Abstract: The present disclosure provides methods of treatment using ophthalmic compositions comprising semifluorinated alkanes for keratoconjunctivitis sicca and/or Meibomian gland dysfunction, which methods provide for the enrichment of an ophthalmic tissue in the semifluorinated alkane, and optionally methods of delayed release of the semifluorinated alkane from the enriched ophthalmic tissue to the surface of the cornea and/or conjunctiva, and/or to the Meibomian gland.

Abstract: The invention provides pharmaceutical compositions comprising about 0.05 to 0.1% (w/v) cyclosporine dissolved in 1-perfluorobutyl-pentane for use in the topical treatment of dry eye disease and provides for dosing and treatment methods thereof. The invention further provides kits comprising such compositions.

Abstract: The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.

Abstract: A device is provided for injecting an emulsion of water and fuel into an internal combustion engine of a motor vehicle. The device includes a water tank (100) for storing water, a fuel tank (101) for storing fuel, first and second fluid lines (103), an emulsion mixer having a mixing chamber (102), first and second inlets (104), and an outlet (105). The water tank (100) is connected to the first inlet (104) via the first fluid line (103). The fuel tank (101) is connected to the second inlet (104) via the second fluid line (103). The emulsion mixer is configured to output an emulsion that comprises the fuel and the water via the outlet (105). A settable mixer is in the mixing chamber (102) and is configured to set a mixture ratio between the water and the fuel in the emulsion.

Abstract: The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.

Abstract: The present invention is directed to certain semifluorinated compounds and to compositions comprising such compounds. The invention further provides the use of the compounds and of the compositions as medicaments for topical administration to the eye.

Abstract: The present invention is directed to certain semifluorinated compounds and to compositions comprising such compounds. The invention further provides the use of the compounds and of the compositions as medicaments for topical administration to the eye.

Abstract: A collecting pressure line (1) for a fuel injection system of an internal combustion engine has a flow-traversable interior (9). The collecting pressure line (1) has at least one injector that is flow-traversable with the aid of a throughflow opening (8). Fluid present in the collecting pressure line (1) is injected with the aid of the injector into a combustion chamber of the internal combustion engine. An elastic member (10) is formed in the interior (9) and is designed to be flow-traversable while bearing against a line inner wall (15) and spaced apart from the throughflow opening (8).

Abstract: A fuel injection system (4) for an internal combustion engine has a low-pressure pump for delivering fuel from a fuel tank. The fuel is fed upstream of an injector (11) of the fuel injection system (4) to a mixing device (14). The mixing device (14) has a mixer housing (18) with a fuel connection (15) for receiving fuel and with at least one coolant connection (17; 28; 33) for receiving a coolant. For the purpose of bringing about efficient mixing of the fuel and the coolant, before a collision of a fuel jet (40) of the fuel and a coolant jet (41) of the coolant, the two fluid jets (40, 41) are formed to be at least partially aligned in the same direction.

Abstract: The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.

Abstract: The present disclosure provides methods of treatment using ophthalmic compositions comprising semifluorinated alkanes for keratoconjunctivitis sicca and/or Meibomian gland dysfunction, which methods provide for the enrichment of an ophthalmic tissue in the semifluorinated alkane, and optionally methods of delayed release of the semifluorinated alkane from the enriched ophthalmic tissue to the surface of the cornea and/or conjunctiva, and/or to the Meibomian gland.

Abstract: A collecting pressure line (1) for a fuel injection system of an internal combustion engine has a flow-traversable interior (9). The collecting pressure line (1) has at least one injector that is flow-traversable with the aid of a throughflow opening (8). Fluid present in the collecting pressure line (1) is injected with the aid of the injector into a combustion chamber of the internal combustion engine. An elastic member (10) is formed in the interior (9) and is designed to be flow-traversable while bearing against a line inner wall (15) and spaced apart from the throughflow opening (8).

Abstract: A device is provided for injecting an emulsion of water and fuel into an internal combustion engine of a motor vehicle. The device includes a water tank (100) for storing water, a fuel tank (101) for storing fuel, first and second fluid lines (103), an emulsion mixer having a mixing chamber (102), first and second inlets (104), and an outlet (105). The water tank (100) is connected to the first inlet (104) via the first fluid line (103). The fuel tank (101) is connected to the second inlet (104) via the second fluid line (103). The emulsion mixer is configured to output an emulsion that comprises the fuel and the water via the outlet (105). A settable mixer is in the mixing chamber (102) and is configured to set a mixture ratio between the water and the fuel in the emulsion.

Abstract: The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.

Abstract: A fuel injection system (4) for an internal combustion engine has a low-pressure pump for delivering fuel from a fuel tank. The fuel is fed upstream of an injector (11) of the fuel injection system (4) to a mixing device (14). The mixing device (14) has a mixer housing (18) with a fuel connection (15) for receiving fuel and with at least one coolant connection (17; 28; 33) for receiving a coolant. For the purpose of bringing about efficient mixing of the fuel and the coolant, before a collision of a fuel jet (40) of the fuel and a coolant jet (41) of the coolant, the two fluid jets (40, 41) are formed to be at least partially aligned in the same direction.

Abstract: The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.

Abstract: The invention provides pharmaceutical compositions comprising about 0.05 to 0.1% (w/v) cyclosporine dissolved in 1-perfluorobutyl-pentane for use in the topical treatment of dry eye disease and provides for dosing and treatment methods thereof. The invention further provides kits comprising such compositions.

Abstract: There is disclosed a molecular composition(s) of a novel tissue protective erythropoietin (EPO) binding receptor protein complex, termed NEPOR. Presence of NEPOR components on a tumour allows EPO to impinge on the survival of associated cells thereby enhancing tumour progression and negatively effecting patient survival. Presence of NEPOR represents a prognostic biomarker for poorer patient outcome. Thus, methods are provided for stratifying patients having a tumour as suitable (i.e. NEPOR not present) or non-suitable (i.e., NEPOR present) for EPO treatment, comprising: (a) isolating a tissue sample from an individual who is receiving or is a candidate for receiving erythropoietin, (b) determining the level of expression of the NEPOR gene(s) (mRNA) and/or the presence of the NEPOR gene product (protein) from the isolated tissue, and (c) correlating the presence of an NEPOR gene expression product or the presence of NEPOR protein to a physiological response to the treatment with erythropoietin.

Abstract: The present invention is directed to certain semifluorinated compounds and to compositions comprising such compounds. The invention further provides the use of the compounds and of the compositions as medicaments for topical administration to the eye.

Abstract: The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.