Patents by Inventor Hartmuth Christian Kolb

Hartmuth Christian Kolb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220018857
    Abstract: A method for detecting p217+tau in blood-based samples from a subject with high sensitivity, accuracy, and precision. The assay comprises contacting a sample with a capture antibody directed against a p217+tau epitope to bind the capture antibody to p217+tau peptides in plasma to form antibody-peptide complexes, and separately contacting the antibody-peptide complexes with a detection antibody to bind the detection antibody to the antibody-peptide complexes. The amount of p217+tau is determined by detecting the detection antibody. The amount of p217+tau detected is used to determine whether the subject has tauopathy or is at risk of developing tauopathy, or whether the subject has amyloidogenic disease or is at risk of developing amyloidogenic disease when the amount of p217+tau peptides is above a predetermined threshold value. The method has improved sensitivity such that the predetermined threshold value is above a Lower Limit of Quantification and/or Lower Limit of Detection of the assay.
    Type: Application
    Filed: July 14, 2021
    Publication date: January 20, 2022
    Applicant: Janssen Pharmaceutica NV
    Inventors: Hartmuth Christian KOLB, Gallen TRIANA-BALTZER, Ziad Serhal SAAD
  • Patent number: 10976325
    Abstract: Methods of measuring the amount of singly- or multiply-phosphorylated p217+ tau protein in a sample are provided. Methods of detecting or diagnosing tauopathies, methods of determining the effectiveness of a treatment of a tauopathy, and methods of determining whether a subject is suitable for anti-p217+ tau antibody therapy are also provided. Also described are antibodies for use in the methods and kits comprising the antibodies.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: April 13, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Hartmuth Christian Kolb, Gallen Triana-Baltzer, John Randall Slemmon
  • Publication number: 20200408781
    Abstract: Methods of measuring the amount of singly- or multiply-phosphorylated p217+ tau protein in a sample are provided. Methods of detecting or diagnosing tauopathies, methods of determining the effectiveness of a treatment of a tauopathy, and methods of determining whether a subject is suitable for anti-p217+ tau antibody therapy are also provided. Also described are antibodies for use in the methods and kits comprising the antibodies.
    Type: Application
    Filed: March 4, 2019
    Publication date: December 31, 2020
    Inventors: Hartmuth Christian Kolb, Gallen Triana-Baltzer, John Randall Slemmon
  • Publication number: 20200182888
    Abstract: Methods of measuring the amount of singly- or multiply-phosphorylated p217+ tau protein in a sample are provided. Methods of detecting or diagnosing tauopathies, methods of determining the effectiveness of a treatment of a tauopathy, and methods of determining whether a subject is suitable for anti-p217+ tau antibody therapy are also provided. Also described are antibodies for use in the methods and kits comprising the antibodies.
    Type: Application
    Filed: January 24, 2020
    Publication date: June 11, 2020
    Inventors: Hartmuth Christian Kolb, Gallen Triana-Baltzer, John Randall Slemmon
  • Patent number: 10591492
    Abstract: Methods of measuring the amount of singly- or multiply-phosphorylated p217+ tau protein in a sample are provided. Methods of detecting or diagnosing tauopathies, methods of determining the effectiveness of a treatment of a tauopathy, and methods of determining whether a subject is suitable for anti-p217+ tau antibody therapy are also provided. Also described are antibodies for use in the methods and kits comprising the antibodies.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: March 17, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Hartmuth Christian Kolb, Gallen Triana-Baltzer, John Randall Slemmon
  • Publication number: 20190271710
    Abstract: Methods of measuring the amount of singly- or multiply-phosphorylated p217+ tau protein in a sample are provided. Methods of detecting or diagnosing tauopathies, methods of determining the effectiveness of a treatment of a tauopathy, and methods of determining whether a subject is suitable for anti-p217+ tau antibody therapy are also provided. Also described are antibodies for use in the methods and kits comprising the antibodies.
    Type: Application
    Filed: March 4, 2019
    Publication date: September 5, 2019
    Inventors: Hartmuth Christian Kolb, Gallen Triana-Baltzer, John Randall Slemmon