an aminoacylproline aminopeptidase and selectively cleaving the proline residue therefrom with a proline aminopeptidase; or subsequently selectively cleaving the Gly-Pro or Met-Pro residue from the N-terminal end of the produced protein using a postproline dipeptidylaminopeptidase.

Abstract: A tridecadeoxynucleotide of the formuladCCTTCTGGAACTG,is useful as a primer in the enzymatic synthesis of deoxyribonucleic acid (DNA) on messenger ribonucleic acid (mRNA) matrices.The new tridecadeoxynucleotide is obtained by linking suitable partially protected oligonucleotide blocks, particularly two suitable oligonucleotide fragments, e.g. by linking a suitable tetramer to a suitable nomaer, using a condensing agent.